rotenone
rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of rotenone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rotenone?
rotenone is suspected in Parkinson Disease, Ischemia, Parkinsonian Disorders, Renal tubular disorder, Morphologically altered structure, Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rotenone
PubChem Associated disorders and diseases
What pathways are associated with rotenone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rotenone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with rotenone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rotenone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rotenone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with rotenone?
Knock-out
Knock-out are used in the study 'Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.' (Revet I et al., 2011).
Mouse Model
Mouse Model are used in the study 'Inhibitors of metabolism rescue cell death in Huntington's disease models.' (Varma H et al., 2007) and Mouse Model are used in the study 'Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.' (Nair AS et al., 2006).
Rodent Model
Rodent Model are used in the study 'Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.' (Worth AJ et al., 2014) and Rodent Model are used in the study 'The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.' (Hwang RD et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with rotenone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tomkova S et al. | In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells. | 2018 | Biochim. Biophys. Acta | pmid:29410069 |
| Hsiao YT et al. | Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-[Formula: see text]B Signaling Pathways. | 2018 | Am. J. Chin. Med. | pmid:29402127 |
| Peng K et al. | Mitochondrial ATP-sensitive potassium channel regulates mitochondrial dynamics to participate in neurodegeneration of Parkinson's disease. | 2018 | Biochim. Biophys. Acta | pmid:29353068 |
| Mittraphab Y et al. | Anti-Angiogenic Activity of Rotenoids from the Stems of Derris trifoliata. | 2018 | Planta Med. | pmid:29346807 |
| Zhou H et al. | Melatonin inhibits rotenone-induced SH-SY5Y cell death via the downregulation of Dynamin-Related Protein 1 expression. | 2018 | Eur. J. Pharmacol. | pmid:29183837 |
| Liu S et al. | Ghrelin protects retinal ganglion cells against rotenone via inhibiting apoptosis, restoring mitochondrial function, and activating AKT-mTOR signaling. | 2018 | Neuropeptides | pmid:29174113 |
| Venkatesh Gobi V et al. | Agaricus blazei extract attenuates rotenone-induced apoptosis through its mitochondrial protective and antioxidant properties in SH-SY5Y neuroblastoma cells. | 2018 | Nutr Neurosci | pmid:27646574 |
| Bai XX et al. | Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson's disease model. | 2018 | Toxicol. Lett. | pmid:29458170 |
| Cheng XY et al. | Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. | 2018 | Neuroscience | pmid:29196028 |
| Chao H et al. | Lowered iPLAγ activity causes increased mitochondrial lipid peroxidation and mitochondrial dysfunction in a rotenone-induced model of Parkinson's disease. | 2018 | Exp. Neurol. | pmid:29104115 |