| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhu X et al. | The effect of puerarin against IL-1β-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). | 2014 | Mol. Vis. | pmid:25593509 |
| Hou JY et al. | Mucoadhesive microparticles for gastroretentive delivery: preparation, biodistribution and targeting evaluation. | 2014 | Mar Drugs | pmid:25470180 |
| Tiyasatkulkovit W et al. | Pueraria mirifica extract and puerarin enhance proliferation and expression of alkaline phosphatase and type I collagen in primary baboon osteoblasts. | 2014 | Phytomedicine | pmid:25442257 |
| Liu M et al. | Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord. | 2014 | Mediators Inflamm. | pmid:25089076 |
| Wang L et al. | Puerarin facilitates T-tubule development of murine embryonic stem cell-derived cardiomyocytes. | 2014 | Cell. Physiol. Biochem. | pmid:25059232 |
| Qu Q et al. | Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro. | 2014 | Acta Pharmacol. Sin. | pmid:24786236 |
| Shao J et al. | Spectroscopic and molecular docking studies of the in vitro interaction between puerarin and cytochrome P450. | 2014 | Molecules | pmid:24743933 |
| Liu Y et al. | Amelioration of stroke-induced neurological deficiency by lyophilized powder of catapol and puerarin. | 2014 | Int. J. Biol. Sci. | pmid:24719562 |
| Ma JQ et al. | Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24698568 |
| Chen G et al. | Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways. | 2014 | Acta Pharmacol. Sin. | pmid:24608673 |
| Li B et al. | Puerarin enhances bone mass by promoting osteoblastogenesis and slightly lowering bone marrow adiposity in ovariectomized rats. | 2014 | Biol. Pharm. Bull. | pmid:25590084 |
| Jung HR et al. | Simultaneous determination of puerarin and its active metabolite in human plasma by UPLC-MS/MS: application to a pharmacokinetic study. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25264914 |
| Zhang X et al. | Puerarin protects dopaminergic neurons in Parkinson's disease models. | 2014 | Neuroscience | pmid:25218963 |
| Fu R et al. | Digital gene expression analysis of the pathogenesis and therapeutic mechanisms of ligustrazine and puerarin in rat atherosclerosis. | 2014 | Gene | pmid:25218235 |
| Kim MH et al. | Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease. | 2014 | Planta Med. | pmid:25210998 |
| Wei SY et al. | Progress on the pharmacological research of puerarin: a review. | 2014 | Chin J Nat Med | pmid:24969520 |
| Park WS et al. | Anti-graying effect of the extract of Pueraria thunbergiana via upregulation of cAMP/MITF-M signaling pathway. | 2014 | J. Dermatol. Sci. | pmid:24924521 |
| Yu P et al. | Determination of puerarin in rat plasma using PEGylated magnetic carbon nanotubes by high performance liquid chromatography. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24768919 |
| Kim SB et al. | In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism. | 2014 | Planta Med. | pmid:24710899 |
| Lu XL et al. | Protective effects of puerarin against Aß40-induced vascular dysfunction in zebrafish and human endothelial cells. | 2014 | Eur. J. Pharmacol. | pmid:24690262 |
| Liu S et al. | Puerarin alleviates aggravated sympathoexcitatory response induced by myocardial ischemia via regulating P2X3 receptor in rat superior cervical ganglia. | 2014 | Neurochem. Int. | pmid:24657446 |
| Yan Y et al. | Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry. | 2014 | J Pharm Biomed Anal | pmid:24637051 |
| Wang S et al. | Efficient glycosylation of puerarin by an organic solvent-tolerant strain of Lysinibacillus fusiformis. | 2014 | Enzyme Microb. Technol. | pmid:24629266 |
| Li H et al. | Biopharmaceutics classification of puerarin and comparison of perfusion approaches in rats. | 2014 | Int J Pharm | pmid:24607203 |
| She S et al. | Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. | 2014 | Food Funct | pmid:24595557 |
| Liu G et al. | Puerarin protects against lead-induced cytotoxicity in cultured primary rat proximal tubular cells. | 2014 | Hum Exp Toxicol | pmid:24505050 |
| Tang L et al. | The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. | 2014 | Cell Biochem. Funct. | pmid:24496955 |
| Tang F et al. | Puerarin protects against Staphylococcus aureus-induced injury of human alveolar epithelial A549 cells via downregulating alpha-hemolysin secretion. | 2014 | Microb. Drug Resist. | pmid:24372183 |
| Zhou Y et al. | Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:24345484 |
| Wang N et al. | Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. | 2014 | Neuropharmacology | pmid:24333675 |
| Liu Q et al. | MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate. | 2014 | Pharm. Res. | pmid:24242937 |
| Liu Y et al. | Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor κB pathways. | 2014 | Chin J Integr Med | pmid:24122632 |
| Chen YG et al. | Metabolic differentiations of Pueraria lobata and Pueraria thomsonii using ¹H NMR spectroscopy and multivariate statistical analysis. | 2014 | J Pharm Biomed Anal | pmid:23746990 |
| Zhu G et al. | Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. | 2014 | Phytother Res | pmid:23512787 |
| Wang JW et al. | Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury. | 2014 | J. Surg. Res. | pmid:24079811 |
| Yuan Y et al. | Puerarin attenuates pressure overload-induced cardiac hypertrophy. | 2014 | J Cardiol | pmid:23906530 |
| Li Z et al. | Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. | 2014 | J. Mol. Endocrinol. | pmid:24827001 |
| Guo YJ et al. | In vivo inhibitory effects of puerarin on selected rat cytochrome P450 isoenzymes. | 2014 | Pharmazie | pmid:24855829 |
| Wu J et al. | Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials. | 2014 | J Tradit Chin Med | pmid:25185357 |
| Liu S et al. | Puerarin blocks the signaling transmission mediated by P2X3 in SG and DRG to relieve myocardial ischemic damage. | 2014 | Brain Res. Bull. | pmid:24447636 |
| Xu J et al. | A new flavonoid glycoside from the rhizomes and roots of Smilax scobinicaulis. | 2014 | Nat. Prod. Res. | pmid:24483603 |
| Mahdy HM et al. | Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: possible neuromodulation and antioxidant mechanisms. | 2014 | Neurochem. Res. | pmid:24346712 |
| Zhou YX et al. | Puerarin: a review of pharmacological effects. | 2014 | Phytother Res | pmid:24339367 |
| Zhong Y et al. | Puerarin attenuated early diabetic kidney injury through down-regulation of matrix metalloproteinase 9 in streptozotocin-induced diabetic rats. | 2014 | PLoS ONE | pmid:24454919 |
| Bao MH et al. | Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24708212 |
| Wang Y et al. | Simultaneous determination of four components in Baige capsule by HPLC: application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats. | 2014 | Biomed. Chromatogr. | pmid:24122939 |
| Gu L et al. | Polyamidomine dendrimers: an excellent drug carrier for improving the solubility and bioavailability of puerarin. | 2013 Sep-Oct | Pharm Dev Technol | pmid:22303809 |
| Xie J et al. | Improvement in solubility and bioavailability of puerarin by mechanochemical preparation. | 2013 | Drug Dev Ind Pharm | pmid:22591175 |
| Zhang E et al. | [Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23596875 |
| Tian F et al. | The neuroprotective mechanism of puerarin treatment of acute spinal cord injury in rats. | 2013 | Neurosci. Lett. | pmid:23570727 |