MeSH term | MeSH ID | Detail |
---|---|---|
Neurotoxicity Syndromes | D020258 | 34 associated lipids |
Dyspepsia | D004415 | 5 associated lipids |
Urinary Incontinence | D014549 | 4 associated lipids |
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Li SM et al. | [Effect of puerarin on plasma endothelin, renin activity and angiotensin II in patients with acute myocardial infarction]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9863126 |
Wang L et al. | [Protective effect of puerarin on acute cerebral ischemia in rats]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11243176 |
Jin XL et al. | [Determination of puerarin in plasma by high performance liquid chromatography]. | 1997 | Yao Xue Xue Bao | pmid:11596224 |
Lin RC et al. | Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8800381 |
Shen XL et al. | Inhibition of [3H] flunitrazepam binding to rat brain membranes in vitro by puerarin and daidzein. | 1996 | Yao Xue Xue Bao | pmid:8762462 |
Overstreet DH et al. | Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8730211 |
Yue HW and Hu XQ | [Pharmacologic value of radix Puerariae and puerarine on cardiovascular system]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387770 |
Tan S et al. | [Determination of puerarin in gegen ginlian tablets by RP-HPLC]. | 1996 | Zhongguo Zhong Yao Za Zhi | pmid:9812678 |
Ji HL and Wang TY | Puerarin inhibits tetrodotoxin-resistant sodium current in rat dorsal root ganglion neurons. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9772657 |
Yasuda T et al. | Urinary and biliary metabolites of puerarin in rats. | 1995 | Biol. Pharm. Bull. | pmid:7742802 |