| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li R et al. | Puerarin exerts the protective effect against chemical induced dysmetabolism in rats. | 2016 | Gene | pmid:27677221 |
| Loutchanwoot P et al. | Evaluation of in vivo estrogenic potency of natural estrogen-active chemical, puerarin, on pituitary function in gonadectomized female rats. | 2016 | Life Sci. | pmid:27615593 |
| Tanaka T et al. | Anti-Hyperglycemic Effect of a Kudzu (Pueraria lobata) Vine Extract in Ovariectomized Mice. | 2016 | J. Nutr. Sci. Vitaminol. | pmid:27928122 |
| Zhang Y et al. | Puerarin Prevents LPS-Induced Osteoclast Formation and Bone Loss via Inhibition of Akt Activation. | 2016 | Biol. Pharm. Bull. | pmid:27904045 |
| Liao ZG et al. | Improvement of Transmembrane Transport Mechanism Study of Imperatorin on P-Glycoprotein-Mediated Drug Transport. | 2016 | Molecules | pmid:27886150 |
| Ji Y et al. | Anticerebral Ischemia-Reperfusion Injury Activity of Synthesized Puerarin Derivatives. | 2016 | Biomed Res Int | pmid:27807543 |
| Zhang D et al. | The Neuroprotective Effect of Puerarin in Acute Spinal Cord Injury Rats. | 2016 | Cell. Physiol. Biochem. | pmid:27576607 |
| Zhang L et al. | Puerarin transport across a Calu-3 cell monolayer - an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol. | 2016 | Drug Des Devel Ther | pmid:27468226 |
| Wang K et al. | Neuroprotective Effect of Puerarin on Glutamate-Induced Cytotoxicity in Differentiated Y-79 Cells via Inhibition of ROS Generation and Ca(2+) Influx. | 2016 | Int J Mol Sci | pmid:27409614 |
| Wu H et al. | Puerarin Exerts an Antiinflammatory Effect by Inhibiting NF-kB and MAPK Activation in Staphylococcus aureus-Induced Mastitis. | 2016 | Phytother Res | pmid:27335240 |
| Chen J et al. | Puerarin affects bone biomarkers in the serum of rats with intrauterine growth restriction. | 2016 | J Tradit Chin Med | pmid:27400476 |
| Wang S et al. | Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition. | 2016 | Int. Immunopharmacol. | pmid:27318789 |
| Su B et al. | Relevance of the Pharmacokinetic and Pharmacodynamic Profiles of Puerariae lobatae Radix to Aggregation of Multi-Component Molecules in Aqueous Decoctions. | 2016 | Molecules | pmid:27367654 |
| Xu X et al. | Puerarin, isolated from Pueraria lobata (Willd.), protects against diabetic nephropathy by attenuating oxidative stress. | 2016 | Gene | pmid:27317894 |
| Zhang X et al. | Puerarin Attenuates Cardiac Hypertrophy Partly Through Increasing Mir-15b/195 Expression and Suppressing Non-Canonical Transforming Growth Factor Beta (Tgfβ) Signal Pathway. | 2016 | Med. Sci. Monit. | pmid:27145790 |
| Xiong N et al. | hVMAT2: A Target of Individualized Medication for Parkinson's Disease. | 2016 | Neurotherapeutics | pmid:27137201 |
| Wang C et al. | Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling. | 2016 | Mol Med Rep | pmid:27278131 |
| Cheng Y et al. | Protective Effect of Puerarin Against Oxidative Stress Injury of Neural Cells and Related Mechanisms. | 2016 | Med. Sci. Monit. | pmid:27074962 |
| Liu G et al. | Recent Advances in Methods of Puerarin Biotransformation. | 2016 | Mini Rev Med Chem | pmid:27145856 |
| Saraswat G et al. | Molecular cues to the anti-implantation effect of nano-puerarin in rats. | 2016 | Reproduction | pmid:27026713 |
| Wang Q et al. | WITHDRAWN: Puerarin injection for unstable angina pectoris. | 2016 | Cochrane Database Syst Rev | pmid:27136749 |
| Xue Q et al. | Lyophilized Powder of Catalpol and Puerarin Protects Neurovascular Unit from Stroke. | 2016 | Int. J. Biol. Sci. | pmid:27019622 |
| Wang ZK et al. | Alleviation of Lead-Induced Apoptosis by Puerarin via Inhibiting Mitochondrial Permeability Transition Pore Opening in Primary Cultures of Rat Proximal Tubular Cells. | 2016 | Biol Trace Elem Res | pmid:27116952 |
| Ma Y et al. | Puerarin Attenuates Anoxia/Reoxygenation Injury Through Enhancing Bcl-2 Associated Athanogene 3 Expression, a Modulator of Apoptosis and Autophagy. | 2016 | Med. Sci. Monit. | pmid:27011313 |
| Luo X et al. | Puerarin Exerts a Delayed Inhibitory Effect on the Proliferation of Cardiomyocytes Derived from Murine ES Cells via Slowing Progression through G2/M Phase. | 2016 | Cell. Physiol. Biochem. | pmid:27008508 |
| Hu Y et al. | Inhibitory effect of puerarin on vascular smooth muscle cells proliferation induced by oxidised low-density lipoprotein via suppressing ERK 1/2 phosphorylation and PCNA expression. | 2016 | Pharmazie | pmid:27004373 |
| Jiang QD and Li XP | Effect of puerarin on the expression of NMU, NPY, and POMC genes in the hypothalamus. | 2016 | Genet. Mol. Res. | pmid:26985919 |
| Yuan SY et al. | Puerarin prevents bone loss in ovariectomized mice and inhibits osteoclast formation in vitro. | 2016 | Chin J Nat Med | pmid:27114313 |
| Qu H et al. | Rapid lateral-flow immunoassay for the quantum dot-based detection of puerarin. | 2016 | Biosens Bioelectron | pmid:26991602 |
| Su HF et al. | Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms. | 2016 | Acta Pharmacol. Sin. | pmid:26972494 |
| Liu B et al. | Puerarin for ischaemic stroke. | 2016 | Cochrane Database Syst Rev | pmid:26891451 |
| Xu X et al. | Puerarin reduces apoptosis in rat hippocampal neurons culturea in high glucose medium by modulating the p38 mitogen activated protein kinase and c-Jun N-terminal kinase signaling pathways. | 2016 | J Tradit Chin Med | pmid:26946623 |
| Hong XP et al. | Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. | 2016 | J. Alzheimers Dis. | pmid:26890737 |
| Li W et al. | Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats. | 2016 | J Diabetes Res | pmid:26881260 |
| Suthon S et al. | Anti-osteoporotic effects of Pueraria candollei var. mirifica on bone mineral density and histomorphometry in estrogen-deficient rats. | 2016 | J Nat Med | pmid:26815435 |
| Chang BY et al. | Protective activity of kudzu (Pueraria thunbergiana) vine on chemically-induced hepatotoxicity: in vitro and in vivo studies. | 2016 | BMC Complement Altern Med | pmid:26825303 |
| Qiao L et al. | A HPLC-MS/MS method for determination of 6'''-feruloylspinosin in rat plasma and tissues: Pharmacokinetics and tissue distribution study. | 2016 | J Pharm Biomed Anal | pmid:26780157 |
| Zhao YZ et al. | Using PG-Liposome-Based System to Enhance Puerarin Liver-Targeted Therapy for Alcohol-Induced Liver Disease. | 2016 | AAPS PharmSciTech | pmid:26753818 |
| Huang FJ and Chan WH | Apoptotic effects on maturation of mouse oocytes, fertilization and fetal development by puerarin. | 2016 | Drug Chem Toxicol | pmid:26712108 |
| Cheng G et al. | Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique. | 2016 | AAPS PharmSciTech | pmid:26694058 |
| Liu X et al. | Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. | 2016 | Metab Brain Dis | pmid:26686502 |
| Liu CM et al. | Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. | 2016 | Chem. Biol. Interact. | pmid:26607348 |
| Zhang H et al. | Puerarin Inhibits oxLDL-Induced Macrophage Activation and Foam Cell Formation in Human THP1 Macrophage. | 2015 | Biomed Res Int | pmid:26576421 |
| Wu S et al. | Study of the Biotransformation of Tongmai Formula by Human Intestinal Flora and Its Intestinal Permeability across the Caco-2 Cell Monolayer. | 2015 | Molecules | pmid:26501241 |
| Yin M et al. | Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway. | 2015 | Cell. Physiol. Biochem. | pmid:26330232 |
| Wang D et al. | Automated On-Line Microdialysis Sampling Coupled with HPLC for Synchronous Determination of Puerarin in Subcutaneous Tissue and Plasma Following Topical Administration. | 2015 | Clin. Lab. | pmid:26554250 |
| Wang D et al. | Evaluation of kudzu root extract-induced hepatotoxicity. | 2015 | J Ethnopharmacol | pmid:26545459 |
| Liu S et al. | Puerarin attenuates severe burn-induced acute myocardial injury in rats. | 2015 | Burns | pmid:26514700 |
| Zhao SS et al. | Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZ-induced SAD mice. | 2015 | Neurotoxicology | pmid:26511841 |
| Bao L et al. | The anti-atherosclerotic effects of puerarin on induced-atherosclerosis in rabbits. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:24510110 |