Tectorigenin

Tectorigenin is a lipid of Polyketides (PK) class. Tectorigenin is associated with abnormalities such as Estrogenic effect. The involved functions are known as Phosphorylation, Metabolic Inhibition, Signal, AKT Signaling Pathway and Signal Transduction. Tectorigenin often locates in Skeletal system, Solitary microtubule component of centriole or axonemal complex, Blood and Entire gastrointestinal tract. The associated genes with Tectorigenin are IKBKE gene, BCL2 gene, CFLAR gene, XIAP gene and BCL2L1 gene. The related lipids are 21-hydroxy-9beta,10alpha-pregna-5,7-diene-3-ol-20-one.

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Introduction

To understand associated biological information of Tectorigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tectorigenin?

Tectorigenin is suspected in Estrogenic effect and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tectorigenin

MeSH term MeSH ID Detail
Hyperglycemia D006943 21 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Atherosclerosis D050197 85 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Tectorigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tectorigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tectorigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tectorigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Tectorigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tectorigenin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Tectorigenin

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Authors Title Published Journal PubMed Link
Zeng L et al. Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro. 2018 Mol Med Rep pmid:29359782
Bukvički D et al. Secondary metabolites from endemic species Iris adriatica Trinajstić ex Mitić (Iridaceae). 2018 Nat. Prod. Res. pmid:29126369
Lee SY et al. Tectorigenin Promotes Osteoblast Differentiation and Bone Healing, but Suppresses Osteoclast Differentiation and Bone Resorption. 2018 Mol. Cells pmid:29764006
Applová L et al. The isoflavonoid tectorigenin has better antiplatelet potential than acetylsalicylic acid. 2017 Phytomedicine pmid:28991640
Zhang Y et al. Characterization and evaluation of a self-microemulsifying drug delivery system containing tectorigenin, an isoflavone with low aqueous solubility and poor permeability. 2017 Drug Deliv pmid:28283000
Zhan G et al. Antitumor, Antioxidant, and Nitrite Scavenging Effects of Chinese Water Chestnut (Eleocharis dulcis) Peel Flavonoids. 2016 J. Food Sci. pmid:27603811
Guo Y et al. Tectorigenin inhibits osteosarcoma cell migration through downregulation of matrix metalloproteinases in vitro. 2016 Anticancer Drugs pmid:26991068
Shuai S et al. Preparation, characterization and in vitro/vivo evaluation of tectorigenin solid dispersion with improved dissolution and bioavailability. 2016 Eur J Drug Metab Pharmacokinet pmid:25669445
Zhang R et al. Protective Effect of an Isoflavone, Tectorigenin, Against Oxidative Stress-induced Cell Death via Catalase Activation. 2016 J Cancer Prev pmid:28053960
Gampe N et al. Characterization and identification of isoflavonoid glycosides in the root of Spiny restharrow (Ononis spinosa L.) by HPLC-QTOF-MS, HPLC-MS/MS and NMR. 2016 J Pharm Biomed Anal pmid:26874257
Yang M et al. Comparative pharmacokinetic profiles of tectorigenin in rat plasma by UPLC-MS/MS after oral administration of Iris tectorum Maxim extract and pure tectoridin. 2015 J Pharm Biomed Anal pmid:26004225
Li QY et al. Tectorigenin regulates adipogenic differentiation and adipocytokines secretion via PPARγ and IKK/NF-κB signaling. 2015 Pharm Biol pmid:25856699
Amin A et al. Tectorigenin ablates the inflammation-induced epithelial-mesenchymal transition in a co-culture model of human lung carcinoma. 2015 Pharmacol Rep pmid:25712668
Shi Z et al. Excretion of tectorigenin in rat urine orally administrated at different dosages by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. 2015 Eur J Drug Metab Pharmacokinet pmid:24789580
Ma CH et al. Tectorigenin inhibits the inflammation of LPS-induced acute lung injury in mice. 2014 Chin J Nat Med pmid:25480515
Wang S et al. Simultaneous determination of tectorigenin and its metabolites in rat plasma by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. 2013 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23872519
Wang Q et al. Application of an efficient strategy for discovery and purification of bioactive compounds from Chinese herbal medicines, a case study on the Puerariae thomsonii Flos. 2013 J Pharm Biomed Anal pmid:23312381
Hasibeder A et al. Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors. 2013 Int. J. Oncol. pmid:23969837
Ha le M et al. Toxicity, analgesic and anti-inflammatory activities of tectorigenin. 2013 Immunopharmacol Immunotoxicol pmid:23461431
Wang H et al. Metabolism and excretion of kakkalide and its metabolites in rat urine, bile, and feces as determined by HPLC/UV and LC/MS/MS. 2013 Planta Med. pmid:24108437