| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
rotenone
rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of rotenone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rotenone?
rotenone is suspected in Parkinson Disease, Ischemia, Parkinsonian Disorders, Renal tubular disorder, Morphologically altered structure, Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rotenone
PubChem Associated disorders and diseases
What pathways are associated with rotenone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rotenone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rotenone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with rotenone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rotenone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rotenone?
Knock-out
Knock-out are used in the study 'Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.' (Revet I et al., 2011).
Mouse Model
Mouse Model are used in the study 'Inhibitors of metabolism rescue cell death in Huntington's disease models.' (Varma H et al., 2007) and Mouse Model are used in the study 'Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.' (Nair AS et al., 2006).
Rodent Model
Rodent Model are used in the study 'Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.' (Worth AJ et al., 2014) and Rodent Model are used in the study 'The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.' (Hwang RD et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rotenone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhou Y et al. | Neuroprotective effect of angiotensin-(1-7) against rotenone-induced oxidative damage in CATH.a neurons. | 2018 | Toxicol In Vitro | pmid:29665408 |
| Wang A et al. | Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox). | 2018 | Mol. Cell. Biochem. | pmid:29030732 |
| Leite GO et al. | Protective effect of (-)-α-bisabolol on rotenone-induced toxicity in Drosophila melanogaster. | 2018 | Can. J. Physiol. Pharmacol. | pmid:28881148 |
| Wu X et al. | Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29906494 |
| Nukui M et al. | The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts. | 2018 | Viruses | pmid:30405048 |
| Horst CH et al. | Signature of Aberrantly Expressed microRNAs in the Striatum of Rotenone-Induced Parkinsonian Rats. | 2018 | Neurochem. Res. | pmid:30267378 |
| Rubio-Araiz A et al. | Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid. | 2018 | J Neuroinflammation | pmid:30170611 |
| Hua H et al. | Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation. | 2018 | Kidney Blood Press. Res. | pmid:30099449 |
| Fortalezas S et al. | Creatine Protects Against Cytosolic Calcium Dysregulation, Mitochondrial Depolarization and Increase of Reactive Oxygen Species Production in Rotenone-Induced Cell Death of Cerebellar Granule Neurons. | 2018 | Neurotox Res | pmid:30094708 |
| Chen Y et al. | Protective effect of roscovitine against rotenone-induced parkinsonism. | 2018 | Restor. Neurol. Neurosci. | pmid:30056439 |