| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yin M et al. | Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway. | 2015 | Cell. Physiol. Biochem. | pmid:26330232 |
| Pan X et al. | Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats. | 2015 | Med. Sci. Monit. | pmid:26201474 |
| Zhang J et al. | Puerarin attenuates cognitive dysfunction and oxidative stress in vascular dementia rats induced by chronic ischemia. | 2015 | Int J Clin Exp Pathol | pmid:26191159 |
| Wang D et al. | Automated On-Line Microdialysis Sampling Coupled with HPLC for Synchronous Determination of Puerarin in Subcutaneous Tissue and Plasma Following Topical Administration. | 2015 | Clin. Lab. | pmid:26554250 |
| Gang C et al. | Puerarin Suppresses Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting NADPH Oxidase Activation and Oxidative Stress-Triggered AP-1 Signaling Pathways. | 2015 | J Pharm Pharm Sci | pmid:26158288 |
| Wang D et al. | Evaluation of kudzu root extract-induced hepatotoxicity. | 2015 | J Ethnopharmacol | pmid:26545459 |
| Yu D et al. | Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways. | 2015 | Int. J. Mol. Med. | pmid:26101183 |
| Liu S et al. | Puerarin attenuates severe burn-induced acute myocardial injury in rats. | 2015 | Burns | pmid:26514700 |
| Cheng W et al. | Puerarin improves cardiac function through regulation of energy metabolism in Streptozotocin-Nicotinamide induced diabetic mice after myocardial infarction. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26079885 |
| Zhao SS et al. | Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZ-induced SAD mice. | 2015 | Neurotoxicology | pmid:26511841 |
| Wenjun H et al. | The Protective Effect of Puerarin on Myocardial Infarction Reperfusion Injury (MIRI): A Meta-Analysis of Randomized Studies in Rat Models. | 2015 | Med. Sci. Monit. | pmid:26067875 |
| Cui SQ et al. | Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. | 2015 | Braz. J. Med. Biol. Res. | pmid:25831201 |
| Zheng G et al. | Effects of puerarin on lipid accumulation and metabolism in high-fat diet-fed mice. | 2015 | PLoS ONE | pmid:25822741 |
| Yi Y et al. | The construction of puerarin nanocrystals and its pharmacokinetic and in vivo-in vitro correlation (IVIVC) studies on beagle dog. | 2015 | Colloids Surf B Biointerfaces | pmid:26099971 |
| Guo XF et al. | Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma. | 2015 | Mol Med Rep | pmid:25434307 |
| Sun D et al. | Simultaneous determination of acetylpuerarin and puerarin in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study following intravenous and oral administration. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26021848 |
| Liu AC et al. | Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats. | 2015 | Chin J Nat Med | pmid:25908622 |
| Lv H et al. | Puerarin enhances proliferation and osteoblastic differentiation of human bone marrow stromal cells via a nitric oxide/cyclic guanosine monophosphate signaling pathway. | 2015 | Mol Med Rep | pmid:25892538 |
| Zou ZJ et al. | Intervention effects of puerarin on blood stasis in rats revealed by a (1)H NMR-based metabonomic approach. | 2015 | Phytomedicine | pmid:25837270 |
| Gray SL et al. | Impact of kudzu and puerarin on sperm function. | 2015 | Reprod. Toxicol. | pmid:25828059 |
| Han P et al. | Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells. | 2015 | Life Sci. | pmid:25817234 |
| Wang Z et al. | Protective effects of edaravone combined puerarin on inhalation lung injury induced by black gunpowder smog. | 2015 | Int. Immunopharmacol. | pmid:25754765 |
| Zhang Y et al. | The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression. | 2015 | Ren Fail | pmid:25707518 |
| Bao L et al. | The anti-atherosclerotic effects of puerarin on induced-atherosclerosis in rabbits. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:24510110 |
| Yang X et al. | Puerarin decreases bone loss and collagen destruction in rats with ligature-induced periodontitis. | 2015 | J. Periodont. Res. | pmid:25645818 |
| Qu J et al. | Puerarin alleviates noise-induced hearing loss via affecting PKCγ and GABAB receptor expression. | 2015 | J. Neurol. Sci. | pmid:25592416 |
| Guo HD et al. | Large scale purification of puerarin from Puerariae Lobatae Radix through resins adsorption and acid hydrolysis. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25553536 |
| Wang X et al. | De novo transcriptome sequencing in Pueraria lobata to identify putative genes involved in isoflavones biosynthesis. | 2015 | Plant Cell Rep. | pmid:25547742 |
| Wang J et al. | Puerarin attenuates airway inflammation by regulation of eotaxin-3. | 2015 | Immunol. Lett. | pmid:25530546 |
| Liang XL et al. | Mechanisms of improvement of intestinal transport of baicalin and puerarin by extracts of Radix Angelicae Dahuricae. | 2015 | Phytother Res | pmid:25312586 |
| Zhao J et al. | Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK1/2 and PI3K/Akt signaling pathways in the neurite extension process. | 2015 | CNS Neurosci Ther | pmid:25310912 |
| Wang P et al. | Rapid determination of major bioactive isoflavonoid compounds during the extraction process of kudzu (Pueraria lobata) by near-infrared transmission spectroscopy. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25310261 |
| Tian F et al. | The neuroprotective mechanism of puerarin in the treatment of acute spinal ischemia-reperfusion injury is linked to cyclin-dependent kinase 5. | 2015 | Neurosci. Lett. | pmid:25301568 |
| Yang S et al. | Protective effects of puerarin against tetrabromobisphenol a-induced apoptosis and cardiac developmental toxicity in zebrafish embryo-larvae. | 2015 | Environ. Toxicol. | pmid:24596333 |
| Liao D et al. | N-trimethyl chitosan (TMC)-modified microemulsions for improved oral bioavailability of puerarin: preparation and evaluation. | 2015 | Drug Deliv | pmid:24467620 |
| Kang OH et al. | Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. | 2015 | Int. J. Mol. Med. | pmid:25605057 |
| Wu M et al. | Effects of delayed puerarin treatment in long-term neurological outcomes of focal ischemic stroke in rats. | 2014 Mar-Apr | Indian J Pharmacol | pmid:24741185 |
| Wang J et al. | Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer. | 2014 | Mol Med Rep | pmid:25189132 |
| Zhang WG et al. | Puerarin inhibits growth and induces apoptosis in SMMC-7721 hepatocellular carcinoma cells. | 2014 | Mol Med Rep | pmid:25175767 |
| Wang C et al. | Puerarin protects against β-amyloid-induced microglia apoptosis via a PI3K-dependent signaling pathway. | 2014 | Neurochem. Res. | pmid:25173404 |
| Xie N et al. | Puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures through antioxidant and anti-apoptotic mechanisms. | 2014 | Cell. Mol. Neurobiol. | pmid:25151533 |
| Maji AK et al. | Pueraria tuberosa: a review on its phytochemical and therapeutic potential. | 2014 | Nat. Prod. Res. | pmid:24980468 |
| Ma JQ et al. | Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway. | 2014 | Food Chem. Toxicol. | pmid:24975872 |
| Wang C et al. | The proliferation, differentiation, and mineralization effects of puerarin on osteoblasts in vitro. | 2014 | Chin J Nat Med | pmid:24969524 |
| Zhu G et al. | Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. | 2014 | Phytother Res | pmid:23512787 |
| Bao MH et al. | Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24708212 |
| Mahdy HM et al. | The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24593790 |
| Wang XC et al. | [Effect of chaperone-mediated autophagy in MPP(+) -induced SH-SY5Y cells and interventional effect of puerarin]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24754178 |
| Qu H et al. | Development of an enzyme-linked immunosorbent assay based on anti-puerarin monoclonal antibody and its applications. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24583873 |
| Liao ZG et al. | Transport properties of puerarin and effect of extract of Radix Angelicae dahuricae on puerarin intestinal absorption using in situ and in vitro models. | 2014 | Phytother Res | pmid:24756954 |