Liu CM et al. |
Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead. |
2012 |
Exp. Toxicol. Pathol. |
pmid:21146379
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Sun L et al. |
Involvement of abscisic acid in ozone-induced puerarin production of Pueraria thomsnii Benth. suspension cell cultures. |
2012 |
Plant Cell Rep. |
pmid:21947422
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Zhu G et al. |
Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. |
2012 |
Neurochem. Int. |
pmid:22265823
|
Zheng GM et al. |
Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation. |
2012 |
Int. J. Oncol. |
pmid:22246431
|
Lin F et al. |
Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons. |
2012 |
Arzneimittelforschung |
pmid:22278629
|
Tang XL et al. |
Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarin and 17β-oestradiol in ovariectomized rats. |
2012 |
Basic Clin. Pharmacol. Toxicol. |
pmid:22333267
|
Zhao Y and Zhou Y |
Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. |
2012 |
Chin J Integr Med |
pmid:22457141
|
Chen C et al. |
Puerarin induces mitochondria-dependent apoptosis in hypoxic human pulmonary arterial smooth muscle cells. |
2012 |
PLoS ONE |
pmid:22457823
|
Hao LN et al. |
Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. |
2012 |
Sheng Li Xue Bao |
pmid:22513471
|
Yao XJ et al. |
Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages. |
2012 |
J Ethnopharmacol |
pmid:22401764
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Yu N et al. |
The effects of sperminated pullulans on cornea permeability to puerarin and the toxicity. |
2012 |
J Ocul Pharmacol Ther |
pmid:22690870
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Wang R et al. |
[Protective effects of puerarin on 60Co-gamma-induced acute injury of sertoli cells of testis in mice]. |
2012 |
Zhongguo Zhong Xi Yi Jie He Za Zhi |
pmid:22686089
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Luo CF et al. |
UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes. |
2012 |
Arch. Toxicol. |
pmid:22648071
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Yang F et al. |
Osteoblast response to puerarin-loaded porous titanium surfaces: an in vitro study. |
2012 |
J Biomed Mater Res A |
pmid:22374837
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Zhang H et al. |
Insight into the structural deformations of beta-cyclodextrin caused by alcohol cosolvents and guest molecules. |
2012 |
J Phys Chem B |
pmid:22376204
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Hou Q et al. |
[Puerarin combined with avandia for diabetic nephropathy]. |
2012 |
Zhong Nan Da Xue Xue Bao Yi Xue Ban |
pmid:22349389
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Liu B et al. |
Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. |
2012 |
J. Agric. Food Chem. |
pmid:23215052
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Xue C et al. |
[Determination of five components in Pueraria labta decoction with reference extraction method]. |
2012 |
Zhongguo Zhong Yao Za Zhi |
pmid:23234135
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Sun XY et al. |
[Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology]. |
2012 |
Zhong Yao Cai |
pmid:23236837
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Yu L et al. |
Biotransformation of puerarin into puerarin-6″-O-phosphate by Bacillus cereus. |
2012 |
J. Ind. Microbiol. Biotechnol. |
pmid:21882014
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Wang X et al. |
Identification and assay of 3'-O-methyltaxifolin by UPLC-MS in rat plasma. |
2012 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:23217303
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Wen Y et al. |
Simultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS. |
2012 |
Biomed. Chromatogr. |
pmid:21830226
|
Luo J and Xu H |
Outcome measures of chinese herbal medicine for coronary heart disease: an overview of systematic reviews. |
2012 |
Evid Based Complement Alternat Med |
pmid:22606207
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Yan F et al. |
Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats. |
2012 |
J Pharm Pharm Sci |
pmid:22579001
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Wang J and Xiong X |
Current situation and perspectives of clinical study in integrative medicine in china. |
2012 |
Evid Based Complement Alternat Med |
pmid:22550539
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Wu Y et al. |
Optimisation of ultrasound-assisted extraction of puerarin and total isoflavones from Puerariae Lobatae Radix (Pueraria lobata (Wild.) Ohwi) with response surface methodology. |
2012 Sep-Oct |
Phytochem Anal |
pmid:22259187
|
Xie J et al. |
Improvement in solubility and bioavailability of puerarin by mechanochemical preparation. |
2013 |
Drug Dev Ind Pharm |
pmid:22591175
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Luo CF et al. |
Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles. |
2013 |
Int J Nanomedicine |
pmid:23486407
|
Cao L et al. |
Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration. |
2013 |
Fitoterapia |
pmid:23500385
|
Guo C et al. |
Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. |
2013 |
Food Chem. Toxicol. |
pmid:23500774
|
Liu CM et al. |
Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase. |
2013 |
Environ. Toxicol. Pharmacol. |
pmid:23501611
|
Cheng M et al. |
Puerarin accelerates re-endothelialization in a carotid arterial injury model: impact on vasodilator concentration and vascular cell functions. |
2013 |
J. Cardiovasc. Pharmacol. |
pmid:23792702
|
Xu L et al. |
Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect. |
2013 |
Phytomedicine |
pmid:23856441
|
Li R et al. |
Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats. |
2013 |
Brain Res. |
pmid:23603411
|
Zhang E et al. |
[Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound]. |
2013 |
Zhongguo Zhong Yao Za Zhi |
pmid:23596875
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Li N et al. |
Determination of glibenclamide and puerarin in rat plasma by UPLC-MS/MS: application to their pharmacokinetic interaction study. |
2013 |
Talanta |
pmid:23597896
|
Wang Y et al. |
Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation. |
2013 |
Phytomedicine |
pmid:23639192
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Chen F et al. |
Puerarin-induced immune hemolytic anemia. |
2013 |
Int. J. Hematol. |
pmid:23661032
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Cao WL et al. |
[Effect of puerarin on hemorheology and pulmonary pressure in rat pneumo-cardiac disease]. |
2013 |
Zhongguo Ying Yong Sheng Li Xue Za Zhi |
pmid:23662397
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Huang ZG et al. |
[Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]. |
2013 |
Zhongguo Zhong Yao Za Zhi |
pmid:23668014
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Zhang Y et al. |
Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs. |
2013 |
Int. J. Neurosci. |
pmid:23668913
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Chen X et al. |
Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats. |
2013 |
Phytomedicine |
pmid:23669266
|
Wang Q et al. |
Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography. |
2013 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:23246846
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Peng JH et al. |
Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. |
2013 |
J. Pharmacol. Exp. Ther. |
pmid:23277536
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Nakamura K et al. |
Enzymatic cleavage of the C-glucosidic bond of puerarin by three proteins, Mn(2+), and oxidized form of nicotinamide adenine dinucleotide. |
2013 |
Biol. Pharm. Bull. |
pmid:23328408
|
Tao HQ et al. |
HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. |
2013 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:23192284
|
Yin R et al. |
UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. |
2013 |
J Pharm Biomed Anal |
pmid:23146236
|
Li R et al. |
Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. |
2013 |
Food Chem. Toxicol. |
pmid:23146695
|
Zou Y et al. |
Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway. |
2013 |
Free Radic. Res. |
pmid:23088308
|
Wang Y et al. |
In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. |
2013 |
Int J Pharm |
pmid:23089583
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Zhang J et al. |
Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors. |
2013 |
Burns |
pmid:23044342
|
Bai S et al. |
Effects of felodipine combined with puerarin on ACE2-Ang (1-7)-Mas axis in renovascular hypertensive rat. |
2013 |
Regul. Pept. |
pmid:23523569
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Tian F et al. |
The neuroprotective mechanism of puerarin treatment of acute spinal cord injury in rats. |
2013 |
Neurosci. Lett. |
pmid:23570727
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Li R et al. |
Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway. |
2013 |
Brain Res. |
pmid:23747813
|
Li R et al. |
Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3β/NF-κB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats. |
2013 |
Int. Immunopharmacol. |
pmid:23751897
|
Liu X et al. |
Pharmacokinetic comparisons of puerarin, daidzin and the glucuronide metabolite of puerarin after administration of total flavonoid from Gegen alone and total flavonoid from Gegen combined with total saponin from Sanqi in rats under different physiological states. |
2013 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:23774247
|
Wong KH et al. |
Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA). |
2013 |
J Pharm Biomed Anal |
pmid:23777642
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Xia DZ et al. |
Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. |
2013 |
Food Chem. Toxicol. |
pmid:23764356
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Wang L et al. |
Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats. |
2013 |
Hum Exp Toxicol |
pmid:23315276
|
Wu K et al. |
Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. |
2013 |
Food Chem. Toxicol. |
pmid:23927877
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Wu X et al. |
Isolation, identification and pharmacokinetic analysis of fructosyl puerarins from enzymatic glycosylation. |
2013 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:23948238
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Cheng Y et al. |
Effects of puerarin on cardiac differentiation and ventricular specialization of murine embryonic stem cells. |
2013 |
Cell. Physiol. Biochem. |
pmid:24080853
|
Zhao LX et al. |
The permeability of puerarin loaded poly(butylcyanoacrylate) nanoparticles coated with polysorbate 80 on the blood-brain barrier and its protective effect against cerebral ischemia/reperfusion injury. |
2013 |
Biol. Pharm. Bull. |
pmid:23902970
|
Ji M et al. |
Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α. |
2013 |
J. Steroid Biochem. Mol. Biol. |
pmid:23907019
|
Tu L et al. |
Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat. |
2013 |
Int J Pharm |
pmid:24120729
|
Cui YH et al. |
[Adsorption and isolation of macroporous resin for three isoflavonoids from puerariae lobatae radix]. |
2013 |
Zhong Yao Cai |
pmid:24134015
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Singh AK et al. |
Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. |
2013 |
J Med Food |
pmid:24138167
|
Jiang L et al. |
Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. |
2013 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:23314488
|
Liu AC et al. |
LC-MS/MS method for the determination of a new puerarin derivative and its application in pharmacokinetic studies in rats. |
2013 |
Chin J Nat Med |
pmid:24359785
|
Zhu H et al. |
Effect of puerarin on matrix metalloproteinase-2 in human fetal scleral fibroblasts treated with low frequency electromagnetic fields. |
2013 |
J Tradit Chin Med |
pmid:24660593
|
Tang TT et al. |
Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach. |
2013 |
Int J Nanomedicine |
pmid:24277986
|
Ji O et al. |
[Effect of flavonoids of puerarin on the proliferation and apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line NB4-R1 cells]. |
2013 |
Zhonghua Xue Ye Xue Za Zhi |
pmid:23688762
|
Gu L et al. |
Polyamidomine dendrimers: an excellent drug carrier for improving the solubility and bioavailability of puerarin. |
2013 Sep-Oct |
Pharm Dev Technol |
pmid:22303809
|
Liu M et al. |
Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord. |
2014 |
Mediators Inflamm. |
pmid:25089076
|
Wang L et al. |
Puerarin facilitates T-tubule development of murine embryonic stem cell-derived cardiomyocytes. |
2014 |
Cell. Physiol. Biochem. |
pmid:25059232
|
Qu Q et al. |
Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro. |
2014 |
Acta Pharmacol. Sin. |
pmid:24786236
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Shao J et al. |
Spectroscopic and molecular docking studies of the in vitro interaction between puerarin and cytochrome P450. |
2014 |
Molecules |
pmid:24743933
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Liu Y et al. |
Amelioration of stroke-induced neurological deficiency by lyophilized powder of catapol and puerarin. |
2014 |
Int. J. Biol. Sci. |
pmid:24719562
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Ma JQ et al. |
Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway. |
2014 |
Basic Clin. Pharmacol. Toxicol. |
pmid:24698568
|
Chen G et al. |
Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways. |
2014 |
Acta Pharmacol. Sin. |
pmid:24608673
|
Li B et al. |
Puerarin enhances bone mass by promoting osteoblastogenesis and slightly lowering bone marrow adiposity in ovariectomized rats. |
2014 |
Biol. Pharm. Bull. |
pmid:25590084
|
Jung HR et al. |
Simultaneous determination of puerarin and its active metabolite in human plasma by UPLC-MS/MS: application to a pharmacokinetic study. |
2014 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:25264914
|
Zhang X et al. |
Puerarin protects dopaminergic neurons in Parkinson's disease models. |
2014 |
Neuroscience |
pmid:25218963
|
Yan Y et al. |
Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry. |
2014 |
J Pharm Biomed Anal |
pmid:24637051
|
Wang S et al. |
Efficient glycosylation of puerarin by an organic solvent-tolerant strain of Lysinibacillus fusiformis. |
2014 |
Enzyme Microb. Technol. |
pmid:24629266
|
Li H et al. |
Biopharmaceutics classification of puerarin and comparison of perfusion approaches in rats. |
2014 |
Int J Pharm |
pmid:24607203
|
She S et al. |
Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. |
2014 |
Food Funct |
pmid:24595557
|
Liu G et al. |
Puerarin protects against lead-induced cytotoxicity in cultured primary rat proximal tubular cells. |
2014 |
Hum Exp Toxicol |
pmid:24505050
|
Tang L et al. |
The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. |
2014 |
Cell Biochem. Funct. |
pmid:24496955
|
Tang F et al. |
Puerarin protects against Staphylococcus aureus-induced injury of human alveolar epithelial A549 cells via downregulating alpha-hemolysin secretion. |
2014 |
Microb. Drug Resist. |
pmid:24372183
|
Zhou Y et al. |
Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. |
2014 |
Int. J. Neuropsychopharmacol. |
pmid:24345484
|
Wang N et al. |
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. |
2014 |
Neuropharmacology |
pmid:24333675
|
Liu Q et al. |
MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate. |
2014 |
Pharm. Res. |
pmid:24242937
|
Li Z et al. |
Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. |
2014 |
J. Mol. Endocrinol. |
pmid:24827001
|
Guo YJ et al. |
In vivo inhibitory effects of puerarin on selected rat cytochrome P450 isoenzymes. |
2014 |
Pharmazie |
pmid:24855829
|
Wu J et al. |
Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials. |
2014 |
J Tradit Chin Med |
pmid:25185357
|
Liu S et al. |
Puerarin blocks the signaling transmission mediated by P2X3 in SG and DRG to relieve myocardial ischemic damage. |
2014 |
Brain Res. Bull. |
pmid:24447636
|
Xu J et al. |
A new flavonoid glycoside from the rhizomes and roots of Smilax scobinicaulis. |
2014 |
Nat. Prod. Res. |
pmid:24483603
|
Mahdy HM et al. |
Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: possible neuromodulation and antioxidant mechanisms. |
2014 |
Neurochem. Res. |
pmid:24346712
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Zhou YX et al. |
Puerarin: a review of pharmacological effects. |
2014 |
Phytother Res |
pmid:24339367
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