MeSH term | MeSH ID | Detail |
---|---|---|
Brain Infarction | D020520 | 17 associated lipids |
Stroke | D020521 | 32 associated lipids |
Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yi T et al. | Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies. | 2017 | Drug Deliv | pmid:28165806 |
Kang H et al. | Puerarin inhibits M2 polarization and metastasis of tumor-associated macrophages from NSCLC xenograft model via inactivating MEK/ERK 1/2 pathway. | 2017 | Int. J. Oncol. | pmid:28101568 |
Li X et al. | Puerarin protects against endothelial dysfunction and end-organ damage in Ang II-induced hypertension. | 2017 | Clin. Exp. Hypertens. | pmid:28060542 |
Ge B et al. | Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin. | 2017 | Biopharm Drug Dispos | pmid:27925234 |
Li L et al. | Puerarin suppression of Aβ-induced primary cortical neuron death is largely dependent on ERβ. | 2017 | Brain Res. | pmid:27923632 |
Türer ÇC et al. | The Local Effect of Puerarin on Critical-Sized Calvarial Defects. | 2017 | J Craniofac Surg | pmid:27922959 |
Wei S et al. | Effect of puerarin on transcriptome of astrocyte during oxygen-glucose deprivation/reoxygenation injury. | 2017 | Mol. Cell. Biochem. | pmid:27844252 |
Cheng YF et al. | GPR30 Activation Contributes to the Puerarin-Mediated Neuroprotection in MPP-Induced SH-SY5Y Cell Death. | 2017 | J. Mol. Neurosci. | pmid:27796870 |
Cong X et al. | Puerarin ameliorates heat stress-induced oxidative damage and apoptosis in bovine Sertoli cells by suppressing ROS production and upregulating Hsp72 expression. | 2017 | Theriogenology | pmid:27771118 |
Zhao J et al. | Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI). | 2017 | Mol. Neurobiol. | pmid:27013468 |