| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Zhao YZ et al. | Using PG-Liposome-Based System to Enhance Puerarin Liver-Targeted Therapy for Alcohol-Induced Liver Disease. | 2016 | AAPS PharmSciTech | pmid:26753818 |
| Cheng G et al. | Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique. | 2016 | AAPS PharmSciTech | pmid:26694058 |
| Yue PF et al. | The study on the entrapment efficiency and in vitro release of puerarin submicron emulsion. | 2009 | AAPS PharmSciTech | pmid:19381837 |
| Chen AZ et al. | Microencapsulation of puerarin nanoparticles by poly(l-lactide) in a supercritical CO(2) process. | 2009 | Acta Biomater | pmid:19463980 |
| Xu J et al. | Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release. | 2010 | Acta Biomater | pmid:19619677 |
| Zhang CP et al. | Genistein-3'-sulfonic acid dihydrate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21583946 |
| Zhang GQ et al. | Puerarin blocks Na+ current in rat ventricular myocytes. | 2003 | Acta Pharmacol. Sin. | pmid:14653946 |
| Mao CP and Gu ZL | Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells. | 2005 | Acta Pharmacol. Sin. | pmid:16038632 |
| Su HF et al. | Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms. | 2016 | Acta Pharmacol. Sin. | pmid:26972494 |
| Zhu JH et al. | Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood. | 2004 | Acta Pharmacol. Sin. | pmid:15301738 |
| Qu Q et al. | Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro. | 2014 | Acta Pharmacol. Sin. | pmid:24786236 |
| Chen G et al. | Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways. | 2014 | Acta Pharmacol. Sin. | pmid:24608673 |
| Xu XH and Zhao TQ | Effects of puerarin on D-galactose-induced memory deficits in mice. | 2002 | Acta Pharmacol. Sin. | pmid:12100749 |
| Zhang GQ et al. | Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. | 2001 | Acta Pharmacol. Sin. | pmid:11742573 |
| Chauhan NS et al. | Spectrofluorimetric estimation of puerarin in Pueraria tuberosa. | 2011 May-Jun | Acta Pol Pharm | pmid:21648202 |
| Lin RC et al. | Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8800381 |
| Overstreet DH et al. | Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8730211 |
| Overstreet DH et al. | Herbal remedies for alcoholism: promises and possible pitfalls. | 2003 | Alcohol. Clin. Exp. Res. | pmid:12605067 |
| Bae HS et al. | Hepatoprotective activity of reduohanxiao-tang (yuldahanso-tang) is related to the inhibition of beta-glucuronidase. | 2003 | Am. J. Chin. Med. | pmid:12723760 |
| Liu R et al. | Pharmacokinetics of puerarin and ginsenoside Rg1 of CBN injection and the relation with platelet aggregation in rats. | 2006 | Am. J. Chin. Med. | pmid:17163592 |
| Zheng P et al. | Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. | 2009 | Am. J. Chin. Med. | pmid:19222113 |
| Zhao M et al. | Protective effect of puerarin on acute alcoholic liver injury. | 2010 | Am. J. Chin. Med. | pmid:20387222 |
| Hsiang SW et al. | Puerarin accelerates peripheral nerve regeneration. | 2011 | Am. J. Chin. Med. | pmid:22083991 |
| Lu Q et al. | Puerarin attenuates calcification of vascular smooth muscle cells. | 2014 | Am. J. Chin. Med. | pmid:24707866 |
| Tan C et al. | Puerarin Improves Vascular Insulin Resistance and Cardiovascular Remodeling in Salt-Sensitive Hypertension. | 2017 | Am. J. Chin. Med. | pmid:28830209 |
| Lin RC and Li TK | Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. | 1998 | Am. J. Clin. Nutr. | pmid:9848526 |
| Wang J et al. | Detection of flavonoids and assay for their antioxidant activity based on enlargement of gold nanoparticles. | 2007 | Anal Bioanal Chem | pmid:17479255 |
| Baranowska I and Magiera S | Analysis of isoflavones and flavonoids in human urine by UHPLC. | 2011 | Anal Bioanal Chem | pmid:20936271 |
| Tian J and Qin W | Quick and sensitive determination of flavonoids by capillary electrophoresis-potential gradient detection. | 2009 | Anal Sci | pmid:19745540 |
| Zeng A et al. | Simultaneous analysis and retention behavior of major isoflavonoids in Radix Puerariae lobatae and Radix Puerariae thomsonii by high performance liquid chromatography with cyclodextrins as a mobile phase modifier. | 2012 | Anal. Chim. Acta | pmid:22177078 |
| Luo J et al. | Molecularly imprinted layer-coated monodisperse spherical silica microparticles toward affinity-enrichment of isoflavonoid glycosides from Radix puerariae. | 2012 | Analyst | pmid:22553769 |
| Chauhan SK et al. | Determination of puerarin from pueraria tuberosa dc by HPLC. | 2004 | Anc Sci Life | pmid:22557128 |
| Zhang WG et al. | Puerarin Induces Hepatocellular Carcinoma Cell Apoptosis Modulated by MAPK Signaling Pathways in a Dose-dependent Manner. | 2017 | Anticancer Res. | pmid:28739736 |
| Romero MR et al. | Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. | 2005 | Antiviral Res. | pmid:16122816 |
| Yang L and Tan T | An enhanced adsorption in puerarin retention on oligo-beta-cyclodextrin grafted poly(glycidyl methacrylate) media. | 2010 | Appl. Biochem. Biotechnol. | pmid:19067245 |
| Jiang JR et al. | Conversion of puerarin into its 7-O-glycoside derivatives by Microbacterium oxydans (CGMCC 1788) to improve its water solubility and pharmacokinetic properties. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18795283 |
| Yu C et al. | Permeabilization of Microbacterium oxylans shifts the conversion of puerarin from puerarin-7-O-glucoside to puerarin-7-O-fructoside. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19943046 |
| Kim JM et al. | Constituents of the roots of Pueraria lobata inhibit formation of advanced glycation end products (AGEs). | 2006 | Arch. Pharm. Res. | pmid:17121174 |
| Kim SJ et al. | Peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants. | 2010 | Arch. Pharm. Res. | pmid:20607491 |
| Kim YS et al. | The role of intestinal microflora on daidzein excretion in urine in humans treated with Chungpesagantang. | 2007 | Arch. Pharm. Res. | pmid:17489365 |
| Zheng J et al. | The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. | 2010 | Arch. Pharm. Res. | pmid:20195825 |
| Jin SE et al. | Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots. | 2012 | Arch. Pharm. Res. | pmid:22644850 |
| Hwang YP et al. | Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. | 2007 | Arch. Pharm. Res. | pmid:18038910 |
| Lee DS et al. | Fecal metabolic activities of herbal components to bioactive compounds. | 2002 | Arch. Pharm. Res. | pmid:12009030 |
| Luo CF et al. | UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes. | 2012 | Arch. Toxicol. | pmid:22648071 |
| Lin F et al. | Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons. | 2012 | Arzneimittelforschung | pmid:22278629 |
| Zhao T et al. | The mechanism of 3-methoxy puerarin on decreasing the cerebral ischemia-reperfusion injury in rats. | 2007 | Asia Pac J Clin Nutr | pmid:17392123 |
| Chen F et al. | Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. | 2012 | Asian Pac J Trop Med | pmid:23146804 |
| Ma JQ et al. | Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24698568 |
| Tang XL et al. | Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarin and 17β-oestradiol in ovariectomized rats. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22333267 |
| Yang X et al. | Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris. | 2010 | Basic Clin. Pharmacol. Toxicol. | pmid:20346059 |
| Wang B et al. | [Clinical analysis of 5 cases with acute intravascular hemolysis caused by puerarin]. | 2004 | Beijing Da Xue Xue Bao | pmid:14970887 |
| Li B and Yu S | [Effect of puerarin on the bone metabolism in vitro]. | 2003 | Beijing Da Xue Xue Bao | pmid:12920814 |
| Cheng W et al. | Puerarin improves cardiac function through regulation of energy metabolism in Streptozotocin-Nicotinamide induced diabetic mice after myocardial infarction. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26079885 |
| Liu B et al. | Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26188094 |
| Noh BK et al. | Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21964292 |
| Lin YJ et al. | Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19013426 |
| Lee JH et al. | The suppressive effect of puerarin on atopic dermatitis-like skin lesions through regulation of inflammatory mediators in vitro and in vivo. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29524423 |
| Liu B et al. | Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29427658 |
| Mercer LD et al. | Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. | 2005 | Biochem. Pharmacol. | pmid:15627486 |
| Vera JC et al. | Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. | 2001 | Biochemistry | pmid:11170395 |
| Deng Y et al. | ERK5/KLF2 activation is involved in the reducing effects of puerarin on monocyte adhesion to endothelial cells and atherosclerotic lesion in apolipoprotein E-deficient mice. | 2018 | Biochim. Biophys. Acta | pmid:29723698 |
| Huang F et al. | Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner. | 2012 | Biochimie | pmid:22314193 |
| Lee OH et al. | Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells. | 2010 Nov-Dec | Biofactors | pmid:20806284 |
| Wang ZK et al. | Alleviation of Lead-Induced Apoptosis by Puerarin via Inhibiting Mitochondrial Permeability Transition Pore Opening in Primary Cultures of Rat Proximal Tubular Cells. | 2016 | Biol Trace Elem Res | pmid:27116952 |
| Mo SF et al. | Hypouricemic action of selected flavonoids in mice: structure-activity relationships. | 2007 | Biol. Pharm. Bull. | pmid:17666819 |
| Zhang Y et al. | Puerarin Prevents LPS-Induced Osteoclast Formation and Bone Loss via Inhibition of Akt Activation. | 2016 | Biol. Pharm. Bull. | pmid:27904045 |
| Kim DH et al. | Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity. | 1998 | Biol. Pharm. Bull. | pmid:9657051 |
| Yao WJ et al. | Effect of poly(amidoamine) dendrimers on corneal penetration of puerarin. | 2010 | Biol. Pharm. Bull. | pmid:20686234 |
| Li B et al. | Puerarin enhances bone mass by promoting osteoblastogenesis and slightly lowering bone marrow adiposity in ovariectomized rats. | 2014 | Biol. Pharm. Bull. | pmid:25590084 |
| Park EK et al. | Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana. | 2006 | Biol. Pharm. Bull. | pmid:17142977 |
| Zhang S et al. | Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. | 2006 | Biol. Pharm. Bull. | pmid:16651724 |
| Jin JS et al. | Biotransformation of C-glucosylisoflavone puerarin to estrogenic (3S)-equol in co-culture of two human intestinal bacteria. | 2008 | Biol. Pharm. Bull. | pmid:18670101 |
| Nakamura K et al. | Enzymatic cleavage of the C-glucosidic bond of puerarin by three proteins, Mn(2+), and oxidized form of nicotinamide adenine dinucleotide. | 2013 | Biol. Pharm. Bull. | pmid:23328408 |
| Zhao LX et al. | The permeability of puerarin loaded poly(butylcyanoacrylate) nanoparticles coated with polysorbate 80 on the blood-brain barrier and its protective effect against cerebral ischemia/reperfusion injury. | 2013 | Biol. Pharm. Bull. | pmid:23902970 |
| Yasuda T et al. | Urinary and biliary metabolites of puerarin in rats. | 1995 | Biol. Pharm. Bull. | pmid:7742802 |
| Yue PF et al. | The study to reduce the hemolysis side effect of puerarin by a submicron emulsion delivery system. | 2008 | Biol. Pharm. Bull. | pmid:18175940 |
| Choo MK et al. | Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora. | 2002 | Biol. Pharm. Bull. | pmid:12392089 |
| Bao L et al. | The anti-atherosclerotic effects of puerarin on induced-atherosclerosis in rabbits. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:24510110 |
| Ji Y et al. | Anticerebral Ischemia-Reperfusion Injury Activity of Synthesized Puerarin Derivatives. | 2016 | Biomed Res Int | pmid:27807543 |
| Zhang H et al. | Puerarin Inhibits oxLDL-Induced Macrophage Activation and Foam Cell Formation in Human THP1 Macrophage. | 2015 | Biomed Res Int | pmid:26576421 |
| Cui S et al. | Study on the bioavailability of puerarin from Pueraria lobata isoflavone self-microemulsifying drug-delivery systems and tablets in rabbits by liquid chromatography-mass spectrometry. | 2005 | Biomed. Chromatogr. | pmid:15627278 |
| Li C et al. | Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations. | 2005 | Biomed. Chromatogr. | pmid:15627280 |
| Sun H et al. | Simultaneous determination of epalrestat and puerarin in rat plasma by UHPLC-MS/MS: Application to their pharmacokinetic interaction study. | 2017 | Biomed. Chromatogr. | pmid:27650591 |
| Yan B et al. | Determination of puerarin in rat cortex by high-performance liquid chromatography after intravenous administration of Puerariae flavonoids. | 2006 | Biomed. Chromatogr. | pmid:16078309 |
| Prasain JK et al. | Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry. | 2007 | Biomed. Chromatogr. | pmid:17221935 |
| Zhu S et al. | Preparation of a super-long two column chromatography system and its application in separating glycosylated puerarin. | 2009 | Biomed. Chromatogr. | pmid:19603387 |
| Krittanai S et al. | Development of a colloidal gold nanoparticle-based immunochromatographic strip for the one-step detection of miroestrol and puerarin. | 2018 | Biomed. Chromatogr. | pmid:29972702 |
| Li Y et al. | Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats. | 2012 | Biomed. Chromatogr. | pmid:22253022 |
| Wen Y et al. | Simultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS. | 2012 | Biomed. Chromatogr. | pmid:21830226 |
| Liu J et al. | An improved LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma and its application to a pharmacokinetic study in patients. | 2010 | Biomed. Chromatogr. | pmid:20058327 |
| Yu Z et al. | HPLC determination of safflor yellow A and three active isoflavones from TCM Naodesheng in rat plasma and tissues and its application to pharmacokinetic studies. | 2007 | Biomed. Chromatogr. | pmid:17385809 |
| Wang Y et al. | Simultaneous determination of four components in Baige capsule by HPLC: application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats. | 2014 | Biomed. Chromatogr. | pmid:24122939 |
| Xu XH et al. | Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. | 2007 | Biomed. Environ. Sci. | pmid:17948770 |
| Dong Z et al. | RGD modified and PEGylated lipid nanoparticles loaded with puerarin: Formulation, characterization and protective effects on acute myocardial ischemia model. | 2017 | Biomed. Pharmacother. | pmid:28236703 |
| Shiying L et al. | Puerarin promoted proliferation and differentiation of dopamine-producing cells in Parkinson's animal models. | 2018 | Biomed. Pharmacother. | pmid:30119192 |
| Deng HF et al. | Puerarin prevents vascular endothelial injury through suppression of NF-κB activation in LPS-challenged human umbilical vein endothelial cells. | 2018 | Biomed. Pharmacother. | pmid:29775893 |
| Liu Q et al. | Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro. | 2018 | Biomed. Pharmacother. | pmid:29710508 |
| Liu X et al. | Puerarin suppresses LPS-induced breast cancer cell migration, invasion and adhesion by blockage NF-κB and Erk pathway. | 2017 | Biomed. Pharmacother. | pmid:28558356 |