| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cherdshewasart W et al. | Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata. | 2007 | J Pharm Biomed Anal | pmid:16930918 |
| Xi J and Guo R | Acid-base equilibrium of puerarin in CTAB micelles. | 2007 | J Pharm Biomed Anal | pmid:16935449 |
| Prasain JK et al. | Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry. | 2007 | Biomed. Chromatogr. | pmid:17221935 |
| Wu C et al. | Preparation and evaluation of a Carbopol/HPMC-based in situ gelling ophthalmic system for puerarin. | 2007 | Yakugaku Zasshi | pmid:17202799 |
| Rachoń D et al. | Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. | 2007 | Maturitas | pmid:17258874 |
| Singh AK et al. | Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. | 2007 | J Med Food | pmid:17887948 |
| Xu XH et al. | Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. | 2007 | Biomed. Environ. Sci. | pmid:17948770 |
| Cherdshewasart W and Sriwatcharakul S | Major isoflavonoid contents of the 1-year-cultivated phytoestrogen-rich herb, Pueraria mirifica. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17928711 |
| Yue PF et al. | Development and optimization of intravenous puerarin emulsions formation by a novel complex-phase inversion-homogenization technology. | 2007 | Chem. Pharm. Bull. | pmid:17978512 |
| Xiao J et al. | Analysis of binding interaction between puerarin and bovine serum albumin by multi-spectroscopic method. | 2007 | J Pharm Biomed Anal | pmid:17942262 |
| Quan DQ and Xu GX | Formulation optimization of self-emulsifying preparations of puerarin through self-emulsifying performances evaluation in vitro and pharmacokinetic studies in vivo. | 2007 | Yao Xue Xue Bao | pmid:17944241 |
| Qi H et al. | Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin. | 2007 | Int J Pharm | pmid:17254725 |
| Wong R and Rabie B | Effect of puerarin on bone formation. | 2007 | Osteoarthr. Cartil. | pmid:17379543 |
| Han RM et al. | Puerarin and conjugate bases as radical scavengers and antioxidants: molecular mechanism and synergism with beta-carotene. | 2007 | J. Agric. Food Chem. | pmid:17300199 |
| Yu Z et al. | HPLC determination of safflor yellow A and three active isoflavones from TCM Naodesheng in rat plasma and tissues and its application to pharmacokinetic studies. | 2007 | Biomed. Chromatogr. | pmid:17385809 |
| Zhao T et al. | The mechanism of 3-methoxy puerarin on decreasing the cerebral ischemia-reperfusion injury in rats. | 2007 | Asia Pac J Clin Nutr | pmid:17392123 |
| Wang HG et al. | [Preparation and characterization of chitosan coated puerarin liposomes]. | 2007 | Zhong Yao Cai | pmid:17539312 |
| Yu Z et al. | Simultaneous determination of safflor yellow A, puerarin, daidzein, ginsenosides (Rg(1), Rb(1), Rd), and notoginsenoside R(1) in rat plasma by liquid chromatography-mass spectrometry. | 2007 | J Pharm Biomed Anal | pmid:17590558 |
| Zhang Y et al. | Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts. | 2007 | Planta Med. | pmid:17443435 |
| Gao R et al. | Gradient high-performance liquid chromatography for the simultaneous determination of chlorogenic acid and baicalin in plasma and its application in the study of pharmacokinetics in rats. | 2007 | J Pharm Biomed Anal | pmid:16859859 |
| Yang H et al. | [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161289 |
| Liu R et al. | [Inhibitory effect of quercetin, rutin and puerarin on LDL oxidation induced by Cu2+]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161305 |
| Lu Y et al. | [Pharmacokinetics of pueraria for intranasal on spray in rabbits]. | 2007 | Zhong Yao Cai | pmid:18236755 |
| Wu L et al. | Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats. | 2007 | Phytomedicine | pmid:17870452 |
| Xu X and Zheng X | Potential involvement of calcium and nitric oxide in protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons. | 2007 | J Ethnopharmacol | pmid:17698307 |
| Yue PF et al. | [Preparation and characterization of the puerarin submicron emulsion]. | 2007 | Yao Xue Xue Bao | pmid:17702404 |
| Gao Q et al. | Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. | 2007 | Eur. J. Pharmacol. | pmid:17692311 |
| Ding MP et al. | [Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia/reperfusion in rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330247 |
| Guo Y et al. | [Study on effect of different combinations of traditional Chinese medicine preparation active parts on metabolism of puerarin in plasma of rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330251 |
| Dong-Qin Q et al. | Formulation development and pharmacokinetics of puerarin self-emulsifying drug delivery systems. | 2007 Jan-Feb | PDA J Pharm Sci Technol | pmid:17390702 |
| He H et al. | The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. | 2008 | Phytother Res | pmid:18389490 |
| Kim YS et al. | Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. | 2008 | J. Microbiol. Biotechnol. | pmid:18600055 |
| Chen JW et al. | [Molecular mechanism of reversing multi-drug resistance of K562/AO2 by puerarin]. | 2008 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:18382055 |
| Wong RW and Rabie AB | Effect of quercetin on preosteoblasts and bone defects. | 2008 | Open Orthop J | pmid:19461927 |
| Mukherjee B et al. | Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers. | 2008 | Int J Nanomedicine | pmid:19337417 |
| Yang B et al. | [Mitochondrial mechanism of cardioprotective effect of puerarin against H202-stress in rats]. | 2008 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21158136 |
| Li QX et al. | [Effect of compound Puerarin on the collage IV in streptozotocin-induced diabetic nephropathy rats]. | 2008 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:18763636 |
| Hwang YP and Jeong HG | Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18845176 |
| Wang YG et al. | [High-performance capillary electrophoresis for determining the chemical compositions of Gegen and Fenge extracts]. | 2008 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:18753072 |
| Li YW et al. | Regulation of aromatase P450 expression by puerarin in endometrial cell line RL95-2. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18847535 |
| Yu C et al. | Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. | 2008 | Food Chem. Toxicol. | pmid:18848966 |
| Jiang JR et al. | Conversion of puerarin into its 7-O-glycoside derivatives by Microbacterium oxydans (CGMCC 1788) to improve its water solubility and pharmacokinetic properties. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18795283 |
| Zhang H et al. | Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection. | 2008 | J Pharm Biomed Anal | pmid:18977108 |
| Pan HP and Li G | Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury. | 2008 | Yakugaku Zasshi | pmid:18981705 |
| Clarke DB et al. | Determination of phytoestrogens in dietary supplements by LC-MS/MS. | 2008 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:18478479 |
| Huang J et al. | Selective adsorption of tannin from flavonoids by organically modified attapulgite clay. | 2008 | J. Hazard. Mater. | pmid:18433994 |
| Cherdshewasart W and Sutjit W | Correlation of antioxidant activity and major isoflavonoid contents of the phytoestrogen-rich Pueraria mirifica and Pueraria lobata tubers. | 2008 | Phytomedicine | pmid:17890070 |
| He Y et al. | Binding of puerarin to human serum albumin: a spectroscopic analysis and molecular docking. | 2008 | J Fluoresc | pmid:18058205 |
| Tian YX et al. | Radical dynamics of puerarin as revealed by laser flash photolysis and spin density analysis. | 2008 | J Phys Chem B | pmid:18232684 |
| Chung MJ et al. | Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. | 2008 | Eur. J. Pharmacol. | pmid:17976573 |