| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang C and Song Z | In vitro monitoring of nanogram levels of puerarin in human urine using flow injection chemiluminescence. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15261255 |
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| Ge B et al. | Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin. | 2017 | Biopharm Drug Dispos | pmid:27925234 |
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| Qu H et al. | Rapid lateral-flow immunoassay for the quantum dot-based detection of puerarin. | 2016 | Biosens Bioelectron | pmid:26991602 |
| Kintzios S et al. | Scale-up production of puerarin from hairy roots of Pueraria phaseoloides in an airlift bioreactor. | 2004 | Biotechnol. Lett. | pmid:15218379 |
| Efferth T et al. | Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells. | Blood Cells Mol. Dis. | pmid:12064912 | |
| Chang BY et al. | Protective activity of kudzu (Pueraria thunbergiana) vine on chemically-induced hepatotoxicity: in vitro and in vivo studies. | 2016 | BMC Complement Altern Med | pmid:26825303 |
| Lee JS et al. | The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells. | 2002 | BMC Complement Altern Med | pmid:12485466 |
| Wan Q et al. | Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway. | 2018 | BMC Complement Altern Med | pmid:29728095 |
| Wang MS et al. | Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. | 2010 | BMC Neurosci | pmid:20433710 |
| Li L et al. | Puerarin suppression of Aβ-induced primary cortical neuron death is largely dependent on ERβ. | 2017 | Brain Res. | pmid:27923632 |
| Li R et al. | Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats. | 2013 | Brain Res. | pmid:23603411 |
| Li R et al. | Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway. | 2013 | Brain Res. | pmid:23747813 |
| Xing G et al. | Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. | 2011 | Brain Res. Bull. | pmid:21473901 |
| Xu C et al. | Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat. | 2009 | Brain Res. Bull. | pmid:19744545 |
| Xu C et al. | Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons. | 2012 | Brain Res. Bull. | pmid:22044944 |
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| Liu S et al. | Puerarin attenuates severe burn-induced acute myocardial injury in rats. | 2015 | Burns | pmid:26514700 |
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| Tang L et al. | The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. | 2014 | Cell Biochem. Funct. | pmid:24496955 |
| Jiang B et al. | Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarin. | 2003 | Cell Biol. Int. | pmid:14642535 |
| Zhang HY et al. | Puerarin protects PC12 cells against beta-amyloid-induced cell injury. | 2008 | Cell Biol. Int. | pmid:18675923 |
| Zhang Q et al. | Puerarin protects differentiated PC12 cells from Hâ‚‚Oâ‚‚-induced apoptosis through the PI3K/Akt signalling pathway. | 2012 | Cell Biol. Int. | pmid:22126839 |
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| Yin M et al. | Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway. | 2015 | Cell. Physiol. Biochem. | pmid:26330232 |
| Wang L et al. | Puerarin facilitates T-tubule development of murine embryonic stem cell-derived cardiomyocytes. | 2014 | Cell. Physiol. Biochem. | pmid:25059232 |
| Cheng Y et al. | Effects of puerarin on cardiac differentiation and ventricular specialization of murine embryonic stem cells. | 2013 | Cell. Physiol. Biochem. | pmid:24080853 |
| Wang L et al. | Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a. | 2017 | Cell. Physiol. Biochem. | pmid:29179218 |
| Song XB et al. | Puerarin protects against cadmium-induced proximal tubular cell apoptosis by restoring mitochondrial function. | 2016 | Chem. Biol. Interact. | pmid:27717697 |
| Liu CM et al. | Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. | 2016 | Chem. Biol. Interact. | pmid:26607348 |
| Hou SZ et al. | Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. | 2011 | Chem. Biol. Interact. | pmid:21453687 |
| Qi H et al. | Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use. | 2006 | Chem. Pharm. Bull. | pmid:17077546 |
| Yu Z et al. | Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI). | 2006 | Chem. Pharm. Bull. | pmid:16595973 |
| Nakamura K et al. | The C-glucosyl bond of puerarin was cleaved hydrolytically by a human intestinal bacterium strain PUE to yield its aglycone daidzein and an intact glucose. | 2011 | Chem. Pharm. Bull. | pmid:21212542 |
| Yue PF et al. | Development and optimization of intravenous puerarin emulsions formation by a novel complex-phase inversion-homogenization technology. | 2007 | Chem. Pharm. Bull. | pmid:17978512 |
| Quan DQ et al. | Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin. | 2007 | Chem. Pharm. Bull. | pmid:17473473 |
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| Wu HQ et al. | Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats. | 2009 | Chin J Integr Med | pmid:19271171 |
| Liu Y et al. | Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor κB pathways. | 2014 | Chin J Integr Med | pmid:24122632 |
| Zhang MY et al. | In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. | 2012 | Chin J Integr Med | pmid:22457138 |
| Pang W et al. | Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils. | 2012 | Chin J Integr Med | pmid:22457139 |
| Zhao Y and Zhou Y | Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. | 2012 | Chin J Integr Med | pmid:22457141 |
| Li SW et al. | Comparison on Anticoagulation and Antiplatelet Aggregation Effects of Puerarin with Heparin Sodium and Tirofiban Hydrochloride: An In Vitro Study. | 2018 | Chin J Integr Med | pmid:29067595 |
| Wang HQ et al. | Puerarin Up-regulates Methyl-CpG Binding Protein 2 Phosphorylation in Hippocampus of Vascular Dementia Rats. | 2018 | Chin J Integr Med | pmid:29327124 |
| Kong H et al. | Effect of Puerarin on the Pharmacokinetics of Baicalin in Gegen Qinlian Decoction () in Mice. | 2018 | Chin J Integr Med | pmid:25908218 |
| Yuan SY et al. | Puerarin prevents bone loss in ovariectomized mice and inhibits osteoclast formation in vitro. | 2016 | Chin J Nat Med | pmid:27114313 |
| Liu AC et al. | Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats. | 2015 | Chin J Nat Med | pmid:25908622 |
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| Chen G et al. | Puerarin attenuates angiotensin II-induced cardiac fibroblast proliferation via the promotion of catalase activity and the inhibition of hydrogen peroxide-dependent Rac-1 activation. | 2018 | Chin J Nat Med | pmid:29425589 |
| Liu AC et al. | LC-MS/MS method for the determination of a new puerarin derivative and its application in pharmacokinetic studies in rats. | 2013 | Chin J Nat Med | pmid:24359785 |
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