| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu Q et al. | MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate. | 2014 | Pharm. Res. | pmid:24242937 |
| Li Y et al. | Comparative physicochemical characterization of phospholipids complex of puerarin formulated by conventional and supercritical methods. | 2008 | Pharm. Res. | pmid:17828444 |
| Ji L et al. | Puerarin inhibits the inflammatory response in atherosclerosis via modulation of the NF-κB pathway in a rabbit model. | 2016 | Pharmacol Rep | pmid:27505855 |
| Hu W et al. | Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. | 2011 | Pharmacol Rep | pmid:21857089 |
| Overstreet DH et al. | NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. | 2003 | Pharmacol. Biochem. Behav. | pmid:12895679 |
| Rezvani AH et al. | Plant derivatives in the treatment of alcohol dependency. | 2003 | Pharmacol. Biochem. Behav. | pmid:12895677 |
| Hu W et al. | Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway. | 2010 | Pharmacology | pmid:20016245 |
| Wang L et al. | Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-γ Coactivator-1 Signaling Pathway in Osteoarthritis Rats. | 2018 | Pharmacology | pmid:29961054 |
| Matkowski A et al. | Flavonoids of Pueraria lobata: chromatographic analysis of leaves and roots of cultivated plants. | 2003 | Pharmazie | pmid:14531473 |
| Hu Y et al. | Inhibitory effect of puerarin on vascular smooth muscle cells proliferation induced by oxidised low-density lipoprotein via suppressing ERK 1/2 phosphorylation and PCNA expression. | 2016 | Pharmazie | pmid:27004373 |
| Wu CJ et al. | Promoting effect of borneol on the permeability of puerarin eye drops and timolol maleate eye drops through the cornea in vitro. | 2006 | Pharmazie | pmid:17020156 |
| Liu XJ et al. | The effects of genistein and puerarin on the activation of nuclear factor-kappaB and the production of tumor necrosis factor-alpha in asthma patients. | 2010 | Pharmazie | pmid:20225658 |
| Guo YJ et al. | In vivo inhibitory effects of puerarin on selected rat cytochrome P450 isoenzymes. | 2014 | Pharmazie | pmid:24855829 |
| Chang Q et al. | Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza) by high-performance liquid chromatography. | Phytochem Anal | pmid:18438756 | |
| Zhao C et al. | Rapid simultaneous determination of major isoflavones of Pueraria lobata and discriminative analysis of its geographical origins by principal component analysis. | 2011 Nov-Dec | Phytochem Anal | pmid:21495105 |
| Wu Y et al. | Optimisation of ultrasound-assisted extraction of puerarin and total isoflavones from Puerariae Lobatae Radix (Pueraria lobata (Wild.) Ohwi) with response surface methodology. | 2012 Sep-Oct | Phytochem Anal | pmid:22259187 |
| Nguyen VD et al. | Identification of a naturally-occurring 8-[alpha-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]daidzein from cultivated kudzu root. | Phytochem Anal | pmid:19609885 | |
| Xu YC et al. | Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery. | 2007 | Phytochemistry | pmid:17395220 |
| Tiyasatkulkovit W et al. | Pueraria mirifica extract and puerarin enhance proliferation and expression of alkaline phosphatase and type I collagen in primary baboon osteoblasts. | 2014 | Phytomedicine | pmid:25442257 |
| Zou ZJ et al. | Intervention effects of puerarin on blood stasis in rats revealed by a (1)H NMR-based metabonomic approach. | 2015 | Phytomedicine | pmid:25837270 |
| Wang Y et al. | Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-κB ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells. | Phytomedicine | pmid:24854571 | |
| Prasain JK et al. | Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry. | 2009 | Phytomedicine | pmid:19027277 |
| Tiyasatkulkovit W et al. | Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica. | 2012 | Phytomedicine | pmid:22951392 |
| Xu L et al. | Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect. | 2013 | Phytomedicine | pmid:23856441 |
| Wang Y et al. | Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation. | 2013 | Phytomedicine | pmid:23639192 |
| Chen X et al. | Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats. | 2013 | Phytomedicine | pmid:23669266 |
| Prasain JK et al. | The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. | 2012 | Phytomedicine | pmid:23123226 |
| Cherdshewasart W and Sutjit W | Correlation of antioxidant activity and major isoflavonoid contents of the phytoestrogen-rich Pueraria mirifica and Pueraria lobata tubers. | 2008 | Phytomedicine | pmid:17890070 |
| Wu L et al. | Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats. | 2007 | Phytomedicine | pmid:17870452 |
| He H et al. | The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. | 2008 | Phytother Res | pmid:18389490 |
| Wu H et al. | Puerarin Exerts an Antiinflammatory Effect by Inhibiting NF-kB and MAPK Activation in Staphylococcus aureus-Induced Mastitis. | 2016 | Phytother Res | pmid:27335240 |
| Liang XL et al. | Mechanisms of improvement of intestinal transport of baicalin and puerarin by extracts of Radix Angelicae Dahuricae. | 2015 | Phytother Res | pmid:25312586 |
| Cho HJ et al. | Acute effect of high-dose isoflavones from Pueraria lobata (Willd.) Ohwi on lipid and bone metabolism in ovariectomized mice. | 2012 | Phytother Res | pmid:22422661 |
| Zeng X et al. | Puerarin inhibits TRPM3/miR-204 to promote MC3T3-E1 cells proliferation, differentiation and mineralization. | 2018 | Phytother Res | pmid:29368357 |
| Zhu G et al. | Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. | 2014 | Phytother Res | pmid:23512787 |
| Retraction. The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. | 2009 | Phytother Res | pmid:19391125 | |
| Retraction. Cardioprotective effects of the combined use of puerarin and danshensu on acute ischemic myocardial injury in rats. | 2009 | Phytother Res | pmid:19391124 | |
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| Wu L et al. | Cardioprotective effects of the combined use of puerarin and Danshensu on acute ischemic myocardial injury in rats. | 2007 | Phytother Res | pmid:17450507 |
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| Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
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| Kirakosyan A et al. | Regulation of isoflavone production in hydroponically grown Pueraria montana (kudzu) by cork pieces, XAD-4, and methyl jasmonate. | 2006 | Plant Cell Rep. | pmid:16841218 |
| Sun L et al. | Involvement of abscisic acid in ozone-induced puerarin production of Pueraria thomsnii Benth. suspension cell cultures. | 2012 | Plant Cell Rep. | pmid:21947422 |
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| He X et al. | A genomic approach to isoflavone biosynthesis in kudzu (Pueraria lobata). | 2011 | Planta | pmid:21221632 |
| Hsu HH et al. | Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. | 2002 | Planta Med. | pmid:12451490 |
| Chen WC et al. | Mediation of beta-endorphin by the isoflavone puerarin to lower plasma glucose in streptozotocin-induced diabetic rats. | 2004 | Planta Med. | pmid:14994187 |
| Wu L et al. | Protective Effects of Puerarin against Aβ 1-42-Induced Learning and Memory Impairments in Mice. | 2017 | Planta Med. | pmid:27420352 |
| Xu X et al. | The Neuroprotection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats. | 2005 | Planta Med. | pmid:16041641 |
| Xu X et al. | Effects of puerarin on learning-memory and amino acid transmitters of brain in ovariectomized mice. | 2004 | Planta Med. | pmid:15303253 |
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| Kim MH et al. | Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease. | 2014 | Planta Med. | pmid:25210998 |
| Kim SB et al. | In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism. | 2014 | Planta Med. | pmid:24710899 |
| Gu L et al. | Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis. | 2010 | Planta Med. | pmid:19918715 |
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