rotenone
rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of rotenone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rotenone?
rotenone is suspected in Parkinson Disease, Ischemia, Parkinsonian Disorders, Renal tubular disorder, Morphologically altered structure, Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rotenone
PubChem Associated disorders and diseases
What pathways are associated with rotenone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rotenone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with rotenone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rotenone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rotenone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with rotenone?
Knock-out
Knock-out are used in the study 'Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.' (Revet I et al., 2011).
Mouse Model
Mouse Model are used in the study 'Inhibitors of metabolism rescue cell death in Huntington's disease models.' (Varma H et al., 2007) and Mouse Model are used in the study 'Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.' (Nair AS et al., 2006).
Rodent Model
Rodent Model are used in the study 'Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.' (Worth AJ et al., 2014) and Rodent Model are used in the study 'The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.' (Hwang RD et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with rotenone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pisani L et al. | Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors. | 2019 | Eur J Med Chem | pmid:30366255 |
| Perez-Pardo P et al. | Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet. | 2018 | Nutr Neurosci | pmid:28276272 |
| Balakrishnan R et al. | Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis. | 2018 | Front Biosci (Schol Ed) | pmid:28930531 |
| Lakkappa N et al. | Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS/MS method development. | 2018 | J Pharm Biomed Anal | pmid:29169114 |
| Engel DF et al. | Duloxetine Protects Human Neuroblastoma Cells from Oxidative Stress-Induced Cell Death Through Akt/Nrf-2/HO-1 Pathway. | 2018 | Neurochem. Res. | pmid:29134401 |
| Kim C et al. | Cyclin-dependent kinase 5-mediated phosphorylation of CHIP promotes the tAIF-dependent death pathway in rotenone-treated cortical neurons. | 2018 | Neurosci. Lett. | pmid:29111393 |
| Bai XX et al. | Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson's disease model. | 2018 | Toxicol. Lett. | pmid:29458170 |
| Lin D et al. | Novel biomolecular information in rotenone-induced cellular model of Parkinson's disease. | 2018 | Gene | pmid:29331484 |
| Almeida MF et al. | Effects of mild running on substantia nigra during early neurodegeneration. | 2018 | J Sports Sci | pmid:28895489 |
| Jiang C et al. | Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells. | 2018 | Toxicology | pmid:30205151 |