| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hsu FL et al. | Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. | 2003 | J. Nat. Prod. | pmid:12828463 |
| Shi HP and Kintzios S | Genetic transformation of Pueraria phaseoloides with Agrobacterium rhizogenes and puerarin production in hairy roots. | 2003 | Plant Cell Rep. | pmid:12836005 |
| Jin M et al. | [Clinical study on Tianbaokang injection against oxidative injury of vascular endothelial function in ischemic apoplexy]. | 2003 | Zhong Yao Cai | pmid:12795227 |
| Shi RL and Zhang JJ | [Protective effect of puerarin on vascular endothelial cell apoptosis induced by chemical hypoxia in vitro]. | 2003 | Yao Xue Xue Bao | pmid:12778743 |
| Li X et al. | Experimental study on the protective effect of puerarin to Parkinson disease. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:12973933 |
| Pan HP et al. | [Experimental study of puerarin injection on the hemorheology in acute blood-stasis model rats]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617506 |
| Bae HS et al. | Hepatoprotective activity of reduohanxiao-tang (yuldahanso-tang) is related to the inhibition of beta-glucuronidase. | 2003 | Am. J. Chin. Med. | pmid:12723760 |
| Jin WS et al. | [Determination of puerarin, daidzin and daidzein in root of Pueraria lobata of different origin by HPLC]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015267 |
| Overstreet DH et al. | NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. | 2003 | Pharmacol. Biochem. Behav. | pmid:12895679 |
| Li B and Yu S | [Effect of puerarin on the bone metabolism in vitro]. | 2003 | Beijing Da Xue Xue Bao | pmid:12920814 |
| Jiang B et al. | Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarin. | 2003 | Cell Biol. Int. | pmid:14642535 |
| Zhang GQ et al. | Puerarin blocks Na+ current in rat ventricular myocytes. | 2003 | Acta Pharmacol. Sin. | pmid:14653946 |
| Matkowski A et al. | Flavonoids of Pueraria lobata: chromatographic analysis of leaves and roots of cultivated plants. | 2003 | Pharmazie | pmid:14531473 |
| Shi HP et al. | [Culture of hairy roots in Pueraria phaseoloides and its puerarin production]. | 2003 | Shi Yan Sheng Wu Xue Bao | pmid:14724930 |
| Xie RQ et al. | [Myocardial protection and mechanism of Puerarin Injection on patients of coronary heart disease with ischemia/reperfusion]. | 2003 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:14714357 |
| Rezvani AH et al. | Plant derivatives in the treatment of alcohol dependency. | 2003 | Pharmacol. Biochem. Behav. | pmid:12895677 |
| Prasain JK et al. | Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. | 2003 | J. Agric. Food Chem. | pmid:12848487 |
| Overstreet DH et al. | Herbal remedies for alcoholism: promises and possible pitfalls. | 2003 | Alcohol. Clin. Exp. Res. | pmid:12605067 |
| Qi BL and Qi BM | [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12776591 |
| Wei GL et al. | Endotoxin removal in some medicines and human serum albumin solution by affinity membranes. | 2002 | Se Pu | pmid:12541963 |
| Shi WG et al. | [Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12585165 |
| Hsu HH et al. | Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. | 2002 | Planta Med. | pmid:12451490 |
| Liu JM et al. | [Therapeutic effect of puerarin therapy on sudden deafness]. | 2002 | Di Yi Jun Yi Da Xue Xue Bao | pmid:12433647 |
| Chen B et al. | [The rapid analysis of functional components of P. Lobata by near infrared spectrum]. | 2002 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12914179 |
| Yamaki K et al. | Effects of naturally occurring isoflavones on prostaglandin E2 production. | 2002 | Planta Med. | pmid:11859455 |
| Miao WN et al. | [Effect of Puerarin on K+ channel of isolated ventricular myocyte in guinea pig]. | 2002 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21179804 |
| Lee JS et al. | The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells. | 2002 | BMC Complement Altern Med | pmid:12485466 |
| Cervellati R et al. | Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. | 2002 | J. Agric. Food Chem. | pmid:12475261 |
| Xu XH and Zhao TQ | Effects of puerarin on D-galactose-induced memory deficits in mice. | 2002 | Acta Pharmacol. Sin. | pmid:12100749 |
| Xu XH and Zhang ZG | [Effect of puerarin on learning-memory behavior and synaptic structure of hippocampus in the aging mice induced by D-galactose]. | 2002 | Yao Xue Xue Bao | pmid:12579889 |
| Benlhabib E et al. | Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations. | 2002 | J Med Food | pmid:12495583 |
| Lee DS et al. | Fecal metabolic activities of herbal components to bioactive compounds. | 2002 | Arch. Pharm. Res. | pmid:12009030 |
| Keyler DE et al. | Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028. | 2002 | J Altern Complement Med | pmid:12006125 |
| Yu BS et al. | RP-HPLC determination of puerarin in Chinese traditional medicinal preparations containing pueraria. | 2002 | J Pharm Biomed Anal | pmid:12367710 |
| Hsieh MT et al. | Effects of puerarin on scopolamine-, mecamylamine-, p-chloroamphetamine- and dizocilpine-induced inhibitory avoidance performance impairment in rats. | 2002 | Planta Med. | pmid:12391553 |
| Choo MK et al. | Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora. | 2002 | Biol. Pharm. Bull. | pmid:12392089 |
| Zhu ZT et al. | [Inhibitive effect of puerarin on increased NO production by neonatal cardiomyocytes during hypoxia/reoxygenation injury]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776339 |
| Huang YF et al. | [Determination of puerarin in xinmaitong oral liquid by HPLC]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776346 |
| Tian J et al. | [Determination of puerarin in three traditional Chinese patent medicines by high performance liquid chromatography]. | 2001 | Se Pu | pmid:12545446 |
| Wu P et al. | [Study on effect of Puerarin on nitric oxide system in rats' tissue and its mechanism]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577337 |
| Luo ZR and Zheng B | [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577374 |
| Peng XY et al. | [Study on the differentiation and apoptosis of HL-60 cell line induced by Puerarin]. | 2001 | Hunan Yi Ke Da Xue Xue Bao | pmid:12536642 |
| Vera JC et al. | Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. | 2001 | Biochemistry | pmid:11170395 |
| Dong LP et al. | [The protective effect of puerarin on cultured rat cerebral cortical astrocytes]. | 2001 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171401 |
| Chen G et al. | Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection. | 2001 | J Chromatogr A | pmid:11510548 |
| Zhang GQ et al. | Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. | 2001 | Acta Pharmacol. Sin. | pmid:11742573 |
| Ma YS et al. | [Studies permeation of puerarin and its phospholipid complex through mouse skin in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512448 |
| Liu Q et al. | Restrictive effect of puerarin on myocardial infarct area in dogs and its possible mechanism. | 2000 | J. Tongji Med. Univ. | pmid:12845754 |
| Guerra MC et al. | Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. | 2000 | Life Sci. | pmid:11133012 |
| Ren P et al. | [Observation on efficacy of puerarin in treating diabetic retinopathy]. | 2000 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11789184 |