| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Park SJ et al. | Effects of mixed herbal extracts from parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix (KIOM-79) on cardiac ion channels and action potentials. | 2009 | J. Korean Med. Sci. | pmid:19543501 |
| Zhang BQ and Wang YL | [Effects of puerarin on hippocampal synaptic long term potentiation in vascular dementia rats]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21155222 |
| Teng Y et al. | Protective effect of puerarin on diabetic retinopathy in rats. | 2009 | Mol. Biol. Rep. | pmid:18587665 |
| Wu HQ et al. | Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats. | 2009 | Chin J Integr Med | pmid:19271171 |
| Chang Y et al. | Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats. | 2009 | J. Biomed. Sci. | pmid:19272172 |
| Lau CC et al. | Rapid analysis of Radix puerariae by near-infrared spectroscopy. | 2009 | J Chromatogr A | pmid:19185872 |
| Zhang H and Yang X | Profiling and quantification of isoflavone-C-glycosides impurities in puerarin injection by liquid chromatography coupled to ESI-ion trap mass spectrometry. | 2009 | J Pharm Biomed Anal | pmid:19186018 |
| Yan LP et al. | Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19190894 |
| Zheng P et al. | Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. | 2009 | Am. J. Chin. Med. | pmid:19222113 |
| Zhu CQ et al. | [Preparation technology of Zhangyanming dispersible tablet and determination of puerarin by HPLC]. | 2009 | Zhong Yao Cai | pmid:19771855 |
| Han J et al. | [Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19771877 |
| Xu C et al. | Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat. | 2009 | Brain Res. Bull. | pmid:19744545 |
| Cheng YF et al. | Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP(+)-elicited apoptosis. | 2009 | Neurosci. Res. | pmid:19022306 |
| Prasain JK et al. | Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry. | 2009 | Phytomedicine | pmid:19027277 |
| Wu H et al. | Enhanced oral bioavailability of puerarin using microemulsion vehicle. | 2009 | Drug Dev Ind Pharm | pmid:19040180 |
| Lin YJ et al. | Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19013426 |
| Yu CQ et al. | [Regulatory mechanism of malignant behavior of endometriosis mediated by puerarin]. | 2009 | Zhong Xi Yi Jie He Xue Bao | pmid:19134456 |
| Shen JG et al. | Effects of puerarin on receptor for advanced glycation end products in nephridial tissue of streptozotocin-induced diabetic rats. | 2009 | Mol. Biol. Rep. | pmid:19125353 |
| Qin F et al. | Pharmacokinetic comparison of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia: influence of disease state. | 2009 | J. Pharm. Pharmacol. | pmid:19126307 |
| Chen AZ et al. | Microencapsulation of puerarin nanoparticles by poly(l-lactide) in a supercritical CO(2) process. | 2009 | Acta Biomater | pmid:19463980 |
| Jin G et al. | [Effects of puerarin on expression of apelin and its receptor of 2K1C renal hypertension rats]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20353015 |
| Yang L et al. | [Screening and identification of a fungal strain functioning in hydroxylation of puerarin]. | 2009 | Wei Sheng Wu Xue Bao | pmid:20222440 |
| Jiang XX et al. | [Effect of puerarin preconditioning on cytokine levels in patients undergoing cardiopulmonary bypass in perioperative period]. | 2009 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:20214329 |
| Han MX et al. | [Identification of three-step IR spectra of radix Puerariae from different habitats]. | 2009 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:19798956 |
| Yang S et al. | [Effect of puerarin on liver injury in KKAy mice with type 2 diabetes mellitus]. | 2009 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19848202 |
| Gao L et al. | [Of berberine and puerarin on dexamethasone-induced insulin resistance in porcine ovarian thecal cells]. | 2009 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19852296 |
| Han J et al. | [Inhibitory effects of puerarin on invasion and metastasis of oophoroma cells HO-8910]. | 2009 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19852298 |
| Liu XJ et al. | [Study on absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model]. | 2009 | Zhong Yao Cai | pmid:19960950 |
| Wang L et al. | [The pathway of absorption and conveying of puerarin microemulsion-in-oil]. | 2009 | Yao Xue Xue Bao | pmid:19806923 |
| Zhang X et al. | [Pharmacokinetics of puerarin and hydrochlorothiazide from maijunan tablets in rats]. | 2009 | Yao Xue Xue Bao | pmid:20055185 |
| Xiao J et al. | Glycosylation of dietary flavonoids decreases the affinities for plasma protein. | 2009 | J. Agric. Food Chem. | pmid:19722570 |
| Retraction. The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. | 2009 | Phytother Res | pmid:19391125 | |
| Retraction. Cardioprotective effects of the combined use of puerarin and danshensu on acute ischemic myocardial injury in rats. | 2009 | Phytother Res | pmid:19391124 | |
| Lu N et al. | Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. | 2009 | Toxicol In Vitro | pmid:19286453 |
| Derda M et al. | Plant extracts as natural amoebicidal agents. | 2009 | Parasitol. Res. | pmid:19050923 |
| Tian J and Qin W | Quick and sensitive determination of flavonoids by capillary electrophoresis-potential gradient detection. | 2009 | Anal Sci | pmid:19745540 |
| Li Q et al. | Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy. | 2009 Jan-Feb | Natl Med J India | pmid:19761151 |
| Meng XH et al. | Puerarin protects against high glucose-induced acute vascular dysfunction: role of heme oxygenase-1 in rat thoracic aorta. | 2009 Mar-Apr | Vascul. Pharmacol. | pmid:19073281 |
| Zhang W et al. | Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. | 2010 | Eur. J. Pharmacol. | pmid:20869961 |
| Zhang HY et al. | [The protective effect of puerarin on Abeta(25-35)-induced PC12 cell injury]. | 2010 | Zhong Yao Cai | pmid:20873562 |
| Zhang XP et al. | Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis. | 2010 | Methods Find Exp Clin Pharmacol | pmid:21225014 |
| Wang L and Zhao Y | [Effect of decoction method on pharmacokinetics of puerarin in dogs]. | 2010 | Zhong Yao Cai | pmid:21243776 |
| Semalty A et al. | Development and evaluation of pharmacosomes of aceclofenac. | 2010 | Indian J Pharm Sci | pmid:21694988 |
| Gao C et al. | Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats. | 2010 | J. Pharm. Pharmacol. | pmid:20487220 |
| Zhang H et al. | Investigation of the inclusions of puerarin and daidzin with beta-cyclodextrin by molecular dynamics simulation. | 2010 | J Phys Chem B | pmid:20297792 |
| Kato E and Kawabata J | Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20605096 |
| Liu X et al. | A validated stability-indicating HPLC method for the determination of PEGylated puerarin in aqueous solutions. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20580327 |
| Zhang R et al. | [Protective effect of puerarin against calcium overload after focal cerebral ischemia injury in rats]. | 2010 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:20584654 |
| Yao W et al. | Preparation and characterization of puerarin-dendrimer complexes as an ocular drug delivery system. | 2010 | Drug Dev Ind Pharm | pmid:20545508 |
| Fan X et al. | Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. | 2010 | Curr Neuropharmacol | pmid:21629441 |