| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Fever | D005334 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim J et al. | Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22609359 |
| Jin SE et al. | Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots. | 2012 | Arch. Pharm. Res. | pmid:22644850 |
| Luo CF et al. | UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes. | 2012 | Arch. Toxicol. | pmid:22648071 |
| Wang R et al. | [Protective effects of puerarin on 60Co-gamma-induced acute injury of sertoli cells of testis in mice]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22686089 |
| Yu N et al. | The effects of sperminated pullulans on cornea permeability to puerarin and the toxicity. | 2012 | J Ocul Pharmacol Ther | pmid:22690870 |
| Han J et al. | [Study on 3'-methoxy puerarin to dynamic changes of amino acids in rat brain ischemia-reperfusion]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792810 |
| Huang MQ et al. | [Puerarin inhibits DNA damage of HaCaT cells induced by UVB via ceramide pathway]. | 2012 | Yao Xue Xue Bao | pmid:22812004 |
| Ko JA et al. | Enzymatic synthesis of puerarin glucosides using Leuconostoc dextransucrase. | 2012 | J. Microbiol. Biotechnol. | pmid:22814496 |
| Deng L et al. | [Effect of catalpol and puerarin freeze-dried powder on coagulability, hemorheology and no in rats with Qi-deficiency and blood-stasis syndrome]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860464 |
| Liang X et al. | [Intestinal absorption effect of Angelica dahurica extract on puerarin of puerariae Lobatae Radix]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860465 |
| Zeng X et al. | Enhanced adsorption of puerarin onto a novel hydrophilic and polar modified post-crosslinked resin from aqueous solution. | 2012 | J Colloid Interface Sci | pmid:22878002 |
| Michihara S et al. | Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway. | 2012 | J. Nutr. Sci. Vitaminol. | pmid:22878391 |
| Luo ZK et al. | [A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection]. | 2012 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:22883272 |
| Wang PP et al. | Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways. | 2012 | J Asian Nat Prod Res | pmid:22917468 |
| Saha P et al. | Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage. | 2012 | Reproduction | pmid:22919047 |
| Zhao R et al. | NMR studies on puerarin and its interaction with beta-cyclodextrin. | 2011 | J Biol Phys | pmid:22942483 |
| Tiyasatkulkovit W et al. | Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica. | 2012 | Phytomedicine | pmid:22951392 |
| Wang Y et al. | Formulation and pharmacokinetics evaluation of puerarin nanocrystals for intravenous delivery. | 2012 | J Nanosci Nanotechnol | pmid:22962724 |
| Fan JP et al. | Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology. | 2012 | Food Chem | pmid:22980805 |
| Wang Q et al. | [Distribution of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22994007 |
| Cheng W et al. | Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ß-estradiol-BSA. | 2012 | PLoS ONE | pmid:23029074 |
| Zhang J et al. | Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors. | 2013 | Burns | pmid:23044342 |
| Sheu SY et al. | Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice. | 2012 | Chin. Med. J. | pmid:23075718 |
| Liang XL et al. | Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. | 2012 | J Ethnopharmacol | pmid:23085309 |
| Zou Y et al. | Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway. | 2013 | Free Radic. Res. | pmid:23088308 |
| Wang Y et al. | In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. | 2013 | Int J Pharm | pmid:23089583 |
| Prasain JK et al. | The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. | 2012 | Phytomedicine | pmid:23123226 |
| Yin R et al. | UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. | 2013 | J Pharm Biomed Anal | pmid:23146236 |
| Li R et al. | Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23146695 |
| Chen F et al. | Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. | 2012 | Asian Pac J Trop Med | pmid:23146804 |
| Han JQ et al. | [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:23173255 |
| Tao HQ et al. | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23192284 |
| Liu B et al. | Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. | 2012 | J. Agric. Food Chem. | pmid:23215052 |
| Wang X et al. | Identification and assay of 3'-O-methyltaxifolin by UPLC-MS in rat plasma. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23217303 |
| Xue C et al. | [Determination of five components in Pueraria labta decoction with reference extraction method]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23234135 |
| Sun XY et al. | [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology]. | 2012 | Zhong Yao Cai | pmid:23236837 |
| Wang Q et al. | Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23246846 |
| Deng Y et al. | [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23270242 |
| Peng JH et al. | Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23277536 |
| Hu JJ et al. | [Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23311164 |
| Jiang L et al. | Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23314488 |
| Wang L et al. | Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats. | 2013 | Hum Exp Toxicol | pmid:23315276 |
| Nakamura K et al. | Enzymatic cleavage of the C-glucosidic bond of puerarin by three proteins, Mn(2+), and oxidized form of nicotinamide adenine dinucleotide. | 2013 | Biol. Pharm. Bull. | pmid:23328408 |
| Liu XY et al. | [Stability of PEGylated puerarin under different storage conditions]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23373208 |
| Zhang BS et al. | [Cellular absorption of the active ingredients in different compatibilities of gegenqinlian decoction in human intestinal Caco-2 cells]. | 2012 | Zhong Yao Cai | pmid:23451503 |
| An R et al. | [Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ]. | 2012 | Yao Xue Xue Bao | pmid:23460978 |
| Luo CF et al. | Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles. | 2013 | Int J Nanomedicine | pmid:23486407 |
| Cao L et al. | Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration. | 2013 | Fitoterapia | pmid:23500385 |
| Guo C et al. | Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. | 2013 | Food Chem. Toxicol. | pmid:23500774 |
| Liu CM et al. | Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase. | 2013 | Environ. Toxicol. Pharmacol. | pmid:23501611 |