| MeSH term | MeSH ID | Detail |
|---|---|---|
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Neoplasms, Germ Cell and Embryonal | D009373 | 4 associated lipids |
Total
4
Tectorigenin
Tectorigenin is a lipid of Polyketides (PK) class. Tectorigenin is associated with abnormalities such as Estrogenic effect. The involved functions are known as Phosphorylation, Metabolic Inhibition, Signal, AKT Signaling Pathway and Signal Transduction. Tectorigenin often locates in Skeletal system, Solitary microtubule component of centriole or axonemal complex, Blood and Entire gastrointestinal tract. The associated genes with Tectorigenin are IKBKE gene, BCL2 gene, CFLAR gene, XIAP gene and BCL2L1 gene. The related lipids are 21-hydroxy-9beta,10alpha-pregna-5,7-diene-3-ol-20-one.
Cross Reference
Introduction
To understand associated biological information of Tectorigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tectorigenin?
Tectorigenin is suspected in Estrogenic effect and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tectorigenin
PubChem Associated disorders and diseases
What pathways are associated with Tectorigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tectorigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tectorigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tectorigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Tectorigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tectorigenin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Tectorigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee SY et al. | Tectorigenin Promotes Osteoblast Differentiation and Bone Healing, but Suppresses Osteoclast Differentiation and Bone Resorption. | 2018 | Mol. Cells | pmid:29764006 |
| Zeng L et al. | Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro. | 2018 | Mol Med Rep | pmid:29359782 |
| BukviÄki D et al. | Secondary metabolites from endemic species Iris adriatica Trinajstić ex Mitić (Iridaceae). | 2018 | Nat. Prod. Res. | pmid:29126369 |
| Applová L et al. | The isoflavonoid tectorigenin has better antiplatelet potential than acetylsalicylic acid. | 2017 | Phytomedicine | pmid:28991640 |
| Zhang Y et al. | Characterization and evaluation of a self-microemulsifying drug delivery system containing tectorigenin, an isoflavone with low aqueous solubility and poor permeability. | 2017 | Drug Deliv | pmid:28283000 |
| Zhang R et al. | Protective Effect of an Isoflavone, Tectorigenin, Against Oxidative Stress-induced Cell Death via Catalase Activation. | 2016 | J Cancer Prev | pmid:28053960 |
| Zhan G et al. | Antitumor, Antioxidant, and Nitrite Scavenging Effects of Chinese Water Chestnut (Eleocharis dulcis) Peel Flavonoids. | 2016 | J. Food Sci. | pmid:27603811 |
| Guo Y et al. | Tectorigenin inhibits osteosarcoma cell migration through downregulation of matrix metalloproteinases in vitro. | 2016 | Anticancer Drugs | pmid:26991068 |
| Gampe N et al. | Characterization and identification of isoflavonoid glycosides in the root of Spiny restharrow (Ononis spinosa L.) by HPLC-QTOF-MS, HPLC-MS/MS and NMR. | 2016 | J Pharm Biomed Anal | pmid:26874257 |
| Yang M et al. | Comparative pharmacokinetic profiles of tectorigenin in rat plasma by UPLC-MS/MS after oral administration of Iris tectorum Maxim extract and pure tectoridin. | 2015 | J Pharm Biomed Anal | pmid:26004225 |
| Li QY et al. | Tectorigenin regulates adipogenic differentiation and adipocytokines secretion via PPARγ and IKK/NF-κB signaling. | 2015 | Pharm Biol | pmid:25856699 |
| Amin A et al. | Tectorigenin ablates the inflammation-induced epithelial-mesenchymal transition in a co-culture model of human lung carcinoma. | 2015 | Pharmacol Rep | pmid:25712668 |
| Shuai S et al. | Preparation, characterization and in vitro/vivo evaluation of tectorigenin solid dispersion with improved dissolution and bioavailability. | 2016 | Eur J Drug Metab Pharmacokinet | pmid:25669445 |
| Ma CH et al. | Tectorigenin inhibits the inflammation of LPS-induced acute lung injury in mice. | 2014 | Chin J Nat Med | pmid:25480515 |
| Shi Z et al. | Excretion of tectorigenin in rat urine orally administrated at different dosages by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. | 2015 | Eur J Drug Metab Pharmacokinet | pmid:24789580 |
| Tarbeeva DV et al. | Polyphenolic compounds from callus cultures of Iris pseudacorus. | 2013 | Nat Prod Commun | pmid:24354190 |
| Wang H et al. | Metabolism and excretion of kakkalide and its metabolites in rat urine, bile, and feces as determined by HPLC/UV and LC/MS/MS. | 2013 | Planta Med. | pmid:24108437 |
| Hasibeder A et al. | Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors. | 2013 | Int. J. Oncol. | pmid:23969837 |
| Wang S et al. | Simultaneous determination of tectorigenin and its metabolites in rat plasma by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23872519 |
| Wang Q et al. | Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway. | 2013 | PLoS ONE | pmid:23840461 |
| Ha le M et al. | Toxicity, analgesic and anti-inflammatory activities of tectorigenin. | 2013 | Immunopharmacol Immunotoxicol | pmid:23461431 |
| Wang Q et al. | Application of an efficient strategy for discovery and purification of bioactive compounds from Chinese herbal medicines, a case study on the Puerariae thomsonii Flos. | 2013 | J Pharm Biomed Anal | pmid:23312381 |
| Yang YI et al. | Tectorigenin sensitizes paclitaxel-resistant human ovarian cancer cells through downregulation of the Akt and NFκB pathway. | 2012 | Carcinogenesis | pmid:23027625 |
| Jun HJ et al. | Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells. | 2012 | Biotechnol. Lett. | pmid:23011313 |
| Gao XX et al. | The therapeutic effects of tectorigenin on chemically induced liver fibrosis in rats and an associated metabonomic investigation. | 2012 | Arch. Pharm. Res. | pmid:22941492 |
| Qu J et al. | Pharmacokinetics of conjugated metabolites in rat plasma after oral administration of tectoridin. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22771104 |
| Kamiya T et al. | The crude extract from puerariae flower exerts antiobesity and antifatty liver effects in high-fat diet-induced obese mice. | 2012 | Evid Based Complement Alternat Med | pmid:22685484 |
| Liu M et al. | Chemical constituents of the ethyl acetate extract of Belamcanda chinensis (L.) DC roots and their antitumor activities. | 2012 | Molecules | pmid:22627971 |
| Jiang CP et al. | Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells. | 2012 | World J. Gastroenterol. | pmid:22553399 |
| Liu L et al. | Screening and identification of BSA bound ligands from Puerariae lobata flower by BSA functionalized Fe₃O₄ magnetic nanoparticles coupled with HPLC-MS/MS. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22305973 |
| Galvez-Llompart M et al. | Modeling natural anti-inflammatory compounds by molecular topology. | 2011 | Int J Mol Sci | pmid:22272145 |
| Han T et al. | In vitro evaluation of tectoridin, tectorigenin and tectorigenin sodium sulfonate on antioxidant properties. | 2012 | Food Chem. Toxicol. | pmid:22079309 |
| Xia XM et al. | CXCR4 antagonist AMD3100 modulates claudin expression and intestinal barrier function in experimental colitis. | 2011 | PLoS ONE | pmid:22073304 |
| Zhang WD et al. | Simultaneous determination of tectorigenin, irigenin and irisflorentin in rat plasma and urine by UHPLC-MS/MS: application to pharmacokinetics. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22071270 |
| Kang KA et al. | KIOM-4 Protects against Oxidative Stress-Induced Mitochondrial Damage in Pancreatic β-cells via Its Antioxidant Effects. | 2011 | Evid Based Complement Alternat Med | pmid:21799698 |
| Park JS et al. | Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression. | 2011 | J. Neurochem. | pmid:21781119 |
| Zhang YY et al. | Characterization and determination of the major constituents in Belamcandae Rhizoma by HPLC-DAD-ESI-MS(n). | 2011 | J Pharm Biomed Anal | pmid:21715119 |
| Lim MP et al. | Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis. | 2011 | Cell Death Dis | pmid:21654828 |
| Lee YS et al. | Preparative isolation and purification of seven isoflavones from Belamcanda chinensis. | Phytochem Anal | pmid:21465599 | |
| Xiao J et al. | ZnO-ZnS QDs interfacial heterostructure for drug and food delivery application: enhancement of the binding affinities of flavonoid aglycones to bovine serum albumin. | 2011 | Nanomedicine | pmid:21371570 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Ablajan K | A study of characteristic fragmentation of isoflavonoids by using negative ion ESI-MSn. | 2011 | J Mass Spectrom | pmid:21182215 |
| Liu L et al. | [Simultaneous determination of tectorigenin-7-O-xylosylglucosid, tectoridin and tectorigenin in flowers of Pueraria lobata by HPLC]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21137344 |
| Wang J et al. | [Effect of tectorigenin on MCP-1 and ICAM-1 mRNA expression in injured vascular endothelial cells]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20931855 |
| Zhang R et al. | Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress. | 2011 | Evid Based Complement Alternat Med | pmid:20924496 |
| Choi CW et al. | Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. | 2010 | J. Agric. Food Chem. | pmid:20734984 |
| Wu JH et al. | Anti-proliferative and pro-apoptotic effects of tectorigenin on hepatic stellate cells. | 2010 | World J. Gastroenterol. | pmid:20712052 |
| Tamura S et al. | Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20627560 |
| Zhang H et al. | Tectorigenin inhibits the in vitro proliferation and enhances miR-338* expression of pulmonary fibroblasts in rats with idiopathic pulmonary fibrosis. | 2010 | J Ethnopharmacol | pmid:20600766 |
| Yao M et al. | Quantitative analysis of two isoflavones in Pueraria lobata flowers from eleven Chinese provinces using high performance liquid chromatography. | 2010 | Chin Med | pmid:20416072 |