| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gang C et al. | Puerarin Suppresses Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting NADPH Oxidase Activation and Oxidative Stress-Triggered AP-1 Signaling Pathways. | 2015 | J Pharm Pharm Sci | pmid:26158288 |
| Yan F et al. | Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats. | 2012 | J Pharm Pharm Sci | pmid:22579001 |
| Yu A et al. | Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion. | 2011 | J Pharm Sci | pmid:20862776 |
| Liu R et al. | Gelucire44/14 as a novel absorption enhancer for drugs with different hydrophilicities: in vitro and in vivo improvement on transcorneal permeation. | 2011 | J Pharm Sci | pmid:21416467 |
| Li H et al. | Comparison of two approaches of intestinal absorption by puerarin. | J Pharmacol Toxicol Methods | pmid:24674709 | |
| Han RM et al. | Fast regeneration of carotenoids from radical cations by isoflavonoid dianions: importance of the carotenoid keto group for electron transfer. | 2010 | J Phys Chem A | pmid:19957978 |
| Zhang H et al. | Insight into the structural deformations of beta-cyclodextrin caused by alcohol cosolvents and guest molecules. | 2012 | J Phys Chem B | pmid:22376204 |
| Zhang H et al. | Investigation of the inclusions of puerarin and daidzin with beta-cyclodextrin by molecular dynamics simulation. | 2010 | J Phys Chem B | pmid:20297792 |
| Tian YX et al. | Radical dynamics of puerarin as revealed by laser flash photolysis and spin density analysis. | 2008 | J Phys Chem B | pmid:18232684 |
| Chen L et al. | Simultaneous analysis of nine active components in Gegen Qinlian preparations by high-performance liquid chromatography with diode array detection. | 2006 | J Sep Sci | pmid:17069251 |
| Lv Y et al. | Preparation of monomeric and polymeric β-cyclodextrin functionalized monoliths for rapid isolation and purification of puerarin from Radix puerariae. | 2011 | J Sep Sci | pmid:21766485 |
| Zhao X et al. | Simultaneous determination of six isoflavonoids in rat plasma after administration of total flavonoid from Gegen by ultra-HPLC-MS/MS. | 2012 | J Sep Sci | pmid:22589159 |
| Sun C et al. | On-line HPLC method for screening of antioxidants against superoxide anion radical from complex mixtures. | 2010 | J Sep Sci | pmid:20183820 |
| Tian H et al. | Liquid chromatography-mass spectrometric analysis of puerarin and its metabolite in human urine. | 2006 | J Sep Sci | pmid:17313111 |
| Chen J et al. | Puerarin affects bone biomarkers in the serum of rats with intrauterine growth restriction. | 2016 | J Tradit Chin Med | pmid:27400476 |
| Xu X et al. | Puerarin reduces apoptosis in rat hippocampal neurons culturea in high glucose medium by modulating the p38 mitogen activated protein kinase and c-Jun N-terminal kinase signaling pathways. | 2016 | J Tradit Chin Med | pmid:26946623 |
| Wu J et al. | Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials. | 2014 | J Tradit Chin Med | pmid:25185357 |
| Zhu H et al. | Effect of puerarin on matrix metalloproteinase-2 in human fetal scleral fibroblasts treated with low frequency electromagnetic fields. | 2013 | J Tradit Chin Med | pmid:24660593 |
| Zhao L et al. | Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms. | 2016 | J. Agric. Food Chem. | pmid:27609057 |
| Meezan E et al. | Contrasting effects of puerarin and daidzin on glucose homeostasis in mice. | 2005 | J. Agric. Food Chem. | pmid:16248582 |
| Prasain JK et al. | Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry. | 2004 | J. Agric. Food Chem. | pmid:15186086 |
| Reppert A et al. | Isolation of radiolabeled isoflavones from kudzu (Pueraria lobata) root cultures. | 2008 | J. Agric. Food Chem. | pmid:18690681 |
| Liu B et al. | Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. | 2012 | J. Agric. Food Chem. | pmid:23215052 |
| Cervellati R et al. | Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. | 2002 | J. Agric. Food Chem. | pmid:12475261 |
| Han RM et al. | Phenol acidity and ease of oxidation in isoflavonoid/β-carotene antioxidant synergism. | 2011 | J. Agric. Food Chem. | pmid:21863887 |
| Tanaka T et al. | Kudzu (Pueraria lobata) vine ethanol extracts improve ovariectomy-induced bone loss in female mice. | 2011 | J. Agric. Food Chem. | pmid:22053809 |
| Choi CW et al. | Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. | 2010 | J. Agric. Food Chem. | pmid:20734984 |
| Xiao J et al. | Glycosylation of dietary flavonoids decreases the affinities for plasma protein. | 2009 | J. Agric. Food Chem. | pmid:19722570 |
| Hirota K et al. | Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line. | 2010 | J. Agric. Food Chem. | pmid:20397699 |
| Han RM et al. | Puerarin and conjugate bases as radical scavengers and antioxidants: molecular mechanism and synergism with beta-carotene. | 2007 | J. Agric. Food Chem. | pmid:17300199 |
| Kirakosyan A et al. | Isoflavone levels in five soybean (Glycine max) genotypes are altered by phytochrome-mediated light treatments. | 2006 | J. Agric. Food Chem. | pmid:16390177 |
| Simons AL et al. | Human gut microbial degradation of flavonoids: structure-function relationships. | 2005 | J. Agric. Food Chem. | pmid:15884869 |
| Prasain JK et al. | Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. | 2003 | J. Agric. Food Chem. | pmid:12848487 |
| Hong XP et al. | Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. | 2016 | J. Alzheimers Dis. | pmid:26890737 |
| Song X et al. | Restoration of autophagy by puerarin in lead-exposed primary rat proximal tubular cells via regulating AMPK-mTOR signaling. | 2017 | J. Biochem. Mol. Toxicol. | pmid:27762461 |
| Zhu X et al. | Puerarin Protects Human Neuroblastoma SH-SY5Y Cells against Glutamate-Induced Oxidative Stress and Mitochondrial Dysfunction. | 2016 | J. Biochem. Mol. Toxicol. | pmid:26277993 |
| Chang Y et al. | Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats. | 2009 | J. Biomed. Sci. | pmid:19272172 |
| Qin H et al. | Puerarin Suppresses Na+-K+-ATPase-Mediated Systemic Inflammation and CD36 Expression, and Alleviates Cardiac Lipotoxicity In Vitro and In Vivo. | 2016 | J. Cardiovasc. Pharmacol. | pmid:27606935 |
| Cheng M et al. | Puerarin accelerates re-endothelialization in a carotid arterial injury model: impact on vasodilator concentration and vascular cell functions. | 2013 | J. Cardiovasc. Pharmacol. | pmid:23792702 |
| Liu X et al. | A HPLC-UV method for the determination of puerarin in rat plasma after intravenous administration of PEGylated puerarin conjugate. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21056017 |
| Luo CF et al. | Determination of puerarin in rat plasma by rapid resolution liquid chromatography tandem mass spectrometry in positive ionization mode. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21511546 |
| Guo HD et al. | Large scale purification of puerarin from Puerariae Lobatae Radix through resins adsorption and acid hydrolysis. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25553536 |
| Yu P et al. | Determination of puerarin in rat plasma using PEGylated magnetic carbon nanotubes by high performance liquid chromatography. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24768919 |
| Lv YQ et al. | One-step rapid determination and purification of puerarin from Radix puerariae by n-octylamine-modified poly(methacrylate-co-ethylene dimethacrylate) monolith. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18639505 |
| Luo CF et al. | Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: similar metabolic profiles in liver and intestine of rats. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20006564 |
| Wang Q et al. | Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23246846 |
| Wu X et al. | Isolation, identification and pharmacokinetic analysis of fructosyl puerarins from enzymatic glycosylation. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23948238 |
| Wen A et al. | A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of hydroxysafflor yellow A in human plasma: application to a pharmacokinetic study. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18964371 |
| Jiang L et al. | Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23314488 |
| Wang Q et al. | Quantification of puerarin in plasma by on-line solid-phase extraction column switching liquid chromatography-tandem mass spectrometry and its applications to a pharmacokinetic study. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18242154 |