MeSH term | MeSH ID | Detail |
---|---|---|
Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
Prostatic Neoplasms | D011471 | 126 associated lipids |
Melanoma | D008545 | 69 associated lipids |
Isoangustone A is a lipid of Polyketides (PK) class. Isoangustone a is associated with abnormalities such as Hypertensive disease and Hypertensive Encephalopathy. The involved functions are known as Cell Proliferation, Phosphorylation, Cell Cycle, Cell Cycle Progression and Apoptosis.
To understand associated biological information of Isoangustone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isoangustone A is suspected in Hypertensive disease, Hypertensive Encephalopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Isoangustone A
MeSH term | MeSH ID | Detail |
---|---|---|
Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
Prostatic Neoplasms | D011471 | 126 associated lipids |
Melanoma | D008545 | 69 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Huang W et al. | Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions. | 2014 | Fitoterapia | pmid:24486984 |
Lee E et al. | CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707764 |
Song NR et al. | Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. | 2013 | Cancer Prev Res (Phila) | pmid:24104352 |
Seon MR et al. | Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells. | 2012 | J. Nutr. Biochem. | pmid:21429724 |
Li J et al. | Isoangustone A suppresses mesangial fibrosis and inflammation in human renal mesangial cells. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21367880 |
Seon MR et al. | Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway. | 2010 | Mol Nutr Food Res | pmid:20229524 |
Lee YS et al. | Rapid identification and preparative isolation of antioxidant components in licorice. | 2010 | J Sep Sci | pmid:20112307 |
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