genistein 7-O-glucoside

genistein 7-O-glucoside is a lipid of Polyketides (PK) class. Genistein 7-o-glucoside is associated with abnormalities such as athymia, Heart Diseases, Thyroid Diseases, Plague and Brucella infections. The involved functions are known as Cell Proliferation, Binding (Molecular Function), Ingestion, topoisomerase activity and kinase activity. Genistein 7-o-glucoside often locates in Membrane, Gastrointestinal tract structure, Oral region, Body tissue and Blood. The associated genes with genistein 7-O-glucoside are GLUCOSIDASE, PPP1R1A gene, Homologous Gene, Genome and FUSE gene. The related lipids are Sterols, 1,2-oleoylphosphatidylcholine, Membrane Lipids and DOPE.

Cross Reference

Introduction

To understand associated biological information of genistein 7-O-glucoside, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with genistein 7-O-glucoside?

genistein 7-O-glucoside is suspected in athymia, Heart Diseases, Thyroid Diseases, Plague, Brucella infections, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with genistein 7-O-glucoside

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Weight Gain D015430 101 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Vitreoretinopathy, Proliferative D018630 4 associated lipids
Hot Flashes D019584 5 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Eye Injuries D005131 7 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with genistein 7-O-glucoside

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with genistein 7-O-glucoside?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with genistein 7-O-glucoside?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with genistein 7-O-glucoside?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with genistein 7-O-glucoside?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with genistein 7-O-glucoside?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with genistein 7-O-glucoside

Download all related citations
Per page 10 20 50 100 | Total 159
Authors Title Published Journal PubMed Link
Liang Y et al. A Comprehensive Screening and Identification of Genistin Metabolites in Rats Based on Multiple Metabolite Templates Combined with UHPLC-HRMS Analysis. 2018 Molecules pmid:30049985
Fusco FA et al. Biochemical characterization of a novel thermostable β-glucosidase from Dictyoglomus turgidum. 2018 Int. J. Biol. Macromol. pmid:29518444
Li X et al. An extremely thermostable maltogenic amylase from Staphylothermus marinus: Bacillus expression of the gene and its application in genistin glycosylation. 2018 Int. J. Biol. Macromol. pmid:28887188
Zhu Y et al. Synergistic Effect of Bioactive Anticarcinogens from Soybean on Anti-Proliferative Activity in MDA-MB-231 and MCF-7 Human Breast Cancer Cells In Vitro. 2018 Molecules pmid:29954123
Boonpawa R et al. In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans. 2017 Br. J. Pharmacol. pmid:28585232
Soukup ST et al. Influence of testosterone on phase II metabolism and availability of soy isoflavones in male Wistar rats. 2017 Arch. Toxicol. pmid:27743010
Kopečná-Zapletalová M et al. Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities. 2017 Xenobiotica pmid:27312150
Sordon S et al. Microbial Glycosylation of Daidzein, Genistein and Biochanin A: Two New Glucosides of Biochanin A. 2017 Molecules pmid:28054950
Chiang CM et al. Improving Free Radical Scavenging Activity of Soy Isoflavone Glycosides Daidzin and Genistin by 3'-Hydroxylation Using Recombinant Escherichia coli. 2016 Molecules pmid:27983702
Hicks KD et al. Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats. 2016 Horm Behav pmid:27373758
Yuk HJ et al. Ethylene Induced a High Accumulation of Dietary Isoflavones and Expression of Isoflavonoid Biosynthetic Genes in Soybean (Glycine max) Leaves. 2016 J. Agric. Food Chem. pmid:27626287
Zhang Y and Chang SK Isoflavone Profiles and Kinetic Changes during Ultra-High Temperature Processing of Soymilk. 2016 J. Food Sci. pmid:26814612
Liu CT et al. Enrichment of two isoflavone aglycones in black soymilk by Rhizopus oligosporus NTU 5 in a plastic composite support bioreactor. 2016 J. Sci. Food Agric. pmid:26676892
Persiani S et al. Evaluation of Levothyroxine Bioavailability after Oral Administration of a Fixed Combination of Soy Isoflavones in Post-menopausal Female Volunteers. 2016 Drug Res (Stuttg) pmid:26125285
Liu L et al. Rapid Screening and Identification of BSA Bound Ligands from Radix astragali Using BSA Immobilized Magnetic Nanoparticles Coupled with HPLC-MS. 2016 Molecules pmid:27827956
da Graça JP et al. The natural plant stress elicitor cis-jasmone causes cultivar-dependent reduction in growth of the stink bug, Euschistus heros and associated changes in flavonoid concentrations in soybean, Glycine max. 2016 Phytochemistry pmid:27659594
Qu H et al. Rapid, sensitive separation of the three main isoflavones in soybean using immunoaffinity chromatography. 2016 J Sep Sci pmid:26813984
Sakamoto S et al. Colloidal gold-based indirect competitive immunochromatographic assay for rapid detection of bioactive isoflavone glycosides daidzin and genistin in soy products. 2016 Food Chem pmid:26471543
Baú TR et al. Changes in soymilk during fermentation with kefir culture: oligosaccharides hydrolysis and isoflavone aglycone production. 2015 Int J Food Sci Nutr pmid:26460145
Hu Y et al. Application of Frontal Affinity Chromatography to Study the Biomolecular Interactions with Trypsin. 2015 J Chromatogr Sci pmid:25362198
Sakamoto S et al. Simultaneous determination of soy isoflavone glycosides, daidzin and genistin by monoclonal antibody-based highly sensitive indirect competitive enzyme-linked immunosorbent assay. 2015 Food Chem pmid:25236207
Hati S et al. β-Glucosidase activity and bioconversion of isoflavones during fermentation of soymilk. 2015 J. Sci. Food Agric. pmid:24838442
Andres S et al. Determination of the isoflavone composition and estrogenic activity of commercial dietary supplements based on soy or red clover. 2015 Food Funct pmid:26023053
Chulkov EG et al. Membrane dipole modifiers modulate single-length nystatin channels via reducing elastic stress in the vicinity of the lipid mouth of a pore. 2015 Biochim. Biophys. Acta pmid:25223717
Kubeš J et al. The production of isoflavonoids in Genista tinctoria L. cell suspension culture after abiotic stressors treatment. 2014 Nat. Prod. Res. pmid:25050873
Li YF et al. Metabolic studies of four soy isoflavones in rats by HPLC-HR-MS. 2014 J Asian Nat Prod Res pmid:24697158
Yerramsetty V et al. Malonylglucoside conjugates of isoflavones are much less bioavailable compared with unconjugated β-glucosidic forms in rats. 2014 J. Nutr. pmid:24647389
Li J et al. Molecular cloning and characterization of an isoflavone 7-O-glucosyltransferase from Pueraria lobata. 2014 Plant Cell Rep. pmid:24700248
Koirala N et al. Glycosylation and subsequent malonylation of isoflavonoids in E. coli: strain development, production and insights into future metabolic perspectives. 2014 J. Ind. Microbiol. Biotechnol. pmid:25189810
Silvan JM et al. Glycation is regulated by isoflavones. 2014 Food Funct pmid:25051420
Islam MA et al. Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models. 2014 Mol Nutr Food Res pmid:24668774
van der Velpen V et al. Isoflavone supplement composition and equol producer status affect gene expression in adipose tissue: a double-blind, randomized, placebo-controlled crossover trial in postmenopausal women. 2014 Am. J. Clin. Nutr. pmid:25332325
Du L et al. A β-glucosidase from Novosphingobium sp. GX9 with high catalytic efficiency toward isoflavonoid glycoside hydrolysis and (+)-catechin transglycosylation. 2014 Appl. Microbiol. Biotechnol. pmid:24682446
Oh HJ et al. Identification of daidzein as a ligand of retinoic acid receptor that suppresses expression of matrix metalloproteinase-9 in HaCaT cells. 2013 Mol. Cell. Endocrinol. pmid:23791815
Xiong YJ et al. The characteristics of genistin-induced inhibitory effects on intestinal motility. 2013 Arch. Pharm. Res. pmid:23435915
Li D et al. Characterization and application of an acidophilic and thermostable β-glucosidase from Thermofilum pendens. 2013 J. Biosci. Bioeng. pmid:23266119
Bontempo P et al. Genista sessilifolia DC. extracts induce apoptosis across a range of cancer cell lines. 2013 Cell Prolif. pmid:23510473
Park DJ et al. Characterization of a cold-active β-glucosidase from Paenibacillus xylanilyticus KJ-03 capable of hydrolyzing isoflavones daidzin and genistin. 2013 Protein J. pmid:24141566
Dong X et al. Apoptotic effects of cooked and in vitro digested soy on human prostate cancer cells. 2012 Food Chem pmid:22953905
Zou P et al. Comparative evaluation of the teratogenicity of genistein and genistin using rat whole embryo culture and limbud micromass culture methods. 2012 Food Chem. Toxicol. pmid:22617716
Yeom SJ et al. Hydrolysis of isoflavone glycosides by a thermostable β-glucosidase from Pyrococcus furiosus. 2012 J. Agric. Food Chem. pmid:22251001
Yuan B et al. Absorption and plasma disposition of genistin differ from those of genistein in healthy women. 2012 J. Agric. Food Chem. pmid:22256777
Yellepeddi VK et al. Comparative evaluation of small-molecule chemosensitizers in reversal of cisplatin resistance in ovarian cancer cells. 2012 Anticancer Res. pmid:22993302
Jin X et al. [Response surface method optimize of nano-silica solid dispersion technology assistant enzymatic hydrolysis preparation genistein]. 2012 Yao Xue Xue Bao pmid:22799038
Hamdy SM et al. Prevention of rat breast cancer by genistin and selenium. 2012 Toxicol Ind Health pmid:22089659
Kuo LC et al. A process for high-efficiency isoflavone deglycosylation using Bacillus subtilis natto NTU-18. 2012 Appl. Microbiol. Biotechnol. pmid:22350317
Park M et al. Modification of isoflavone profiles in a fermented soy food with almond powder. 2012 J. Food Sci. pmid:22182181
Iovine B et al. A comparative analysis of the photo-protective effects of soy isoflavones in their aglycone and glucoside forms. 2012 Int J Mol Sci pmid:23211668
Zhao C et al. Rapid simultaneous determination of major isoflavones of Pueraria lobata and discriminative analysis of its geographical origins by principal component analysis. 2011 Nov-Dec Phytochem Anal pmid:21495105
Theil C et al. The effects of different lignans and isoflavones, tested as aglycones and glycosides, on hormone receptor-positive and -negative breast carcinoma cells in vitro. 2011 Arch. Gynecol. Obstet. pmid:20821227
Ajdžanović V et al. The negative effect of soy extract on erythrocyte membrane fluidity: an electron paramagnetic resonance study. 2011 J. Membr. Biol. pmid:21132426
Jefferson WN and Williams CJ Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes. 2011 Reprod. Toxicol. pmid:20955782
Pandey BP et al. Screening of bacterial cytochrome P450s responsible for regiospecific hydroxylation of (iso)flavonoids. 2011 Enzyme Microb. Technol. pmid:22112954
Rijk JC et al. Bioassay based screening of steroid derivatives in animal feed and supplements. 2011 Anal. Chim. Acta pmid:21742131
Zheng ZP et al. Phenolic tyrosinase inhibitors from the stems of Cudrania cochinchinensis. 2011 Food Funct pmid:21779564
Liu Y et al. Depolarization induces NR2A tyrosine phosphorylation and neuronal apoptosis. 2011 Can J Neurol Sci pmid:22030427
Bolaños R et al. Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysis. 2010 May-Jun Menopause pmid:20464785
Park CU et al. Formation of succinyl genistin and succinyl daidzin by Bacillus species. 2010 Jan-Feb J. Food Sci. pmid:20492143
You J and Jiang D [Effect of genistin on proliferative vitreoretinopathy]. 2010 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:20693719
Rauter AP et al. Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. 2010 Phytother Res pmid:20309949
Hooshmand S et al. Combination of genistin and fructooligosaccharides prevents bone loss in ovarian hormone deficiency. 2010 J Med Food pmid:20132047
Yeo SK and Liong MT Angiotensin I-converting enzyme inhibitory activity and bioconversion of isoflavones by probiotics in soymilk supplemented with prebiotics. 2010 Int J Food Sci Nutr pmid:20085504
Wong RW and Rabie AB Effect of genistin on bone formation. 2010 Front Biosci (Elite Ed) pmid:20036920
Hsu A et al. Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. 2010 Exp. Biol. Med. (Maywood) pmid:20404023
Terigar BG et al. Continuous microwave-assisted isoflavone extraction system: design and performance evaluation. 2010 Bioresour. Technol. pmid:20018507
Reiter E et al. Comparison of hormonal activity of isoflavone-containing supplements used to treat menopausal complaints. 2009 Sep-Oct Menopause pmid:19430319
Yuan D et al. Inhibitory activity of isoflavones of Pueraria flowers on nitric oxide production from lipopolysaccharide-activated primary rat microglia. 2009 J Asian Nat Prod Res pmid:20183278
Jefferson WN et al. Oral exposure to genistin, the glycosylated form of genistein, during neonatal life adversely affects the female reproductive system. 2009 Environ. Health Perspect. pmid:20049207
Ballistreri G et al. Influence of ripeness and drying process on the polyphenols and tocopherols of Pistacia vera L. 2009 Molecules pmid:19924070
Muñoz Y et al. Equol is more active than soy isoflavone itself to compete for binding to thromboxane A(2) receptor in human platelets. 2009 Thromb. Res. pmid:18786699
Lee SW et al. Effects of riboflavin photosensitization on the changes of isoflavones in soymilk. 2008 J. Food Sci. pmid:18803701
Tategu M et al. Puma is a novel target of soy isoflavone genistein but is dispensable for genistein-induced cell fate determination. 2008 Mol Nutr Food Res pmid:18324703
Shih CH et al. Accumulation of isoflavone genistin in transgenic tomato plants overexpressing a soybean isoflavone synthase gene. 2008 J. Agric. Food Chem. pmid:18540614
Hooshmand S et al. The combination of genistin and ipriflavone prevents mammary tumorigenesis and modulates lipid profile. 2008 Clin Nutr pmid:18571816
Klejdus B et al. Ultrahigh-pressure liquid chromatography of isoflavones and phenolic acids on different stationary phases. 2008 J Chromatogr A pmid:18501366
Rekha CR and Vijayalakshmi G Biomolecules and nutritional quality of soymilk fermented with probiotic yeast and bacteria. 2008 Appl. Biochem. Biotechnol. pmid:18607548
Cherdshewasart W and Sriwatcharakul S Metabolic activation promotes estrogenic activity of the phytoestrogen-rich plant. 2008 Maturitas pmid:18313242
Cherdshewasart W et al. Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata. 2007 J Pharm Biomed Anal pmid:16930918
Nielsen IL and Williamson G Review of the factors affecting bioavailability of soy isoflavones in humans. 2007 Nutr Cancer pmid:17516857
Choi EJ et al. Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells. 2007 Life Sci. pmid:17291540
Kwon SH et al. Comparison of oral bioavailability of genistein and genistin in rats. 2007 Int J Pharm pmid:17280808
Bastián Y et al. In spermatozoa, Stat1 is activated during capacitation and the acrosomal reaction. 2007 Reproduction pmid:17709561
Cherdshewasart W and Sriwatcharakul S Major isoflavonoid contents of the 1-year-cultivated phytoestrogen-rich herb, Pueraria mirifica. 2007 Biosci. Biotechnol. Biochem. pmid:17928711
Kirakosyan A et al. Regulation of isoflavone production in hydroponically grown Pueraria montana (kudzu) by cork pieces, XAD-4, and methyl jasmonate. 2006 Plant Cell Rep. pmid:16841218
Kurejová M and Lacinová L Effect of protein tyrosine kinase inhibitors on the current through the Ca(V)3.1 channel. 2006 Arch. Biochem. Biophys. pmid:16386702
Zhao JH et al. Oral administration of soy-derived genistin suppresses lipopolysaccharide-induced acute liver inflammation but does not induce thymic atrophy in the rat. 2006 Life Sci. pmid:16257011
Yang X et al. [Preparation of soybean isoflavone glucosides by reversed-phase high performance liquid chromatography]. 2006 Se Pu pmid:17017161
Kuo LC et al. Hydrolysis of black soybean isoflavone glycosides by Bacillus subtilis natto. 2006 Appl. Microbiol. Biotechnol. pmid:16715232
Missan S et al. Tyrosine kinase and phosphatase regulation of slow delayed-rectifier K+ current in guinea-pig ventricular myocytes. 2006 J. Physiol. (Lond.) pmid:16581870
Süss C et al. Identification of genistein-inducible and type III-secreted proteins of Bradyrhizobium japonicum. 2006 J. Biotechnol. pmid:16707185
Steensma A et al. Bioavailability of genistein and its glycoside genistin as measured in the portal vein of freely moving unanesthetized rats. 2006 J. Agric. Food Chem. pmid:17032002
Walle T et al. Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans. 2005 J. Nutr. pmid:15623831
Chu Q et al. Simultaneous determination of phytoestrogens in different medicinal parts of Sophora japonica L. by capillary electrophoresis with electrochemical detection. 2005 Biomed. Chromatogr. pmid:15558700
Bian QQ et al. [Simultaneous determination of the four effective components in Huaijiao pill by HPLC]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16335821
Li XH et al. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. 2005 Acta Pharmacol. Sin. pmid:16115375
Uchiyama Y et al. Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin. 2005 Biochim. Biophys. Acta pmid:16099107
Browning AM et al. Flavonoid glycosides inhibit oral cancer cell proliferation--role of cellular uptake and hydrolysis to the aglycones. 2005 J. Pharm. Pharmacol. pmid:16102260
Yasuda S et al. Simultaneous determination of isoflavones and bisphenol A in rat serum by high-performance liquid chromatography coupled with coulometric array detection. 2004 Biosci. Biotechnol. Biochem. pmid:14745163
Andlauer W et al. Phloridzin improves absorption of genistin in isolated rat small intestine. 2004 Clin Nutr pmid:15380887
Polkowski K et al. Cytostatic and cytotoxic activity of synthetic genistein glycosides against human cancer cell lines. 2004 Cancer Lett. pmid:14670618