| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fu C et al. | [The study of ethanol-water used as reversed-phase high performance liquid chromatographic mobile phase]. | 1999 | Se Pu | pmid:12552885 |
| Okamura N et al. | Simultaneous high-performance liquid chromatographic determination of puerarin, daidzin, paeoniflorin, liquiritin, cinnamic acid, cinnamaldehyde and glycyrrhizin in Kampo medicines. | 1999 | J Pharm Biomed Anal | pmid:10704126 |
| Qian Y et al. | Blocking effect of puerarin on calcium channel in isolated guinea pig ventricular myocytes. | 1999 | Chin. Med. J. | pmid:11717945 |
| Meng P et al. | [Clinical observation of the treatment of infantile viral myocarditis with puerarin]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783152 |
| Chen J et al. | [Effect of puerarin on fibrinolytic activity and lipid peroxide in patients with coronary heart disease]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783153 |
| Liu Q et al. | [Effect of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205891 |
| Wang YJ et al. | [Determination of beberine hydrochloride and puerarin in tangwei capsules by RP-HPLC of gradient elution method]. | 2000 | Se Pu | pmid:12541715 |
| Ma YS et al. | [Studies permeation of puerarin and its phospholipid complex through mouse skin in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512448 |
| Liu Q et al. | Restrictive effect of puerarin on myocardial infarct area in dogs and its possible mechanism. | 2000 | J. Tongji Med. Univ. | pmid:12845754 |
| Guerra MC et al. | Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. | 2000 | Life Sci. | pmid:11133012 |
| Ren P et al. | [Observation on efficacy of puerarin in treating diabetic retinopathy]. | 2000 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11789184 |
| Jiang B et al. | [Stable life prediction for a complex injection of Chinese materia medica by initial average rate stability test]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12212078 |
| Duan S et al. | [Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure]. | 2000 | Hunan Yi Ke Da Xue Xue Bao | pmid:12212215 |
| Tian J et al. | [Determination of puerarin in three traditional Chinese patent medicines by high performance liquid chromatography]. | 2001 | Se Pu | pmid:12545446 |
| Wu P et al. | [Study on effect of Puerarin on nitric oxide system in rats' tissue and its mechanism]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577337 |
| Luo ZR and Zheng B | [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577374 |
| Peng XY et al. | [Study on the differentiation and apoptosis of HL-60 cell line induced by Puerarin]. | 2001 | Hunan Yi Ke Da Xue Xue Bao | pmid:12536642 |
| Dong LP et al. | [The protective effect of puerarin on cultured rat cerebral cortical astrocytes]. | 2001 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171401 |
| Chen G et al. | Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection. | 2001 | J Chromatogr A | pmid:11510548 |
| Zhang GQ et al. | Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. | 2001 | Acta Pharmacol. Sin. | pmid:11742573 |