MeSH term | MeSH ID | Detail |
---|---|---|
Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Dyspepsia | D004415 | 5 associated lipids |
Urinary Incontinence | D014549 | 4 associated lipids |
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wei S et al. | Effect of puerarin on transcriptome of astrocyte during oxygen-glucose deprivation/reoxygenation injury. | 2017 | Mol. Cell. Biochem. | pmid:27844252 |
Cheng YF et al. | GPR30 Activation Contributes to the Puerarin-Mediated Neuroprotection in MPP-Induced SH-SY5Y Cell Death. | 2017 | J. Mol. Neurosci. | pmid:27796870 |
Cong X et al. | Puerarin ameliorates heat stress-induced oxidative damage and apoptosis in bovine Sertoli cells by suppressing ROS production and upregulating Hsp72 expression. | 2017 | Theriogenology | pmid:27771118 |
Song X et al. | Restoration of autophagy by puerarin in lead-exposed primary rat proximal tubular cells via regulating AMPK-mTOR signaling. | 2017 | J. Biochem. Mol. Toxicol. | pmid:27762461 |
Sun H et al. | Simultaneous determination of epalrestat and puerarin in rat plasma by UHPLC-MS/MS: Application to their pharmacokinetic interaction study. | 2017 | Biomed. Chromatogr. | pmid:27650591 |
Li W et al. | Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx. | 2017 | Int. J. Mol. Med. | pmid:29039532 |
Yao Y et al. | Puerarin inhibits β‑amyloid peptide 1‑42‑induced tau hyperphosphorylation via the Wnt/β‑catenin signaling pathway. | 2017 | Mol Med Rep | pmid:28990074 |
Tu YM et al. | A high concentration of fatty acids induces TNF-α as well as NO release mediated by the P2X4 receptor, and the protective effects of puerarin in RAW264.7 cells. | 2017 | Food Funct | pmid:28937704 |
Zhang L et al. | Puerarin transport across rat nasal epithelial cells and the influence of compatibility with peoniflorin and menthol. | 2017 | Drug Des Devel Ther | pmid:28919709 |
Jing S et al. | A novel electrochemical sensor based on WO nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin. | 2017 | Talanta | pmid:28738611 |