29623-28-7

29623-28-7 is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1002 references associated with 29623-28-7 in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 29623-28-7

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 29623-28-7

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Thrombosis D013927 49 associated lipids
Arteriosclerosis D001161 86 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Hypertension D006973 115 associated lipids
Familial Mediterranean Fever D010505 12 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Per page 10 20 | Total 11

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 29623-28-7

Download all related citations
Per page 10 20 50 100 | Total 229
Authors Title Published Journal PubMed Link
Kelavkar UP et al. Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis. 2001 Carcinogenesis pmid:11698337
Nagy L et al. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. 1998 Cell pmid:9568715
Liu B et al. Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C. 1991 Cell Regul. pmid:1801923
Mani I et al. Upregulation of nuclear PKC and MAP-kinase during hyperproliferation of guinea pig epidermis: modulation by 13-(S)-hydroxyoctadecadienoic acid (13-HODE). 1998 Cell. Signal. pmid:9481490
Jira W et al. Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients. 1998 Chem. Phys. Lipids pmid:9488997
Batna A et al. Lipid peroxidation in presence of ebselen. 1997 Chem. Phys. Lipids pmid:9275309
Jira W et al. Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis. 1997 Chem. Phys. Lipids pmid:9219348
Manini P et al. Biomimetic nitration of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid: isolation and spectral characterization of novel chain-rearranged epoxy nitro derivatives. 2008 Chem. Phys. Lipids pmid:18320610
Manini P et al. Free radical oxidation of coriolic acid (13-(S)-hydroxy-9Z,11E-octadecadienoic acid). 2005 Chem. Phys. Lipids pmid:15784234
Liu W et al. Ex vivo oxidation in tissue and plasma assays of hydroxyoctadecadienoates: Z,E/E,E stereoisomer ratios. 2010 Chem. Res. Toxicol. pmid:20423158
Schneider C et al. Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. 2004 Chem. Res. Toxicol. pmid:15257619
De Meyer GR et al. Neointima formation impairs endothelial muscarinic receptors while enhancing prostacyclin-mediated responses in the rabbit carotid artery. 1991 Circ. Res. pmid:1645234
Klawitter J et al. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. 2015 Clin J Am Soc Nephrol pmid:26224879
Dauchy RT et al. Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids. 2007 Comp. Med. pmid:17803052
Li MY et al. Pioglitazone prevents smoking carcinogen-induced lung tumor development in mice. 2012 Curr Cancer Drug Targets pmid:22463586
Imaizumi S et al. L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. 2010 Drug Metab Lett pmid:20642447
Jude AR et al. 13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases. 2001 Drug Metab. Dispos. pmid:11302930
Chouinard S et al. Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation. 2006 Endocrinology pmid:16887906
Sakashita T et al. Essential involvement of 12-lipoxygenase in regiospecific andstereospecific oxidation of low density lipoprotein by macrophages. 1999 Eur. J. Biochem. pmid:10504415
Henricks PA et al. 13-hydroxy-linoleic acid induces airway hyperreactivity to histamine in guinea-pigs. 1991 Eur. J. Pharmacol. pmid:1915571
Buckley TL et al. 13-hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4 in vivo in rabbit skin. 1992 Eur. J. Pharmacol. pmid:1330604
Grøn B et al. Distribution of monohydroxy fatty acids in specific human epidermal phospholipids. 1993 Exp. Dermatol. pmid:8156169
van de Velde MJ et al. The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes. 1995 FEBS Lett. pmid:7649276
Inouye S Site-specific cleavage of double-strand DNA by hydroperoxide of linoleic acid. 1984 FEBS Lett. pmid:6430718
Elékés E et al. Suppression of endotoxin mitogenicity of spleen cells by lipoxygenase inhibitors and its reversal by 13-hydroxyoctadecadienoic acid. 1993 FEMS Immunol. Med. Microbiol. pmid:8472013
Metzger K et al. Lipoxygenase products in human saliva: patients with oral cancer compared to controls. 1995 Free Radic. Biol. Med. pmid:7744301
Guo L et al. Preferential formation of the hydroperoxide of linoleic acid in choline glycerophospholipids in human erythrocytes membrane during peroxidation with an azo initiator. 1995 Free Radic. Biol. Med. pmid:7628726
Coleman JD et al. The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). 2007 Free Radic. Biol. Med. pmid:17382197
Gryglewski RJ et al. Mediators produced by the endothelial cell. 1988 Hypertension pmid:3060428
Pomposiello SI et al. Linoleic acid induces relaxation and hyperpolarization of the pig coronary artery. 1998 Hypertension pmid:9461230
Czimmerer Z et al. Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophages. 2012 Immunobiology pmid:22954708
Rolin J et al. Oxidized lipids and lysophosphatidylcholine induce the chemotaxis and intracellular calcium influx in natural killer cells. 2013 Immunobiology pmid:23200035
Viita H et al. 15-Lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma. 2012 Jan-Feb In Vivo pmid:22210710
Blask DE et al. Circadian stage-dependent inhibition of human breast cancer metabolism and growth by the nocturnal melatonin signal: consequences of its disruption by light at night in rats and women. 2009 Integr Cancer Ther pmid:20042410
Hübke H et al. Characterization and quantification of free and esterified 9- and 13-hydroxyoctadecadienoic acids (HODE) in barley, germinating barley, and finished malt. 2005 J. Agric. Food Chem. pmid:15740040
Cho H et al. Conjugated linoleic acid, cis-9,trans-11, is a substrate for pulmonary 15-lipoxygenase-1 in rat. 2005 J. Agric. Food Chem. pmid:16131140
Mabalirajan U et al. Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. 2009 J. Appl. Physiol. pmid:19628725
Buchanan MR et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. 1985 J. Biol. Chem. pmid:3934168
Askari B et al. Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells. 2002 J. Biol. Chem. pmid:12138107
Ek-Von Mentzer BA et al. Binding of 13-HODE and 15-HETE to phospholipid bilayers, albumin, and intracellular fatty acid binding proteins. implications for transmembrane and intracellular transport and for protection from lipid peroxidation. 2001 J. Biol. Chem. pmid:11278949
Hsi LC et al. 15-lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway. 2001 J. Biol. Chem. pmid:11447213
Kim YS et al. The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kappa b in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7. 2001 J. Biol. Chem. pmid:11448950
Hsi LC et al. Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma. 2002 J. Biol. Chem. pmid:12189136
Hatley ME et al. Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice. 2003 J. Biol. Chem. pmid:12734208
Cimen I et al. 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma. 2011 J. Cell. Biochem. pmid:21544861
Dandona P et al. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. 2001 J. Clin. Endocrinol. Metab. pmid:11232024
Aljada A et al. Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action? 2001 J. Clin. Endocrinol. Metab. pmid:11443197
Schild RL et al. The activity of PPAR gamma in primary human trophoblasts is enhanced by oxidized lipids. 2002 J. Clin. Endocrinol. Metab. pmid:11889173
Aljada A et al. Troglitazone reduces the expression of PPARgamma while stimulating that of PPARalpha in mononuclear cells in obese subjects. 2001 J. Clin. Endocrinol. Metab. pmid:11443177
Han KH et al. Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma. 2000 J. Clin. Invest. pmid:10995790
Folcik VA et al. Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques. 1995 J. Clin. Invest. pmid:7615823
Kühn H et al. In vivo action of 15-lipoxygenase in early stages of human atherogenesis. 1997 J. Clin. Invest. pmid:9062346
Ikawa H et al. Arachidonate 12-lipoxygenase in porcine anterior pituitary cells: its localization and possible function in gonadotrophs. 1996 J. Endocrinol. pmid:8568469
Kühn H et al. Involvement of 15-lipoxygenase in early stages of atherogenesis. 1994 J. Exp. Med. pmid:8195716
Yoshinaga M et al. The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds. 2007 J. Gastroenterol. Hepatol. pmid:17559385
Matzner Y et al. Generation of lipid neutrophil chemoattractant by irradiated bovine aortic endothelial cells. 1988 J. Immunol. pmid:3128604
Black LL et al. Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice. 2015 J. Immunol. pmid:26466956
Fischer B et al. Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma. 2002 J. Immunol. pmid:11884452
Coutant F et al. Sensing environmental lipids by dendritic cell modulates its function. 2004 J. Immunol. pmid:14688309
Duell EA et al. Determination of 5,12, and 15-lipoxygenase products in keratomed biopsies of normal and psoriatic skin. 1988 J. Invest. Dermatol. pmid:2844912
Godessart N et al. Prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with interleukin-1beta. 1996 J. Invest. Dermatol. pmid:8875957
Miller CC and Ziboh VA Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). 1990 J. Invest. Dermatol. pmid:2106562
Ogawa E et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. 2011 J. Invest. Dermatol. pmid:21068754
Mani I et al. Evidence of nuclear PKC/MAP-kinase cascade in guinea pig model of epidermal hyperproliferation. 1999 J. Invest. Dermatol. pmid:9886262
van de Velde MJ et al. 13-HODE inhibits the intracellular calcium increase of activated human polymorphonuclear cells. 1994 J. Leukoc. Biol. pmid:8071595
Rolin J and Maghazachi AA Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. 2014 J. Leukoc. Biol. pmid:24493826
Cho Y and Ziboh VA Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol. 1994 J. Lipid Res. pmid:8169529
Thomas CE et al. Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells. 1994 J. Lipid Res. pmid:8014577
Meilhac O et al. Lipid peroxides induce expression of catalase in cultured vascular cells. 2000 J. Lipid Res. pmid:10946007
Nikkari T et al. Monitoring of lipoprotein oxidation by gas chromatographic analysis of hydroxy fatty acids. 1995 J. Lipid Res. pmid:7706944
Hui R et al. Epidermal growth factor-stimulated production of esterified 13(S)-hydroxyoctadecadienoic acid is associated with tumor suppressor phenotype in Syrian hamster embryo fibroblasts. 1997 J. Lipid Res. pmid:9034199
Fang X et al. 13-(S)-hydroxyoctadecadienoic acid (13-HODE) incorporation and conversion to novel products by endothelial cells. 1999 J. Lipid Res. pmid:10191294
Akiba S et al. Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification. 2003 J. Lipid Res. pmid:12777475
Murthy S et al. 13-hydroxy octadecadienoic acid (13-HODE) inhibits triacylglycerol-rich lipoprotein secretion by CaCo-2 cells. 1998 J. Lipid Res. pmid:9643357
Kang LT and Vanderhoek JY Mono (S) hydroxy fatty acids: novel ligands for cytosolic actin. 1998 J. Lipid Res. pmid:9684751
Folcik VA and Cathcart MK Predominance of esterified hydroperoxy-linoleic acid in human monocyte-oxidized LDL. 1994 J. Lipid Res. pmid:7806971
Baer AN et al. Stereospecificity of the products of the fatty acid oxygenases derived from psoriatic scales. 1991 J. Lipid Res. pmid:1906083
Daret D et al. Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production. 1993 J. Lipid Res. pmid:8228632
Su BN et al. Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora. 2003 J. Nat. Prod. pmid:12932130
Shureiqi I et al. 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. 2000 J. Natl. Cancer Inst. pmid:10904086
Cho Y and Ziboh VA Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective down regulation of protein kinase C-beta. 1995 J. Nutr. pmid:7472653
Fischer SM et al. Arachidonate has protumor-promoting action that is inhibited by linoleate in mouse skin carcinogenesis. 1996 J. Nutr. pmid:8642440
Khan-Merchant N et al. Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. 2002 J. Nutr. pmid:12421837
Sauer LA et al. Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway. 2005 J. Nutr. pmid:16140887
Li D et al. Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. 2015 J. Nutr. pmid:25833778
Sauer LA et al. Dietary factors and growth and metabolism in experimental tumors. 2007 J. Nutr. Biochem. pmid:17418560
Stachowska E et al. Apolipoprotein E4 allele is associated with substantial changes in the plasma lipids and hyaluronic acid content in patients with nonalcoholic fatty liver disease. 2013 J. Physiol. Pharmacol. pmid:24388885
Zha K et al. LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation. 2015 Lipids Health Dis pmid:26302822
Kämmerer I et al. 13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages. 2011 Lipids Health Dis pmid:22129452
Buchanan MR and Bastida E Endothelium and underlying membrane reactivity with platelets, leukocytes and tumor cells: regulation by the lipoxygenase-derived fatty acid metabolites, 13-HODE and HETES. 1988 Med. Hypotheses pmid:3147361
Ruparel S et al. The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 2012 Mol Pain pmid:23006841
Kim JS et al. Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. 2005 Mol. Cancer Res. pmid:16179498
Glasgow WC et al. Regulation of 13(S)-hydroxyoctadecadienoic acid biosynthesis in Syrian hamster embryo fibroblasts by the epidermal growth factor receptor tyrosine kinase. 1996 Mol. Pharmacol. pmid:8649342
Smith LC et al. Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats. 2006 Nutr Cancer pmid:17474866
Zuo X et al. Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. 2006 Oncogene pmid:16288226
Chang J et al. 12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models. 2015 Oncotarget pmid:25576922
Gerhardt B et al. Lipoxygenase-mediated metabolism of storage lipids in germinating sunflower cotyledons and beta-oxidation of (9Z,11E,13S)-13-hydroxy-octadeca-9,11-dienoic acid by the cotyledonary glyoxysomes. 2005 Planta pmid:15526214
Weichert H et al. Metabolic profiling of oxylipins in germinating cucumber seedlings--lipoxygenase-dependent degradation of triacylglycerols and biosynthesis of volatile aldehydes. 2002 Planta pmid:12172844
Gouveia-Figueira S et al. Serum levels of oxylipins in achilles tendinopathy: an exploratory study. 2015 PLoS ONE pmid:25875933
Leghmar K et al. Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures. 2015 PLoS ONE pmid:26171612