| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Fever | D005334 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Singh AK et al. | Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. | 2007 | J Med Food | pmid:17887948 |
| Benlhabib E et al. | Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations. | 2002 | J Med Food | pmid:12495583 |
| He Y et al. | Binding of puerarin to human serum albumin: a spectroscopic analysis and molecular docking. | 2008 | J Fluoresc | pmid:18058205 |
| Gao Y et al. | An isoflavonoid-enriched extract from Pueraria lobata (kudzu) root protects human umbilical vein endothelial cells against oxidative stress induced apoptosis. | 2016 | J Ethnopharmacol | pmid:27717903 |
| Wang D et al. | Evaluation of kudzu root extract-induced hepatotoxicity. | 2015 | J Ethnopharmacol | pmid:26545459 |
| Zhou J et al. | Puerarin attenuates glutamate-induced neurofilament axonal transport impairment. | 2010 | J Ethnopharmacol | pmid:20727960 |
| Haque Bhuiyan MM et al. | The neuritogenic and synaptogenic effects of the ethanolic extract of radix Puerariae in cultured rat hippocampal neurons. | 2015 | J Ethnopharmacol | pmid:26196403 |
| Tian F et al. | The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats. | 2011 | J Ethnopharmacol | pmid:21296138 |
| Zhang NB et al. | Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat. | 2011 | J Ethnopharmacol | pmid:22027447 |
| Yao XJ et al. | Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages. | 2012 | J Ethnopharmacol | pmid:22401764 |
| Bebrevska L et al. | In vivo antioxidative activity of a quantified Pueraria lobata root extract. | 2010 | J Ethnopharmacol | pmid:19799984 |
| Liang XL et al. | Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. | 2012 | J Ethnopharmacol | pmid:23085309 |
| Ho FM et al. | Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. | 2012 | J Ethnopharmacol | pmid:22543166 |
| Song JX et al. | Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? | 2012 | J Ethnopharmacol | pmid:22212501 |
| Deng Y et al. | Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery. | 2012 | J Ethnopharmacol | pmid:22120017 |
| Bhuiyan MMH et al. | Radix Puerariae modulates glutamatergic synaptic architecture and potentiates functional synaptic plasticity in primary hippocampal neurons. | 2017 | J Ethnopharmacol | pmid:28734961 |
| Wong KH et al. | Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. | 2011 | J Ethnopharmacol | pmid:21315814 |
| Jiang RW et al. | A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. | 2005 | J Ethnopharmacol | pmid:15588661 |
| Xu X and Zheng X | Potential involvement of calcium and nitric oxide in protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons. | 2007 | J Ethnopharmacol | pmid:17698307 |
| Li L and Zhang CR | Production of puerarin and isoflavones in cell suspension cultures of Pueraria lobata (Willd.): effects of medium supplementation with casein hydrolysate and coconut milk. | 2006 | J Environ Biol | pmid:16850870 |
| Severino P et al. | Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | 2012 | J Drug Deliv | pmid:22175030 |
| Li W et al. | Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats. | 2016 | J Diabetes Res | pmid:26881260 |
| Türer ÇC et al. | The Local Effect of Puerarin on Critical-Sized Calvarial Defects. | 2017 | J Craniofac Surg | pmid:27922959 |
| Zeng X et al. | Enhanced adsorption of puerarin onto a novel hydrophilic and polar modified post-crosslinked resin from aqueous solution. | 2012 | J Colloid Interface Sci | pmid:22878002 |
| Yu Z et al. | Determination of safflor yellow A, puerarin, ferulic acid, ginsenoside Rg1, and Rb1 in the Traditional Chinese Medicinal preparation Naodesheng injection by high-performance liquid chromatography. | 2006 May-Jun | J Chromatogr Sci | pmid:16774713 |
| He X et al. | Purification of the isoflavonoid puerarin by adsorption chromatography on cross-linked 12% agarose. | 2004 | J Chromatogr A | pmid:15584227 |
| He X et al. | Separation and purification of puerarin using beta-cyclodextrin-coupled agarose gel media. | 2004 | J Chromatogr A | pmid:14753773 |
| Lau CC et al. | Rapid analysis of Radix puerariae by near-infrared spectroscopy. | 2009 | J Chromatogr A | pmid:19185872 |
| Chen SB et al. | High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix Puerariae Lobate and Radix Puerariae Thomsonii. | 2006 | J Chromatogr A | pmid:16714027 |
| Delmonte P et al. | Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis. | 2006 | J Chromatogr A | pmid:16413562 |
| Wang CY et al. | Analysis of Puerariae radix and its medicinal preparations by capillary electrophoresis. | 1998 | J Chromatogr A | pmid:9588018 |
| Chen G et al. | Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection. | 2001 | J Chromatogr A | pmid:11510548 |
| Yuan Y et al. | Puerarin attenuates pressure overload-induced cardiac hypertrophy. | 2014 | J Cardiol | pmid:23906530 |
| Yang F et al. | Osteoblast response to puerarin-loaded porous titanium surfaces: an in vitro study. | 2012 | J Biomed Mater Res A | pmid:22374837 |
| Xu J et al. | PVA hydrogels containing beta-cyclodextrin for enhanced loading and sustained release of ocular therapeutics. | 2010 | J Biomater Sci Polym Ed | pmid:20507706 |
| Xu J et al. | Preparation and evaluation of a contact lens vehicle for puerarin delivery. | 2010 | J Biomater Sci Polym Ed | pmid:20178685 |
| Zhao R et al. | NMR studies on puerarin and its interaction with beta-cyclodextrin. | 2011 | J Biol Phys | pmid:22942483 |
| Feng ZQ et al. | The synthesis of puerarin derivatives and their protective effect on the myocardial ischemia and reperfusion injury. | 2010 | J Asian Nat Prod Res | pmid:20924897 |
| Wang PP et al. | Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways. | 2012 | J Asian Nat Prod Res | pmid:22917468 |
| Zhang SY et al. | The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction. | 2008 Mar-Apr | J Asian Nat Prod Res | pmid:18348063 |
| Penetar DM et al. | Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers. | 2006 Jul-Aug | J Altern Complement Med | pmid:16884345 |
| Keyler DE et al. | Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028. | 2002 | J Altern Complement Med | pmid:12006125 |
| Kang H et al. | Puerarin inhibits M2 polarization and metastasis of tumor-associated macrophages from NSCLC xenograft model via inactivating MEK/ERK 1/2 pathway. | 2017 | Int. J. Oncol. | pmid:28101568 |
| Zheng GM et al. | Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation. | 2012 | Int. J. Oncol. | pmid:22246431 |
| Zhang Y et al. | Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs. | 2013 | Int. J. Neurosci. | pmid:23668913 |
| Zhou Y et al. | Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:24345484 |
| Yu D et al. | Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways. | 2015 | Int. J. Mol. Med. | pmid:26101183 |
| Li W et al. | Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx. | 2017 | Int. J. Mol. Med. | pmid:29039532 |
| Kang OH et al. | Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. | 2015 | Int. J. Mol. Med. | pmid:25605057 |
| Chen F et al. | Puerarin-induced immune hemolytic anemia. | 2013 | Int. J. Hematol. | pmid:23661032 |