| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Fever | D005334 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhu G et al. | Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. | 2014 | Phytother Res | pmid:23512787 |
| Bai S et al. | Effects of felodipine combined with puerarin on ACE2-Ang (1-7)-Mas axis in renovascular hypertensive rat. | 2013 | Regul. Pept. | pmid:23523569 |
| Tian F et al. | The neuroprotective mechanism of puerarin treatment of acute spinal cord injury in rats. | 2013 | Neurosci. Lett. | pmid:23570727 |
| Zhang E et al. | [Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23596875 |
| Li N et al. | Determination of glibenclamide and puerarin in rat plasma by UPLC-MS/MS: application to their pharmacokinetic interaction study. | 2013 | Talanta | pmid:23597896 |
| Li R et al. | Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats. | 2013 | Brain Res. | pmid:23603411 |
| Wang Y et al. | Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation. | 2013 | Phytomedicine | pmid:23639192 |
| Chen F et al. | Puerarin-induced immune hemolytic anemia. | 2013 | Int. J. Hematol. | pmid:23661032 |
| Cao WL et al. | [Effect of puerarin on hemorheology and pulmonary pressure in rat pneumo-cardiac disease]. | 2013 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:23662397 |
| Huang ZG et al. | [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23668014 |
| Zhang Y et al. | Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs. | 2013 | Int. J. Neurosci. | pmid:23668913 |
| Chen X et al. | Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats. | 2013 | Phytomedicine | pmid:23669266 |
| Ji O et al. | [Effect of flavonoids of puerarin on the proliferation and apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line NB4-R1 cells]. | 2013 | Zhonghua Xue Ye Xue Za Zhi | pmid:23688762 |
| Chen YG et al. | Metabolic differentiations of Pueraria lobata and Pueraria thomsonii using ¹H NMR spectroscopy and multivariate statistical analysis. | 2014 | J Pharm Biomed Anal | pmid:23746990 |
| Li R et al. | Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway. | 2013 | Brain Res. | pmid:23747813 |
| Li R et al. | Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3β/NF-κB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats. | 2013 | Int. Immunopharmacol. | pmid:23751897 |
| Xia DZ et al. | Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. | 2013 | Food Chem. Toxicol. | pmid:23764356 |
| Liu X et al. | Pharmacokinetic comparisons of puerarin, daidzin and the glucuronide metabolite of puerarin after administration of total flavonoid from Gegen alone and total flavonoid from Gegen combined with total saponin from Sanqi in rats under different physiological states. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23774247 |
| Wong KH et al. | Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA). | 2013 | J Pharm Biomed Anal | pmid:23777642 |
| Cheng M et al. | Puerarin accelerates re-endothelialization in a carotid arterial injury model: impact on vasodilator concentration and vascular cell functions. | 2013 | J. Cardiovasc. Pharmacol. | pmid:23792702 |
| Xu L et al. | Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect. | 2013 | Phytomedicine | pmid:23856441 |
| Zhao LX et al. | The permeability of puerarin loaded poly(butylcyanoacrylate) nanoparticles coated with polysorbate 80 on the blood-brain barrier and its protective effect against cerebral ischemia/reperfusion injury. | 2013 | Biol. Pharm. Bull. | pmid:23902970 |
| Yuan Y et al. | Puerarin attenuates pressure overload-induced cardiac hypertrophy. | 2014 | J Cardiol | pmid:23906530 |
| Ji M et al. | Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α. | 2013 | J. Steroid Biochem. Mol. Biol. | pmid:23907019 |
| Wu K et al. | Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23927877 |
| Wu X et al. | Isolation, identification and pharmacokinetic analysis of fructosyl puerarins from enzymatic glycosylation. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23948238 |
| Zhou A et al. | Lymphatic transport of puerarin occurs after oral administration of different lipid-based formulations to unconscious lymph duct-cannulated rats. | 2014 | Pharm Dev Technol | pmid:23978005 |
| Wang JW et al. | Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury. | 2014 | J. Surg. Res. | pmid:24079811 |
| Cheng Y et al. | Effects of puerarin on cardiac differentiation and ventricular specialization of murine embryonic stem cells. | 2013 | Cell. Physiol. Biochem. | pmid:24080853 |
| Tu L et al. | Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat. | 2013 | Int J Pharm | pmid:24120729 |
| Liu Y et al. | Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor κB pathways. | 2014 | Chin J Integr Med | pmid:24122632 |
| Wang Y et al. | Simultaneous determination of four components in Baige capsule by HPLC: application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats. | 2014 | Biomed. Chromatogr. | pmid:24122939 |
| Cui YH et al. | [Adsorption and isolation of macroporous resin for three isoflavonoids from puerariae lobatae radix]. | 2013 | Zhong Yao Cai | pmid:24134015 |
| Singh AK et al. | Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. | 2013 | J Med Food | pmid:24138167 |
| Liu Q et al. | MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate. | 2014 | Pharm. Res. | pmid:24242937 |
| Tang TT et al. | Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach. | 2013 | Int J Nanomedicine | pmid:24277986 |
| Wang N et al. | Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. | 2014 | Neuropharmacology | pmid:24333675 |
| Zhou YX et al. | Puerarin: a review of pharmacological effects. | 2014 | Phytother Res | pmid:24339367 |
| Zhou Y et al. | Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:24345484 |
| Mahdy HM et al. | Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: possible neuromodulation and antioxidant mechanisms. | 2014 | Neurochem. Res. | pmid:24346712 |
| Liu AC et al. | LC-MS/MS method for the determination of a new puerarin derivative and its application in pharmacokinetic studies in rats. | 2013 | Chin J Nat Med | pmid:24359785 |
| Tang F et al. | Puerarin protects against Staphylococcus aureus-induced injury of human alveolar epithelial A549 cells via downregulating alpha-hemolysin secretion. | 2014 | Microb. Drug Resist. | pmid:24372183 |
| Liu S et al. | Puerarin blocks the signaling transmission mediated by P2X3 in SG and DRG to relieve myocardial ischemic damage. | 2014 | Brain Res. Bull. | pmid:24447636 |
| Zhong Y et al. | Puerarin attenuated early diabetic kidney injury through down-regulation of matrix metalloproteinase 9 in streptozotocin-induced diabetic rats. | 2014 | PLoS ONE | pmid:24454919 |
| Liao D et al. | N-trimethyl chitosan (TMC)-modified microemulsions for improved oral bioavailability of puerarin: preparation and evaluation. | 2015 | Drug Deliv | pmid:24467620 |
| Xu J et al. | A new flavonoid glycoside from the rhizomes and roots of Smilax scobinicaulis. | 2014 | Nat. Prod. Res. | pmid:24483603 |
| Tang L et al. | The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. | 2014 | Cell Biochem. Funct. | pmid:24496955 |
| Liu G et al. | Puerarin protects against lead-induced cytotoxicity in cultured primary rat proximal tubular cells. | 2014 | Hum Exp Toxicol | pmid:24505050 |
| Bao L et al. | The anti-atherosclerotic effects of puerarin on induced-atherosclerosis in rabbits. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:24510110 |
| Qu H et al. | Development of an enzyme-linked immunosorbent assay based on anti-puerarin monoclonal antibody and its applications. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24583873 |