| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Fan S et al. | [Effects of both puerarin and gypsum on the firing of pyrogen-treated thermosensitive neurons in the region POAH of anesthetized cats]. | 1997 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:10074325 |
| Dong LP and Wang TY | Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375780 |
| Xuan B et al. | Improvement of ocular blood flow and retinal functions with puerarin analogs. | 1999 | J Ocul Pharmacol Ther | pmid:10385129 |
| Okamura N et al. | Simultaneous high-performance liquid chromatographic determination of puerarin, daidzin, paeoniflorin, liquiritin, cinnamic acid, cinnamaldehyde and glycyrrhizin in Kampo medicines. | 1999 | J Pharm Biomed Anal | pmid:10704126 |
| Guerra MC et al. | Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. | 2000 | Life Sci. | pmid:11133012 |
| Vera JC et al. | Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. | 2001 | Biochemistry | pmid:11170395 |
| Wang L et al. | [Protective effect of puerarin on acute cerebral ischemia in rats]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11243176 |
| Zhao Z et al. | [Clinical study of puerarin in treatment of patients with unstable angina]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477926 |
| Chen G et al. | Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection. | 2001 | J Chromatogr A | pmid:11510548 |
| Jin XL et al. | [Determination of puerarin in plasma by high performance liquid chromatography]. | 1997 | Yao Xue Xue Bao | pmid:11596224 |
| Zhu H et al. | [Application and characteristics of macroreticular resin in purification study of different effective ingredients in Chinese medicines]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599359 |
| Qian Y et al. | Blocking effect of puerarin on calcium channel in isolated guinea pig ventricular myocytes. | 1999 | Chin. Med. J. | pmid:11717945 |
| Zhang GQ et al. | Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. | 2001 | Acta Pharmacol. Sin. | pmid:11742573 |
| Meng P et al. | [Clinical observation of the treatment of infantile viral myocarditis with puerarin]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783152 |
| Chen J et al. | [Effect of puerarin on fibrinolytic activity and lipid peroxide in patients with coronary heart disease]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783153 |
| Ren P et al. | [Observation on efficacy of puerarin in treating diabetic retinopathy]. | 2000 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11789184 |
| Yamaki K et al. | Effects of naturally occurring isoflavones on prostaglandin E2 production. | 2002 | Planta Med. | pmid:11859455 |
| Keyler DE et al. | Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028. | 2002 | J Altern Complement Med | pmid:12006125 |
| Lee DS et al. | Fecal metabolic activities of herbal components to bioactive compounds. | 2002 | Arch. Pharm. Res. | pmid:12009030 |
| Efferth T et al. | Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells. | Blood Cells Mol. Dis. | pmid:12064912 | |
| Xu XH and Zhao TQ | Effects of puerarin on D-galactose-induced memory deficits in mice. | 2002 | Acta Pharmacol. Sin. | pmid:12100749 |
| Liu Q et al. | [Effect of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205891 |
| Jiang B et al. | [Stable life prediction for a complex injection of Chinese materia medica by initial average rate stability test]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12212078 |
| Duan S et al. | [Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure]. | 2000 | Hunan Yi Ke Da Xue Xue Bao | pmid:12212215 |
| Liu S et al. | [A study on processing of the root of Pueraria lobata (Willd.) ohwi by HPLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:12242820 |
| Yu BS et al. | RP-HPLC determination of puerarin in Chinese traditional medicinal preparations containing pueraria. | 2002 | J Pharm Biomed Anal | pmid:12367710 |
| Hsieh MT et al. | Effects of puerarin on scopolamine-, mecamylamine-, p-chloroamphetamine- and dizocilpine-induced inhibitory avoidance performance impairment in rats. | 2002 | Planta Med. | pmid:12391553 |
| Choo MK et al. | Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora. | 2002 | Biol. Pharm. Bull. | pmid:12392089 |
| Liu JM et al. | [Therapeutic effect of puerarin therapy on sudden deafness]. | 2002 | Di Yi Jun Yi Da Xue Xue Bao | pmid:12433647 |
| Hsu HH et al. | Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. | 2002 | Planta Med. | pmid:12451490 |
| Cervellati R et al. | Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. | 2002 | J. Agric. Food Chem. | pmid:12475261 |
| Lee JS et al. | The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells. | 2002 | BMC Complement Altern Med | pmid:12485466 |
| Benlhabib E et al. | Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations. | 2002 | J Med Food | pmid:12495583 |
| Ma YS et al. | [Studies permeation of puerarin and its phospholipid complex through mouse skin in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512448 |
| Peng XY et al. | [Study on the differentiation and apoptosis of HL-60 cell line induced by Puerarin]. | 2001 | Hunan Yi Ke Da Xue Xue Bao | pmid:12536642 |
| Wang YJ et al. | [Determination of beberine hydrochloride and puerarin in tangwei capsules by RP-HPLC of gradient elution method]. | 2000 | Se Pu | pmid:12541715 |
| Wei GL et al. | Endotoxin removal in some medicines and human serum albumin solution by affinity membranes. | 2002 | Se Pu | pmid:12541963 |
| Tian J et al. | [Determination of puerarin in three traditional Chinese patent medicines by high performance liquid chromatography]. | 2001 | Se Pu | pmid:12545446 |
| Fu C et al. | [The study of ethanol-water used as reversed-phase high performance liquid chromatographic mobile phase]. | 1999 | Se Pu | pmid:12552885 |
| Wu P et al. | [Study on effect of Puerarin on nitric oxide system in rats' tissue and its mechanism]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577337 |
| Luo ZR and Zheng B | [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577374 |
| Xu XH and Zhang ZG | [Effect of puerarin on learning-memory behavior and synaptic structure of hippocampus in the aging mice induced by D-galactose]. | 2002 | Yao Xue Xue Bao | pmid:12579889 |
| Shi WG et al. | [Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12585165 |
| Overstreet DH et al. | Herbal remedies for alcoholism: promises and possible pitfalls. | 2003 | Alcohol. Clin. Exp. Res. | pmid:12605067 |
| Bae HS et al. | Hepatoprotective activity of reduohanxiao-tang (yuldahanso-tang) is related to the inhibition of beta-glucuronidase. | 2003 | Am. J. Chin. Med. | pmid:12723760 |
| Zhu ZT et al. | [Inhibitive effect of puerarin on increased NO production by neonatal cardiomyocytes during hypoxia/reoxygenation injury]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776339 |
| Huang YF et al. | [Determination of puerarin in xinmaitong oral liquid by HPLC]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776346 |
| Qi BL and Qi BM | [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12776591 |
| Shi RL and Zhang JJ | [Protective effect of puerarin on vascular endothelial cell apoptosis induced by chemical hypoxia in vitro]. | 2003 | Yao Xue Xue Bao | pmid:12778743 |