| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen X et al. | Puerarin attenuates palmitate-induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes. | 2018 | Life Sci. | pmid:29802940 |
| Wan Q et al. | Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway. | 2018 | BMC Complement Altern Med | pmid:29728095 |
| Deng Y et al. | ERK5/KLF2 activation is involved in the reducing effects of puerarin on monocyte adhesion to endothelial cells and atherosclerotic lesion in apolipoprotein E-deficient mice. | 2018 | Biochim. Biophys. Acta | pmid:29723698 |
| Lee JH et al. | The suppressive effect of puerarin on atopic dermatitis-like skin lesions through regulation of inflammatory mediators in vitro and in vivo. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29524423 |
| Chen G et al. | Puerarin attenuates angiotensin II-induced cardiac fibroblast proliferation via the promotion of catalase activity and the inhibition of hydrogen peroxide-dependent Rac-1 activation. | 2018 | Chin J Nat Med | pmid:29425589 |
| Hu Y et al. | Puerarin inhibits non-small cell lung cancer cell growth via the induction of apoptosis. | 2018 | Oncol. Rep. | pmid:29393465 |
| Zeng X et al. | Puerarin inhibits TRPM3/miR-204 to promote MC3T3-E1 cells proliferation, differentiation and mineralization. | 2018 | Phytother Res | pmid:29368357 |
| Fu C et al. | Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1/2‑Nrf2 signaling pathway. | 2018 | Mol Med Rep | pmid:29359784 |
| Yang B et al. | Influence of paeoniflorin and menthol on puerarin transport across MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model. | 2018 | J. Pharm. Pharmacol. | pmid:29238980 |
| Li Y et al. | Effect of puerarin on collagen metabolism of fibroblasts in pelvic tissue of women with pelvic organ prolapse. | 2018 | Mol Med Rep | pmid:29207080 |
| Zhong Y et al. | Puerarin alleviate radicular pain from lumbar disc herniation by inhibiting ERK-dependent spinal microglia activation. | 2018 | Neuropeptides | pmid:30466510 |
| Li SW et al. | Comparison on Anticoagulation and Antiplatelet Aggregation Effects of Puerarin with Heparin Sodium and Tirofiban Hydrochloride: An In Vitro Study. | 2018 | Chin J Integr Med | pmid:29067595 |
| Wang Y et al. | Support Vector Regression Approach to Predict the Design Space for the Extraction Process of . | 2018 | Molecules | pmid:30241281 |
| Chen X et al. | Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving μ-opioid receptor. | 2018 | Eur. J. Pharmacol. | pmid:29061371 |
| Shiying L et al. | Puerarin promoted proliferation and differentiation of dopamine-producing cells in Parkinson's animal models. | 2018 | Biomed. Pharmacother. | pmid:30119192 |
| Hou B et al. | Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF- Signaling Pathway Activation in Type 2 Diabetic Rats. | 2018 | Oxid Med Cell Longev | pmid:30057680 |
| Pang Z et al. | Gel formation of puerarin and mechanistic study during its cooling process. | 2018 | Int J Pharm | pmid:30016673 |
| Krittanai S et al. | Development of a colloidal gold nanoparticle-based immunochromatographic strip for the one-step detection of miroestrol and puerarin. | 2018 | Biomed. Chromatogr. | pmid:29972702 |
| Wang L et al. | Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-γ Coactivator-1 Signaling Pathway in Osteoarthritis Rats. | 2018 | Pharmacology | pmid:29961054 |
| Ullah MZ et al. | Attenuation of inflammatory pain by puerarin in animal model of inflammation through inhibition of pro-inflammatory mediators. | 2018 | Int. Immunopharmacol. | pmid:29909234 |
| Deng HF et al. | Puerarin prevents vascular endothelial injury through suppression of NF-κB activation in LPS-challenged human umbilical vein endothelial cells. | 2018 | Biomed. Pharmacother. | pmid:29775893 |
| Loutchanwoot P and Vortherms T | Effects of puerarin on estrogen-regulated gene expression in gonadotropin-releasing hormone pulse generator of ovariectomized rats. | 2018 | Steroids | pmid:29733861 |
| Liu Q et al. | Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro. | 2018 | Biomed. Pharmacother. | pmid:29710508 |
| Wei HY et al. | Puerarin regulates neovascular glaucoma through pigment epithelium‑derived growth factor‑induced NF‑κB signaling pathway. | 2018 | Mol Med Rep | pmid:29620183 |
| Wang S et al. | Optimization of ionic liquids-based microwave-assisted hydrolysis of puerarin and daidzein derivatives from Radix Puerariae Lobatae extract. | 2018 | Food Chem | pmid:29606431 |
| Li W et al. | Puerarin-loaded PEG-PE micelles with enhanced anti-apoptotic effect and better pharmacokinetic profile. | 2018 | Drug Deliv | pmid:29587545 |
| Wang X et al. | Puerarin prevents LPS-induced acute lung injury via inhibiting inflammatory response. | 2018 | Microb. Pathog. | pmid:29571724 |
| Guo BQ et al. | Puerarin reduces ischemia/reperfusion-induced myocardial injury in diabetic rats via upregulation of vascular endothelial growth factor A/angiotensin-1 and suppression of apoptosis. | 2018 | Mol Med Rep | pmid:29568939 |
| Wang T et al. | Puerarin promotes MIN6 cell survival by reducing cellular reactive oxygen species. | 2018 | Mol Med Rep | pmid:29568901 |
| Wu JY et al. | A microemulsion of puerarin-phospholipid complex for improving bioavailability: preparation, in vitro and in vivo evaluations. | 2018 | Drug Dev Ind Pharm | pmid:29513046 |
| Ling C et al. | Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. | 2018 | Molecules | pmid:29498696 |
| Liu X et al. | Puerarin Inhibits Proliferation and Induces Apoptosis by Upregulation of miR-16 in Bladder Cancer Cell Line T24. | 2018 | Oncol. Res. | pmid:29422113 |
| Wang HQ et al. | Puerarin Up-regulates Methyl-CpG Binding Protein 2 Phosphorylation in Hippocampus of Vascular Dementia Rats. | 2018 | Chin J Integr Med | pmid:29327124 |
| Zhao Q et al. | Effects of glycyrrhizin on the pharmacokinetics of puerarin in rats. | 2018 | Xenobiotica | pmid:29099639 |
| Liu B et al. | Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29427658 |
| Kong H et al. | Effect of Puerarin on the Pharmacokinetics of Baicalin in Gegen Qinlian Decoction () in Mice. | 2018 | Chin J Integr Med | pmid:25908218 |
| Wang C et al. | Mechanism of aquaporin 4 (AQP 4) up-regulation in rat cerebral edema under hypobaric hypoxia and the preventative effect of puerarin. | 2018 | Life Sci. | pmid:29054452 |
| Slámová K et al. | "Sweet Flavonoids": Glycosidase-Catalyzed Modifications. | 2018 | Int J Mol Sci | pmid:30037103 |
| Liu Y et al. | Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells. | 2017 | Int. J. Biol. Sci. | pmid:28367097 |
| Ma X et al. | Puerarin attenuates cisplatin-induced rat nephrotoxicity: The involvement of TLR4/NF-κB signaling pathway. | 2017 | PLoS ONE | pmid:28182789 |
| Zheng QH et al. | Efficacy and safety of puerarin injection in curing acute ischemic stroke: A meta-analysis of randomized controlled trials. | 2017 | Medicine (Baltimore) | pmid:28072733 |
| Wu L et al. | Protective Effects of Puerarin against Aβ 1-42-Induced Learning and Memory Impairments in Mice. | 2017 | Planta Med. | pmid:27420352 |
| KopeÄná-Zapletalová M et al. | Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities. | 2017 | Xenobiotica | pmid:27312150 |
| Deng HF et al. | Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K/Akt/eNOS pathway and inhibiting activation of ERK1/2 and NF-κB. | 2017 | Life Sci. | pmid:29037842 |
| Tan C et al. | Puerarin Improves Vascular Insulin Resistance and Cardiovascular Remodeling in Salt-Sensitive Hypertension. | 2017 | Am. J. Chin. Med. | pmid:28830209 |
| Zhang WG et al. | Puerarin Induces Hepatocellular Carcinoma Cell Apoptosis Modulated by MAPK Signaling Pathways in a Dose-dependent Manner. | 2017 | Anticancer Res. | pmid:28739736 |
| Wang K et al. | Puerarin inhibits amyloid β-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses. | 2017 | Exp. Cell Res. | pmid:28583762 |
| Cheng HH et al. | Effects of puerarin on intracellular Ca and cell viability of MDCK renal tubular cells. | 2017 | Environ. Toxicol. Pharmacol. | pmid:28384516 |
| Zhou X et al. | Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro. | 2017 | Ren Fail | pmid:28335679 |
| Wang X et al. | Molecular characterization of the C-glucosylation for puerarin biosynthesis in Pueraria lobata. | 2017 | Plant J. | pmid:28207970 |