Isoangustone A

Isoangustone A is a lipid of Polyketides (PK) class. Isoangustone a is associated with abnormalities such as Hypertensive disease and Hypertensive Encephalopathy. The involved functions are known as Cell Proliferation, Phosphorylation, Cell Cycle, Cell Cycle Progression and Apoptosis.

Cross Reference

Introduction

To understand associated biological information of Isoangustone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isoangustone A?

Isoangustone A is suspected in Hypertensive disease, Hypertensive Encephalopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isoangustone A

MeSH term MeSH ID Detail
Mammary Neoplasms, Experimental D008325 67 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Melanoma D008545 69 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Isoangustone A

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isoangustone A?

There are no associated biomedical information in the current reference collection.

What functions are associated with Isoangustone A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Isoangustone A?

There are no associated biomedical information in the current reference collection.

What genes are associated with Isoangustone A?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Isoangustone A?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isoangustone A

Download all related citations
Total 8
Authors Title Published Journal PubMed Link
Huang W et al. Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions. 2014 Fitoterapia pmid:24486984
Lee E et al. CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth. 2013 Toxicol. Appl. Pharmacol. pmid:23707764
Song NR et al. Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. 2013 Cancer Prev Res (Phila) pmid:24104352
Seon MR et al. Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells. 2012 J. Nutr. Biochem. pmid:21429724
Li J et al. Isoangustone A suppresses mesangial fibrosis and inflammation in human renal mesangial cells. 2011 Exp. Biol. Med. (Maywood) pmid:21367880
Seon MR et al. Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway. 2010 Mol Nutr Food Res pmid:20229524
Lee YS et al. Rapid identification and preparative isolation of antioxidant components in licorice. 2010 J Sep Sci pmid:20112307
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