| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu IM and Cheng JT | Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats. | 2011 | Evid Based Complement Alternat Med | pmid:19095661 |
| Xu HX et al. | [Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process]. | 2011 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:21418943 |
| Xing G et al. | Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. | 2011 | Brain Res. Bull. | pmid:21473901 |
| Hou SZ et al. | Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. | 2011 | Chem. Biol. Interact. | pmid:21453687 |
| Luo CF et al. | Determination of puerarin in rat plasma by rapid resolution liquid chromatography tandem mass spectrometry in positive ionization mode. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21511546 |
| Yu A et al. | Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion. | 2011 | J Pharm Sci | pmid:20862776 |
| Zhang H et al. | Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. | 2011 | Exp. Gerontol. | pmid:20933077 |
| Wang G et al. | Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells. | 2011 | Neurosci. Lett. | pmid:20934486 |
| Tian F et al. | The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats. | 2011 | J Ethnopharmacol | pmid:21296138 |
| He X et al. | A genomic approach to isoflavone biosynthesis in kudzu (Pueraria lobata). | 2011 | Planta | pmid:21221632 |
| Zhu YM et al. | [Effect and mechanism of puerarin on high glucose-induced hypo-responses in vascular contraction]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21560344 |
| Braune A and Blaut M | Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium. | 2011 | Environ. Microbiol. | pmid:20946528 |
| Wang D et al. | Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17β-estradiol. | 2011 | PLoS ONE | pmid:21949833 |
| Zhang NB et al. | Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat. | 2011 | J Ethnopharmacol | pmid:22027447 |
| Chen R et al. | [Simultaneous quantification of five impurities in puerarin and its injections by HPLC method with correction factor]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22032137 |
| Chen XX et al. | [Pharmacokinetics and bioavailability of Puerarin self-microemulsion in Beagle dogs]. | 2011 | Zhong Yao Cai | pmid:21954564 |
| Pan ZJ et al. | [Effects of puerarin on blood pressure, blood lipid and renal structure of cold-induced hypertensive mice]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22295519 |
| Zhang L et al. | Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin. | 2011 | Chin Med | pmid:22108408 |
| Cui SQ | [Effect of puerarin in myocardial protection in rats with acute and chronic alcoholism]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22200707 |
| Chen C et al. | [Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia]. | 2011 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22357486 |
| Zhang R et al. | [Effect of puerarin on the expression of NMDA receptor in the hippocampus CA1 region after focal cerebral ischemia in rats]. | 2011 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:21355301 |
| Zhang H et al. | Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). | 2011 | Mol. Cell. Biochem. | pmid:21327545 |
| Yao C et al. | [Ocular pharmacokinetics of puerarin in anesthetic rabbits by microdialysis]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097338 |
| Zhang X et al. | [Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097342 |
| Chen X et al. | [Study on pharmacokinetics of puerarin in rats following different methods of administration of Tongqiao Sanyu prescription]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22121800 |
| Hsiang SW et al. | Puerarin accelerates peripheral nerve regeneration. | 2011 | Am. J. Chin. Med. | pmid:22083991 |
| Hwang YP et al. | Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21884717 |
| Yao C et al. | Effects of poly(amidoamine) dendrimers on ocular absorption of puerarin using microdialysis. | 2011 | J Ocul Pharmacol Ther | pmid:21895496 |
| Hao LN et al. | Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial cells in response to stimulation by peroxynitrite and antagonism of puerarin. | 2011 | Chin. Med. J. | pmid:21933599 |
| Baranowska I et al. | UHPLC method for the simultaneous determination of β-blockers, isoflavones and their metabolites in human urine. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21345747 |
| Wong KH et al. | Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. | 2011 | J Ethnopharmacol | pmid:21315814 |
| Wang WY et al. | Determination of puerarin in rabbit aqueous humor by liquid chromatography tandem mass spectrometry using microdialysis sampling after topical administration of puerarin PAMAM dendrimer complex. | 2011 | J Pharm Biomed Anal | pmid:21831555 |
| Zhao R et al. | NMR studies on puerarin and its interaction with beta-cyclodextrin. | 2011 | J Biol Phys | pmid:22942483 |
| Lipovac M et al. | Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women. | 2011 | Obstet Gynecol Int | pmid:22135679 |
| Li X et al. | Puerarin alleviates burn-related procedural pain mediated by P2X(3) receptors. | 2011 | Purinergic Signal. | pmid:21833698 |
| Kalani M and Yunus R | Application of supercritical antisolvent method in drug encapsulation: a review. | 2011 | Int J Nanomedicine | pmid:21796245 |
| Pan SY et al. | New perspectives on chinese herbal medicine (zhong-yao) research and development. | 2011 | Evid Based Complement Alternat Med | pmid:21785622 |
| Kim J et al. | KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953387 |
| Baranowska I and Magiera S | Analysis of isoflavones and flavonoids in human urine by UHPLC. | 2011 | Anal Bioanal Chem | pmid:20936271 |
| Xie W and Du L | Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. | 2011 | Diabetes Obes Metab | pmid:21205111 |
| Qin P et al. | Characterization and selectivity studies of molecular imprinted membranes of Puerarin using scanning electron microscopy. | 2011 Jan-Feb | Scanning | pmid:21246571 |
| Chauhan NS et al. | Spectrofluorimetric estimation of puerarin in Pueraria tuberosa. | 2011 May-Jun | Acta Pol Pharm | pmid:21648202 |
| Zhao C et al. | Rapid simultaneous determination of major isoflavones of Pueraria lobata and discriminative analysis of its geographical origins by principal component analysis. | 2011 Nov-Dec | Phytochem Anal | pmid:21495105 |
| Yang R et al. | Determination of puerarin in biological samples and its application to a pharmacokinetic study by flow-injection chemiluminescence. | 2011 Sep-Oct | Luminescence | pmid:21547999 |
| Liu CM et al. | Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead. | 2012 | Exp. Toxicol. Pathol. | pmid:21146379 |
| Zhang H et al. | A model for the shuttle motions of puerarin and daidzin inside the cavity of β-cyclodextrin in aqueous acetic acid: insights from molecular dynamics simulations. | 2012 | J Mol Model | pmid:21523551 |
| Penetar DM et al. | The isoflavone puerarin reduces alcohol intake in heavy drinkers: a pilot study. | 2012 | Drug Alcohol Depend | pmid:22578529 |
| Kim J et al. | Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22609359 |
| Luo J et al. | Molecularly imprinted layer-coated monodisperse spherical silica microparticles toward affinity-enrichment of isoflavonoid glycosides from Radix puerariae. | 2012 | Analyst | pmid:22553769 |
| Sun L et al. | Involvement of abscisic acid in ozone-induced puerarin production of Pueraria thomsnii Benth. suspension cell cultures. | 2012 | Plant Cell Rep. | pmid:21947422 |
| Zhu G et al. | Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. | 2012 | Neurochem. Int. | pmid:22265823 |
| Zheng GM et al. | Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation. | 2012 | Int. J. Oncol. | pmid:22246431 |
| Lin F et al. | Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons. | 2012 | Arzneimittelforschung | pmid:22278629 |
| Tang XL et al. | Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarin and 17β-oestradiol in ovariectomized rats. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22333267 |
| Huang F et al. | Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner. | 2012 | Biochimie | pmid:22314193 |
| Coghlan ML et al. | Deep sequencing of plant and animal DNA contained within traditional Chinese medicines reveals legality issues and health safety concerns. | 2012 | PLoS Genet. | pmid:22511890 |
| Zeng A et al. | Simultaneous analysis and retention behavior of major isoflavonoids in Radix Puerariae lobatae and Radix Puerariae thomsonii by high performance liquid chromatography with cyclodextrins as a mobile phase modifier. | 2012 | Anal. Chim. Acta | pmid:22177078 |
| Huang MQ et al. | [Puerarin inhibits DNA damage of HaCaT cells induced by UVB via ceramide pathway]. | 2012 | Yao Xue Xue Bao | pmid:22812004 |
| Ko JA et al. | Enzymatic synthesis of puerarin glucosides using Leuconostoc dextransucrase. | 2012 | J. Microbiol. Biotechnol. | pmid:22814496 |
| Han J et al. | [Study on 3'-methoxy puerarin to dynamic changes of amino acids in rat brain ischemia-reperfusion]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792810 |
| Liang J et al. | Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats. | 2012 | Mol Med Rep | pmid:22470138 |
| Cho HJ et al. | Acute effect of high-dose isoflavones from Pueraria lobata (Willd.) Ohwi on lipid and bone metabolism in ovariectomized mice. | 2012 | Phytother Res | pmid:22422661 |
| Zhang MY et al. | In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. | 2012 | Chin J Integr Med | pmid:22457138 |
| Pang W et al. | Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils. | 2012 | Chin J Integr Med | pmid:22457139 |
| Zhao Y and Zhou Y | Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. | 2012 | Chin J Integr Med | pmid:22457141 |
| Chen C et al. | Puerarin induces mitochondria-dependent apoptosis in hypoxic human pulmonary arterial smooth muscle cells. | 2012 | PLoS ONE | pmid:22457823 |
| Hao LN et al. | Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. | 2012 | Sheng Li Xue Bao | pmid:22513471 |
| Yao XJ et al. | Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages. | 2012 | J Ethnopharmacol | pmid:22401764 |
| Yu N et al. | The effects of sperminated pullulans on cornea permeability to puerarin and the toxicity. | 2012 | J Ocul Pharmacol Ther | pmid:22690870 |
| Wang R et al. | [Protective effects of puerarin on 60Co-gamma-induced acute injury of sertoli cells of testis in mice]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22686089 |
| Luo CF et al. | UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes. | 2012 | Arch. Toxicol. | pmid:22648071 |
| Yang F et al. | Osteoblast response to puerarin-loaded porous titanium surfaces: an in vitro study. | 2012 | J Biomed Mater Res A | pmid:22374837 |
| Zhang H et al. | Insight into the structural deformations of beta-cyclodextrin caused by alcohol cosolvents and guest molecules. | 2012 | J Phys Chem B | pmid:22376204 |
| Hou Q et al. | [Puerarin combined with avandia for diabetic nephropathy]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22349389 |
| Liu L et al. | Determination of puerarin in pharmaceutical and biological samples by capillary zone electrophoresis with UV detection. | 2012 | Talanta | pmid:22365684 |
| Zhang Y et al. | Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery. | 2012 | Int J Pharm | pmid:22366381 |
| Deng L et al. | [Effect of catalpol and puerarin freeze-dried powder on coagulability, hemorheology and no in rats with Qi-deficiency and blood-stasis syndrome]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860464 |
| Liu B et al. | Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. | 2012 | J. Agric. Food Chem. | pmid:23215052 |
| Xue C et al. | [Determination of five components in Pueraria labta decoction with reference extraction method]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23234135 |
| Sun XY et al. | [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology]. | 2012 | Zhong Yao Cai | pmid:23236837 |
| Chen YY et al. | Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation. | 2012 | Fundam Clin Pharmacol | pmid:21352351 |
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| Xu C et al. | Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons. | 2012 | Brain Res. Bull. | pmid:22044944 |
| Cheng W et al. | Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ß-estradiol-BSA. | 2012 | PLoS ONE | pmid:23029074 |
| Zhao X et al. | Simultaneous determination of six isoflavonoids in rat plasma after administration of total flavonoid from Gegen by ultra-HPLC-MS/MS. | 2012 | J Sep Sci | pmid:22589159 |
| Sheu SY et al. | Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice. | 2012 | Chin. Med. J. | pmid:23075718 |
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| Li Y et al. | Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats. | 2012 | Biomed. Chromatogr. | pmid:22253022 |
| Song JX et al. | Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? | 2012 | J Ethnopharmacol | pmid:22212501 |
| Deng Y et al. | Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery. | 2012 | J Ethnopharmacol | pmid:22120017 |
| Yu L et al. | Biotransformation of puerarin into puerarin-6″-O-phosphate by Bacillus cereus. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:21882014 |
| Wang X et al. | Identification and assay of 3'-O-methyltaxifolin by UPLC-MS in rat plasma. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23217303 |
| Wen Y et al. | Simultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS. | 2012 | Biomed. Chromatogr. | pmid:21830226 |
| Luo J and Xu H | Outcome measures of chinese herbal medicine for coronary heart disease: an overview of systematic reviews. | 2012 | Evid Based Complement Alternat Med | pmid:22606207 |
| Yan F et al. | Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats. | 2012 | J Pharm Pharm Sci | pmid:22579001 |
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