SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
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What lipids are associated with SCHEMBL105486?
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xu XH and Zhang ZG | [Effect of puerarin on learning-memory behavior and synaptic structure of hippocampus in the aging mice induced by D-galactose]. | 2002 | Yao Xue Xue Bao | pmid:12579889 |
| Hsu FL et al. | Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. | 2003 | J. Nat. Prod. | pmid:12828463 |
| Shi HP and Kintzios S | Genetic transformation of Pueraria phaseoloides with Agrobacterium rhizogenes and puerarin production in hairy roots. | 2003 | Plant Cell Rep. | pmid:12836005 |
| Jin M et al. | [Clinical study on Tianbaokang injection against oxidative injury of vascular endothelial function in ischemic apoplexy]. | 2003 | Zhong Yao Cai | pmid:12795227 |
| Shi RL and Zhang JJ | [Protective effect of puerarin on vascular endothelial cell apoptosis induced by chemical hypoxia in vitro]. | 2003 | Yao Xue Xue Bao | pmid:12778743 |
| Li X et al. | Experimental study on the protective effect of puerarin to Parkinson disease. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:12973933 |
| Pan HP et al. | [Experimental study of puerarin injection on the hemorheology in acute blood-stasis model rats]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617506 |
| Bae HS et al. | Hepatoprotective activity of reduohanxiao-tang (yuldahanso-tang) is related to the inhibition of beta-glucuronidase. | 2003 | Am. J. Chin. Med. | pmid:12723760 |
| Jin WS et al. | [Determination of puerarin, daidzin and daidzein in root of Pueraria lobata of different origin by HPLC]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015267 |
| Overstreet DH et al. | NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. | 2003 | Pharmacol. Biochem. Behav. | pmid:12895679 |
| Li B and Yu S | [Effect of puerarin on the bone metabolism in vitro]. | 2003 | Beijing Da Xue Xue Bao | pmid:12920814 |
| Jiang B et al. | Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarin. | 2003 | Cell Biol. Int. | pmid:14642535 |
| Zhang GQ et al. | Puerarin blocks Na+ current in rat ventricular myocytes. | 2003 | Acta Pharmacol. Sin. | pmid:14653946 |
| Matkowski A et al. | Flavonoids of Pueraria lobata: chromatographic analysis of leaves and roots of cultivated plants. | 2003 | Pharmazie | pmid:14531473 |
| Shi HP et al. | [Culture of hairy roots in Pueraria phaseoloides and its puerarin production]. | 2003 | Shi Yan Sheng Wu Xue Bao | pmid:14724930 |
| Xie RQ et al. | [Myocardial protection and mechanism of Puerarin Injection on patients of coronary heart disease with ischemia/reperfusion]. | 2003 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:14714357 |
| Xu XH | [Effects of puerarin on fatty superoxide in aged mice induced by D-galactose]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015271 |
| Rezvani AH et al. | Plant derivatives in the treatment of alcohol dependency. | 2003 | Pharmacol. Biochem. Behav. | pmid:12895677 |
| Prasain JK et al. | Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. | 2003 | J. Agric. Food Chem. | pmid:12848487 |
| Overstreet DH et al. | Herbal remedies for alcoholism: promises and possible pitfalls. | 2003 | Alcohol. Clin. Exp. Res. | pmid:12605067 |
| Dong K et al. | [Endothelium-independent vasorelaxant effect of puerarin on rat thoracic aorta]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15631089 |
| Chauhan SK et al. | Determination of puerarin from pueraria tuberosa dc by HPLC. | 2004 | Anc Sci Life | pmid:22557128 |
| Chueh FS et al. | Puerarin acts through brain serotonergic mechanisms to induce thermal effects. | 2004 | J. Pharmacol. Sci. | pmid:15599109 |
| Chen WC et al. | Mediation of beta-endorphin by the isoflavone puerarin to lower plasma glucose in streptozotocin-induced diabetic rats. | 2004 | Planta Med. | pmid:14994187 |
| Wang B et al. | [Clinical analysis of 5 cases with acute intravascular hemolysis caused by puerarin]. | 2004 | Beijing Da Xue Xue Bao | pmid:14970887 |
| Zhang FR et al. | [Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506293 |
| Zhang Q et al. | Flow injection-chemiluminescence determination of puerarin in pharmaceutical preparations. | 2004 | J Pharm Biomed Anal | pmid:15522534 |
| Duan HJ et al. | [Effects of puerarin on renal function, expressions of MMP-2 and TIMP-2 in diabetic rats]. | 2004 | Yao Xue Xue Bao | pmid:15493832 |
| Xiao LZ et al. | [Study on the effect and mechanism of puerarin on the size of infarction in patients with acute myocardial infarction]. | 2004 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15495821 |
| Prasain JK et al. | Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry. | 2004 | J. Agric. Food Chem. | pmid:15186086 |
| Sang HF et al. | Effect of puerarin on neural function and histopathological damages after transient spinal cord ischemia in rabbits. | 2004 | Chin. J. Traumatol. | pmid:15294110 |
| Song CY and Bi HM | [Effects of puerarin on plasma membrane GLUT4 content in skeletal muscle from insulin-resistant Sprague-Dawley rats under insulin stimulation]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15719689 |
| Benlhabib E et al. | Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. | 2004 | J Med Food | pmid:15298765 |
| Guo XG et al. | [Effect of puerarin on L-type calcium channel in isolated rat ventricular myocytes]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706853 |
| Hao LN et al. | [Peroxynitrite-induced formation of diabetic cataract and its prevention by puerarin in rat]. | 2004 | Zhonghua Yan Ke Za Zhi | pmid:15312625 |
| Han J et al. | [Effect of puerarin and daidzein on proliferating vascular smooth muscle cells]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706898 |
| Zhu JH et al. | Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood. | 2004 | Acta Pharmacol. Sin. | pmid:15301738 |
| Xu X et al. | Effects of puerarin on learning-memory and amino acid transmitters of brain in ovariectomized mice. | 2004 | Planta Med. | pmid:15303253 |
| Wang C and Song Z | In vitro monitoring of nanogram levels of puerarin in human urine using flow injection chemiluminescence. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15261255 |
| Li D et al. | In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase. | 2004 | Carbohydr. Res. | pmid:15542087 |
| Kintzios S et al. | Scale-up production of puerarin from hairy roots of Pueraria phaseoloides in an airlift bioreactor. | 2004 | Biotechnol. Lett. | pmid:15218379 |
| He X et al. | Purification of the isoflavonoid puerarin by adsorption chromatography on cross-linked 12% agarose. | 2004 | J Chromatogr A | pmid:15584227 |
| Chen X | [The clinical observation of puerarin injection on unstable angina pectoris]. | 2004 | Zhong Yao Cai | pmid:15179793 |
| Meng F et al. | [Inhibitory effect of quercetin, rutin and puerarin on HDL oxidation induced by Cu2+]. | 2004 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:15573768 |
| Derda M et al. | [Amebicidal plants extracts]. | 2004 | Wiad Parazytol | pmid:16862806 |
| Dong K et al. | Endothelium-independent vasorelaxant effect of puerarin on rat thoracic aorta. | 2004 | Conf Proc IEEE Eng Med Biol Soc | pmid:17271112 |
| Franke AA et al. | Determinants for urinary and plasma isoflavones in humans after soy intake. | 2004 | Nutr Cancer | pmid:15623460 |
| Benlhabib E et al. | Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. | 2004 | J Med Food | pmid:15298764 |
| Matkowski A | In vitro isoflavonoid production in callus from different organs of Pueraria lobata (Wild.) Ohwi. | 2004 | J. Plant Physiol. | pmid:15077633 |
| Jung DY et al. | Induction of growth hormone release by Pueraria thunbergiana BENTH. | 2004 | Horm. Metab. Res. | pmid:15002057 |