rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.
To understand associated biological information of rotenone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rotenone is suspected in Parkinson Disease, Ischemia, Parkinsonian Disorders, Renal tubular disorder, Morphologically altered structure, Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with rotenone
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.' (Revet I et al., 2011).
Mouse Model are used in the study 'Inhibitors of metabolism rescue cell death in Huntington's disease models.' (Varma H et al., 2007) and Mouse Model are used in the study 'Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.' (Nair AS et al., 2006).
Rodent Model are used in the study 'Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.' (Worth AJ et al., 2014) and Rodent Model are used in the study 'The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.' (Hwang RD et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Pisani L et al. | Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors. | 2019 | Eur J Med Chem | pmid:30366255 |
Perez-Pardo P et al. | Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet. | 2018 | Nutr Neurosci | pmid:28276272 |
Balakrishnan R et al. | Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis. | 2018 | Front Biosci (Schol Ed) | pmid:28930531 |
Zhou Y et al. | Neuroprotective effect of angiotensin-(1-7) against rotenone-induced oxidative damage in CATH.a neurons. | 2018 | Toxicol In Vitro | pmid:29665408 |
Rasheed MZ et al. | Melatonin Improves Behavioral and Biochemical Outcomes in a Rotenone-Induced Rat Model of Parkinson's Disease. | 2018 | J. Environ. Pathol. Toxicol. Oncol. | pmid:30055549 |
Teerapattarakan N et al. | Neuroprotective effect of a standardized extract of Centella asiatica ECa233 in rotenone-induced parkinsonism rats. | 2018 | Phytomedicine | pmid:29895494 |
Huang CW et al. | Multiple Actions of Rotenone, an Inhibitor of Mitochondrial Respiratory Chain, on Ionic Currents and Miniature End-Plate Potential in Mouse Hippocampal (mHippoE-14) Neurons. | 2018 | Cell. Physiol. Biochem. | pmid:29768258 |
Stanford KR and Taylor-Clark TE | Mitochondrial modulation-induced activation of vagal sensory neuronal subsets by antimycin A, but not CCCP or rotenone, correlates with mitochondrial superoxide production. | 2018 | PLoS ONE | pmid:29734380 |
Mihoub M et al. | Bidesmosidic betulin saponin bearing L-rhamnopyranoside moieties induces apoptosis and inhibition of lung cancer cells growth in vitro and in vivo. | 2018 | PLoS ONE | pmid:29538422 |
Kang W et al. | Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. | 2018 | Int. J. Mol. Med. | pmid:29512685 |
Yang J et al. | Tephrosin attenuates sepsis induced acute lung injury in rats by impeding expression of ICAM-1 and MIP-2. | 2018 | Microb. Pathog. | pmid:29432911 |
Tomkova S et al. | In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells. | 2018 | Biochim. Biophys. Acta | pmid:29410069 |
Hsiao YT et al. | Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-[Formula: see text]B Signaling Pathways. | 2018 | Am. J. Chin. Med. | pmid:29402127 |
Peng K et al. | Mitochondrial ATP-sensitive potassium channel regulates mitochondrial dynamics to participate in neurodegeneration of Parkinson's disease. | 2018 | Biochim. Biophys. Acta | pmid:29353068 |
Mittraphab Y et al. | Anti-Angiogenic Activity of Rotenoids from the Stems of Derris trifoliata. | 2018 | Planta Med. | pmid:29346807 |
Zhou H et al. | Melatonin inhibits rotenone-induced SH-SY5Y cell death via the downregulation of Dynamin-Related Protein 1 expression. | 2018 | Eur. J. Pharmacol. | pmid:29183837 |
Liu S et al. | Ghrelin protects retinal ganglion cells against rotenone via inhibiting apoptosis, restoring mitochondrial function, and activating AKT-mTOR signaling. | 2018 | Neuropeptides | pmid:29174113 |
Lakkappa N et al. | Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS/MS method development. | 2018 | J Pharm Biomed Anal | pmid:29169114 |
Engel DF et al. | Duloxetine Protects Human Neuroblastoma Cells from Oxidative Stress-Induced Cell Death Through Akt/Nrf-2/HO-1 Pathway. | 2018 | Neurochem. Res. | pmid:29134401 |
Kim C et al. | Cyclin-dependent kinase 5-mediated phosphorylation of CHIP promotes the tAIF-dependent death pathway in rotenone-treated cortical neurons. | 2018 | Neurosci. Lett. | pmid:29111393 |
Wang A et al. | Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox). | 2018 | Mol. Cell. Biochem. | pmid:29030732 |
Palle S and Neerati P | Improved neuroprotective effect of resveratrol nanoparticles as evinced by abrogation of rotenone-induced behavioral deficits and oxidative and mitochondrial dysfunctions in rat model of Parkinson's disease. | 2018 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:29411055 |
Leite GO et al. | Protective effect of (-)-α-bisabolol on rotenone-induced toxicity in Drosophila melanogaster. | 2018 | Can. J. Physiol. Pharmacol. | pmid:28881148 |
Hung CH et al. | A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration. | 2018 | Redox Biol | pmid:28837882 |
López-Gallardo E et al. | Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations. | 2018 | Food Chem. Toxicol. | pmid:29991444 |
Tain RW et al. | Imaging short-lived reactive oxygen species (ROS) with endogenous contrast MRI. | 2018 | J Magn Reson Imaging | pmid:28503732 |
Venkatesh Gobi V et al. | Agaricus blazei extract attenuates rotenone-induced apoptosis through its mitochondrial protective and antioxidant properties in SH-SY5Y neuroblastoma cells. | 2018 | Nutr Neurosci | pmid:27646574 |
Bai XX et al. | Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson's disease model. | 2018 | Toxicol. Lett. | pmid:29458170 |
Lin D et al. | Novel biomolecular information in rotenone-induced cellular model of Parkinson's disease. | 2018 | Gene | pmid:29331484 |
Almeida MF et al. | Effects of mild running on substantia nigra during early neurodegeneration. | 2018 | J Sports Sci | pmid:28895489 |
Farombi EO et al. | Garcinia kola seed biflavonoid fraction (Kolaviron), increases longevity and attenuates rotenone-induced toxicity in Drosophila melanogaster. | 2018 | Pestic Biochem Physiol | pmid:29482730 |
Jiang C et al. | Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells. | 2018 | Toxicology | pmid:30205151 |
Harris G et al. | Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone. | 2018 | Arch. Toxicol. | pmid:29955902 |
Wu X et al. | Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29906494 |
Nukui M et al. | The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts. | 2018 | Viruses | pmid:30405048 |
Horst CH et al. | Signature of Aberrantly Expressed microRNAs in the Striatum of Rotenone-Induced Parkinsonian Rats. | 2018 | Neurochem. Res. | pmid:30267378 |
Rubio-Araiz A et al. | Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid. | 2018 | J Neuroinflammation | pmid:30170611 |
Hua H et al. | Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation. | 2018 | Kidney Blood Press. Res. | pmid:30099449 |
Fortalezas S et al. | Creatine Protects Against Cytosolic Calcium Dysregulation, Mitochondrial Depolarization and Increase of Reactive Oxygen Species Production in Rotenone-Induced Cell Death of Cerebellar Granule Neurons. | 2018 | Neurotox Res | pmid:30094708 |
Chen Y et al. | Protective effect of roscovitine against rotenone-induced parkinsonism. | 2018 | Restor. Neurol. Neurosci. | pmid:30056439 |
Chen J et al. | The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway. | 2018 | Cell. Physiol. Biochem. | pmid:30045011 |
Bao XX et al. | Preliminary optimization of a Chinese herbal medicine formula based on the neuroprotective effects in a rat model of rotenone-induced Parkinson's disease. | 2018 | J Integr Med | pmid:29866613 |
Abdel-Rahman M et al. | Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. | 2018 | Biomed. Pharmacother. | pmid:29864896 |
Krishna G and Muralidhara | Oral supplements of inulin during gestation offsets rotenone-induced oxidative impairments and neurotoxicity in maternal and prenatal rat brain. | 2018 | Biomed. Pharmacother. | pmid:29807225 |
Ureshino RP et al. | Effects of Aging in the Striatum and Substantia Nigra of a Parkinson's Disease Animal Model. | 2018 | Toxicol Pathol | pmid:29683090 |
Medeiros-Linard CFB et al. | Anacardic Acids from Cashew Nuts Prevent Behavioral Changes and Oxidative Stress Induced by Rotenone in a Rat Model of Parkinson's Disease. | 2018 | Neurotox Res | pmid:29520721 |
Wu X et al. | Rifampicin Prevents SH-SY5Y Cells from Rotenone-Induced Apoptosis via the PI3K/Akt/GSK-3β/CREB Signaling Pathway. | 2018 | Neurochem. Res. | pmid:29435803 |
Stephano F et al. | Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson's disease model. | 2018 | Sci Rep | pmid:29403026 |
Teixeira J et al. | Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells. | 2018 | Redox Biol | pmid:29331741 |
Cheng XY et al. | Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. | 2018 | Neuroscience | pmid:29196028 |
Chao H et al. | Lowered iPLAγ activity causes increased mitochondrial lipid peroxidation and mitochondrial dysfunction in a rotenone-induced model of Parkinson's disease. | 2018 | Exp. Neurol. | pmid:29104115 |
Menges S et al. | Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. | 2017 | Sci Rep | pmid:28224980 |
Liu HF et al. | Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease. | 2017 | Sci Rep | pmid:28098219 |
Martinez EM et al. | Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice. | 2017 | Toxicol. Sci. | pmid:28903492 |
Honorat JA et al. | Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner. | 2017 | PLoS ONE | pmid:29107957 |
Russell DA et al. | Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone. | 2017 | J. Nat. Prod. | pmid:29039664 |
Khailova LS et al. | Effect of Cyanide on Mitochondrial Membrane Depolarization Induced by Uncouplers. | 2017 | Biochemistry Mosc. | pmid:29037134 |
Aksoy D et al. | Neuroprotective Effects of Eexenatide in a Rotenone-Induced Rat Model of Parkinson's Disease. | 2017 | Am. J. Med. Sci. | pmid:28918840 |
Negro Silva LF et al. | Effects of Inorganic Arsenic, Methylated Arsenicals, and Arsenobetaine on Atherosclerosis in the Mouse Model and the Role of As3mt-Mediated Methylation. | 2017 | Environ. Health Perspect. | pmid:28728140 |
McCabe K et al. | Time-course of striatal Toll-like receptor expression in neurotoxic, environmental and inflammatory rat models of Parkinson's disease. | 2017 | J. Neuroimmunol. | pmid:28778432 |
Qin LX et al. | BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage. | 2017 | Oxid Med Cell Longev | pmid:28348719 |
Hao XM et al. | Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson's disease in differentiated SH-SY5Y cells. | 2017 | J Asian Nat Prod Res | pmid:28696167 |
Preston S et al. | Deguelin exerts potent nematocidal activity the mitochondrial respiratory chain. | 2017 | FASEB J. | pmid:28687609 |
Kawasaki S et al. | Effects of hypnotic bromovalerylurea on microglial BV2 cells. | 2017 | J. Pharmacol. Sci. | pmid:28645489 |
Ježek J et al. | Antioxidant mechanism of mitochondria-targeted plastoquinone SkQ1 is suppressed in aglycemic HepG2 cells dependent on oxidative phosphorylation. | 2017 | Biochim Biophys Acta Bioenerg | pmid:28554565 |
Ebrahimi SS et al. | Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease. | 2017 | Toxicol. Lett. | pmid:28526446 |
Zhang X et al. | Deguelin induced differentiation of mutated NPM1 acute myeloid leukemia in vivo and in vitro. | 2017 | Anticancer Drugs | pmid:28471807 |
Voronkov DN et al. | Immunomorphological Changes in the Olfactory Bulbs of Rats after Intranasal Administration of Rotenone. | 2017 | Bull. Exp. Biol. Med. | pmid:29181664 |
Yu X et al. | Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma. | 2017 | EBioMedicine | pmid:29129699 |
Shen D et al. | Mechanistic evaluation of neuroprotective effect of estradiol on rotenone and 6-OHDA induced Parkinson's disease. | 2017 | Pharmacol Rep | pmid:29128798 |
Yang Q et al. | Synthesis and neuroprotective effects of the complex nanoparticles of iron and sapogenin isolated from the defatted seeds of Camellia oleifera. | 2017 | Pharm Biol | pmid:27937035 |
Nakamura K et al. | Stereocontrolled Total Syntheses of (-)-Rotenone and (-)-Dalpanol by 1,2-Rearrangement and S Ar Oxycyclizations. | 2017 | Angew. Chem. Int. Ed. Engl. | pmid:27910179 |
Ling S et al. | Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I. | 2017 | Cell Death Dis | pmid:29095437 |
Khadrawy YA et al. | Cerebellar neurochemical and histopathological changes in rat model of Parkinson's disease induced by intrastriatal injection of rotenone. | 2017 | Gen. Physiol. Biophys. | pmid:27901474 |
Barton GP et al. | Linking metabolic and contractile dysfunction in aged cardiac myocytes. | 2017 | Physiol Rep | pmid:29084842 |
Zhang ZN et al. | Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study. | 2017 | Brain Res. | pmid:27876560 |
Liu XM et al. | Ammonia promotes endothelial cell survival via the heme oxygenase-1-mediated release of carbon monoxide. | 2017 | Free Radic. Biol. Med. | pmid:27867098 |
Wang Y et al. | Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish. | 2017 | Neurotoxicology | pmid:27866991 |
Shen J et al. | Correlation between circuital current, Cu(II) reduction and cellular electron transfer in EAB isolated from Cu(II)-reduced biocathodes of microbial fuel cells. | 2017 | Bioelectrochemistry | pmid:27835761 |
Khera A et al. | Overexpression of Endogenous Anti-Oxidants with Selenium Supplementation Protects Trophoblast Cells from Reactive Oxygen Species-Induced Apoptosis in a Bcl-2-Dependent Manner. | 2017 | Biol Trace Elem Res | pmid:27817049 |
Yee AG et al. | Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone. | 2017 | Exp. Neurol. | pmid:27771354 |
Barreca D et al. | Neuroprotective effects of phloretin and its glycosylated derivative on rotenone-induced toxicity in human SH-SY5Y neuronal-like cells. | 2017 | Biofactors | pmid:28401997 |
Romero A et al. | Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®). | 2017 | CNS Neurosci Ther | pmid:28371323 |
Kishore Kumar SN et al. | Morinda citrifolia mitigates rotenone-induced striatal neuronal loss in male Sprague-Dawley rats by preventing mitochondrial pathway of intrinsic apoptosis. | 2017 | Redox Rep. | pmid:27882828 |
Negro S et al. | Efficacy of Ropinirole-Loaded PLGA Microspheres for the Reversion of Rotenone- Induced Parkinsonism. | 2017 | Curr. Pharm. Des. | pmid:27779080 |
Michel HE et al. | Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson's Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions. | 2017 | Mol. Neurobiol. | pmid:27514753 |
Ni Y et al. | Investigation of Long Non-coding RNA Expression Profiles in the Substantia Nigra of Parkinson's Disease. | 2017 | Cell. Mol. Neurobiol. | pmid:27151187 |
Uribe P et al. | Nitrosative stress by peroxynitrite impairs ATP production in human spermatozoa. | 2017 | Andrologia | pmid:27135897 |
Dilrukshi Herath HMP et al. | Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus. | 2017 | Vet. Parasitol. | pmid:28917310 |
González-Burgos E et al. | Ginsenosides Rd and Re co-treatments improve rotenone-induced oxidative stress and mitochondrial impairment in SH-SY5Y neuroblastoma cells. | 2017 | Food Chem. Toxicol. | pmid:28843595 |
Kuang L et al. | Baicalein Protects against Rotenone-Induced Neurotoxicity through Induction of Autophagy. | 2017 | Biol. Pharm. Bull. | pmid:28659545 |
Pistollato F et al. | Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes. | 2017 | Neurochem. Int. | pmid:28627367 |
Jagota A and Mattam U | Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin. | 2017 | Biogerontology | pmid:28577110 |
Peng K et al. | The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1α Regulates Rotenone-Induced Dopaminergic Neurotoxicity. | 2017 | Mol. Neurobiol. | pmid:27271125 |
Nataraj J et al. | Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells. | 2017 | Nutr Neurosci | pmid:26856988 |
Baba Y and Kato Y | Deguelin, a Novel Anti-Tumorigenic Agent in Human Esophageal Squamous Cell Carcinoma. | 2017 | EBioMedicine | pmid:29157837 |
Giorgi-Coll S et al. | Succinate supplementation improves metabolic performance of mixed glial cell cultures with mitochondrial dysfunction. | 2017 | Sci Rep | pmid:28432362 |
Heinz S et al. | Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation. | 2017 | Sci Rep | pmid:28374803 |
Fernández-Mosquera L et al. | Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis. | 2017 | Sci Rep | pmid:28345620 |
Kumar R et al. | S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation. | 2017 | Sci Rep | pmid:28300150 |