| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang S et al. | Optimization of ionic liquids-based microwave-assisted hydrolysis of puerarin and daidzein derivatives from Radix Puerariae Lobatae extract. | 2018 | Food Chem | pmid:29606431 |
| Ma JQ et al. | Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway. | 2014 | Food Chem. Toxicol. | pmid:24975872 |
| Yu C et al. | Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. | 2008 | Food Chem. Toxicol. | pmid:18848966 |
| Liu CM et al. | Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats. | 2011 | Food Chem. Toxicol. | pmid:22001170 |
| Guo C et al. | Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. | 2013 | Food Chem. Toxicol. | pmid:23500774 |
| Li R et al. | Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23146695 |
| Xia DZ et al. | Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. | 2013 | Food Chem. Toxicol. | pmid:23764356 |
| Wu K et al. | Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23927877 |
| She S et al. | Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. | 2014 | Food Funct | pmid:24595557 |
| Tu YM et al. | A high concentration of fatty acids induces TNF-α as well as NO release mediated by the P2X4 receptor, and the protective effects of puerarin in RAW264.7 cells. | 2017 | Food Funct | pmid:28937704 |
| Barnes S et al. | The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. | 2011 | Food Funct | pmid:21779561 |
| Kim J et al. | Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22609359 |
| Zhu LH et al. | Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling. | 2010 | Free Radic. Biol. Med. | pmid:19854265 |
| Zou Y et al. | Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway. | 2013 | Free Radic. Res. | pmid:23088308 |
| Branco DM et al. | Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis. | 2010 | Front Aging Neurosci | pmid:20577640 |
| Chen YY et al. | Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation. | 2012 | Fundam Clin Pharmacol | pmid:21352351 |
| Li R et al. | Puerarin exerts the protective effect against chemical induced dysmetabolism in rats. | 2016 | Gene | pmid:27677221 |
| Xu X et al. | Puerarin, isolated from Pueraria lobata (Willd.), protects against diabetic nephropathy by attenuating oxidative stress. | 2016 | Gene | pmid:27317894 |
| Fu R et al. | Digital gene expression analysis of the pathogenesis and therapeutic mechanisms of ligustrazine and puerarin in rat atherosclerosis. | 2014 | Gene | pmid:25218235 |
| Jiang QD and Li XP | Effect of puerarin on the expression of NMU, NPY, and POMC genes in the hypothalamus. | 2016 | Genet. Mol. Res. | pmid:26985919 |
| Plontke S | Therapy of hearing disorders - conservative procedures. | 2005 | GMS Curr Top Otorhinolaryngol Head Neck Surg | pmid:22073049 |
| Chen B et al. | [The rapid analysis of functional components of P. Lobata by near infrared spectrum]. | 2002 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12914179 |
| Han MX et al. | [Identification of three-step IR spectra of radix Puerariae from different habitats]. | 2009 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:19798956 |
| Zhang GW et al. | [Studies on the interaction between puerarin and bovine serum albumin]. | 2007 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:18051529 |
| Zhang XP et al. | Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis. | 2011 | HBPD INT | pmid:22146628 |
| Liu H et al. | Puerarin and zinc additively prevent mandibular bone loss through inhibiting osteoclastogenesis in ovariectomized rats. | 2017 | Histol. Histopathol. | pmid:27966208 |
| Jung DY et al. | Induction of growth hormone release by Pueraria thunbergiana BENTH. | 2004 | Horm. Metab. Res. | pmid:15002057 |
| Liu G et al. | Puerarin protects against lead-induced cytotoxicity in cultured primary rat proximal tubular cells. | 2014 | Hum Exp Toxicol | pmid:24505050 |
| Wang L et al. | Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats. | 2013 | Hum Exp Toxicol | pmid:23315276 |
| Peng XY et al. | [Study on the differentiation and apoptosis of HL-60 cell line induced by Puerarin]. | 2001 | Hunan Yi Ke Da Xue Xue Bao | pmid:12536642 |
| Ning Y et al. | [Effects of purerarin on blood superoxide dismutase activities and plasma malondialdehyde levels in patients with angina pectoris]. | 1997 | Hunan Yi Ke Da Xue Xue Bao | pmid:9868043 |
| Duan S et al. | [Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure]. | 2000 | Hunan Yi Ke Da Xue Xue Bao | pmid:12212215 |
| Wang J et al. | Puerarin attenuates airway inflammation by regulation of eotaxin-3. | 2015 | Immunol. Lett. | pmid:25530546 |
| Semalty A et al. | Development and evaluation of pharmacosomes of aceclofenac. | 2010 | Indian J Pharm Sci | pmid:21694988 |
| Wu M et al. | Effects of delayed puerarin treatment in long-term neurological outcomes of focal ischemic stroke in rats. | 2014 Mar-Apr | Indian J Pharmacol | pmid:24741185 |
| Zhang J et al. | Puerarin attenuates cognitive dysfunction and oxidative stress in vascular dementia rats induced by chronic ischemia. | 2015 | Int J Clin Exp Pathol | pmid:26191159 |
| Gasser P et al. | Glycation induction and antiglycation activity of skin care ingredients on living human skin explants. | 2011 | Int J Cosmet Sci | pmid:21401648 |
| Wang K et al. | Neuroprotective Effect of Puerarin on Glutamate-Induced Cytotoxicity in Differentiated Y-79 Cells via Inhibition of ROS Generation and Ca(2+) Influx. | 2016 | Int J Mol Sci | pmid:27409614 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Hanhineva K et al. | Impact of dietary polyphenols on carbohydrate metabolism. | 2010 | Int J Mol Sci | pmid:20480025 |
| Chen CC et al. | Hazardous effects of curcumin on mouse embryonic development through a mitochondria-dependent apoptotic signaling pathway. | 2010 | Int J Mol Sci | pmid:21152277 |
| Li Q et al. | Neuroprotective properties of picroside II in a rat model of focal cerebral ischemia. | 2010 | Int J Mol Sci | pmid:21151457 |
| Slámová K et al. | "Sweet Flavonoids": Glycosidase-Catalyzed Modifications. | 2018 | Int J Mol Sci | pmid:30037103 |
| Lee IK et al. | Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. | 2010 | Int J Mol Sci | pmid:21614182 |
| Mukherjee B et al. | Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers. | 2008 | Int J Nanomedicine | pmid:19337417 |
| Rudra A et al. | Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats. | 2010 | Int J Nanomedicine | pmid:21042545 |
| Luo CF et al. | Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles. | 2013 | Int J Nanomedicine | pmid:23486407 |
| Wang J et al. | Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. | 2017 | Int J Nanomedicine | pmid:29158673 |
| Tang TT et al. | Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach. | 2013 | Int J Nanomedicine | pmid:24277986 |
| Kalani M and Yunus R | Application of supercritical antisolvent method in drug encapsulation: a review. | 2011 | Int J Nanomedicine | pmid:21796245 |