| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
rotenone
rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of rotenone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rotenone?
rotenone is suspected in Parkinson Disease, Ischemia, Parkinsonian Disorders, Renal tubular disorder, Morphologically altered structure, Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rotenone
PubChem Associated disorders and diseases
What pathways are associated with rotenone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rotenone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rotenone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with rotenone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with rotenone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rotenone?
Knock-out
Knock-out are used in the study 'Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.' (Revet I et al., 2011).
Mouse Model
Mouse Model are used in the study 'Inhibitors of metabolism rescue cell death in Huntington's disease models.' (Varma H et al., 2007) and Mouse Model are used in the study 'Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.' (Nair AS et al., 2006).
Rodent Model
Rodent Model are used in the study 'Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.' (Worth AJ et al., 2014) and Rodent Model are used in the study 'The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.' (Hwang RD et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rotenone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liang S et al. | GAPDH-knockdown reduce rotenone-induced H9C2 cells death via autophagy and anti-oxidative stress pathway. | 2015 | Toxicol. Lett. | pmid:25725130 |
| Khalil WK et al. | Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis. | 2015 | Neurochem. Int. | pmid:25481089 |
| Nassar NN et al. | Saxagliptin: a novel antiparkinsonian approach. | 2015 | Neuropharmacology | pmid:25446674 |
| Tyurina YY et al. | LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. | 2015 | Free Radic. Res. | pmid:25740198 |
| Parameshwaran K et al. | Antioxidant-mediated reversal of oxidative damage in mouse modeling of complex I inhibition. | 2015 | Drug Dev. Res. | pmid:25847731 |
| Dalu T et al. | An Assessment of the Effect of Rotenone on Selected Non-Target Aquatic Fauna. | 2015 | PLoS ONE | pmid:26540301 |
| Bundela S et al. | Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine. | 2015 | PLoS ONE | pmid:26536350 |
| Forkink M et al. | Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells. | 2015 | Redox Biol | pmid:26516986 |
| Ojha S et al. | Neuroprotective potential of ferulic acid in the rotenone model of Parkinson's disease. | 2015 | Drug Des Devel Ther | pmid:26504373 |
| Xia N et al. | Blockade of metabotropic glutamate receptor 5 protects against DNA damage in a rotenone-induced Parkinson's disease model. | 2015 | Free Radic. Biol. Med. | pmid:26454081 |
| Kabiraj P et al. | The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells. | 2015 | Protein J. | pmid:26385697 |
| Nojima Y et al. | Superoxide dismutases, SOD1 and SOD2, play a distinct role in the fat body during pupation in silkworm Bombyx mori. | 2015 | PLoS ONE | pmid:25714339 |
| Liang Y et al. | Toxicity of amorphigenin from the seeds of Amorpha fruticosa against the larvae of Culex pipiens pallens (Diptera: Culicidae). | 2015 | Molecules | pmid:25690287 |
| Xu Q et al. | Targeting metabolic plasticity in breast cancer cells via mitochondrial complex I modulation. | 2015 | Breast Cancer Res. Treat. | pmid:25677747 |
| Yin L et al. | The S-nitrosylation status of PCNA localized in cytosol impacts the apoptotic pathway in a Parkinson's disease paradigm. | 2015 | PLoS ONE | pmid:25675097 |
| Goldstein DS et al. | Rotenone decreases intracellular aldehyde dehydrogenase activity: implications for the pathogenesis of Parkinson's disease. | 2015 | J. Neurochem. | pmid:25645689 |
| Murakami S et al. | Long-Term Systemic Exposure to Rotenone Induces Central and Peripheral Pathology of Parkinson's Disease in Mice. | 2015 | Neurochem. Res. | pmid:25894684 |
| Cappelletti G et al. | Linking microtubules to Parkinson's disease: the case of parkin. | 2015 | Biochem. Soc. Trans. | pmid:25849932 |
| Hsu CG and Burkholder TJ | Activation of p38 in C2C12 myotubes following ATP depletion depends on extracellular glucose. | 2015 | J. Physiol. Biochem. | pmid:25835326 |
| Lagido C et al. | A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans. | 2015 | J Vis Exp | pmid:26554627 |
| Nascimento C et al. | Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction. | 2015 | J Neural Transm (Vienna) | pmid:25261015 |
| Yi S et al. | Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation. | 2015 | Ann. Hematol. | pmid:25242579 |
| Trask OJ et al. | A micropatterned hepatocyte coculture model for assessment of liver toxicity using high-content imaging analysis. | 2014 Jan-Feb | Assay Drug Dev Technol | pmid:24444127 |
| Nguyen HT and Chen M | High-energy compounds mobilize intracellular Ca2+ and activate calpain in cultured cells: is calpain an energy-dependent protease? | 2014 | Brain Res. Bull. | pmid:24508187 |
| Kavitha M et al. | Mangiferin antagonizes rotenone: induced apoptosis through attenuating mitochondrial dysfunction and oxidative stress in SK-N-SH neuroblastoma cells. | 2014 | Neurochem. Res. | pmid:24493626 |
| Wang H et al. | The contribution of Cdc2 in rotenone-induced G2/M arrest and caspase-3-dependent apoptosis. | 2014 | J. Mol. Neurosci. | pmid:24337984 |
| Thakur P and Nehru B | Long-term heat shock proteins (HSPs) induction by carbenoxolone improves hallmark features of Parkinson's disease in a rotenone-based model. | 2014 | Neuropharmacology | pmid:24296154 |
| Ma KL et al. | The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle. | 2014 | Neuropharmacology | pmid:23973294 |
| Kabiraj P et al. | Ellagic acid mitigates SNO-PDI induced aggregation of Parkinsonian biomarkers. | 2014 | ACS Chem Neurosci | pmid:25247703 |
| Ai Q et al. | Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice. | 2014 | Int. Immunopharmacol. | pmid:24830863 |
| Zhang Q et al. | Involvement of ERK1/2 pathway in neuroprotective effects of pyrroloquinoline quinine against rotenone-induced SH-SY5Y cell injury. | 2014 | Neuroscience | pmid:24755484 |
| Ouazia D et al. | Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells. | 2014 | Neuroscience | pmid:24631677 |
| Zhang X et al. | Puerarin protects dopaminergic neurons in Parkinson's disease models. | 2014 | Neuroscience | pmid:25218963 |
| Cleaver JE et al. | Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25136123 |
| Krug AK et al. | Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). | 2014 | Cell Death Dis | pmid:24810058 |
| Rojas-Charry L et al. | Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. | 2014 | Neurotoxicology | pmid:24792327 |
| Mansergh FC et al. | Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy. | 2014 | Eur. J. Hum. Genet. | pmid:24569607 |
| Brouillette MJ et al. | Strain-dependent oxidant release in articular cartilage originates from mitochondria. | 2014 | Biomech Model Mechanobiol | pmid:23896937 |
| Kim JH et al. | Hypoxia induces adipocyte differentiation of adipose-derived stem cells by triggering reactive oxygen species generation. | 2014 | Cell Biol. Int. | pmid:23956071 |
| Zhu M et al. | Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP+. | 2014 | CNS Neurosci Ther | pmid:24351065 |
| Hughes RH et al. | Neuroprotection by genipin against reactive oxygen and reactive nitrogen species-mediated injury in organotypic hippocampal slice cultures. | 2014 | Brain Res. | pmid:24275198 |
| Lim J et al. | Impaired autophagic flux is critically involved in drug-induced dopaminergic neuronal death. | 2014 | Parkinsonism Relat. Disord. | pmid:24262172 |
| Qualls Z et al. | Protective effects of curcumin against rotenone and salsolinol-induced toxicity: implications for Parkinson's disease. | 2014 | Neurotox Res | pmid:24122264 |
| Di Filippo M et al. | Interferon-β1a protects neurons against mitochondrial toxicity via modulation of STAT1 signaling: electrophysiological evidence. | 2014 | Neurobiol. Dis. | pmid:24135008 |
| Du C et al. | Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25086357 |
| Mtimunye PJ and Chirwa EM | Characterization of the biochemical-pathway of uranium (VI) reduction in facultative anaerobic bacteria. | 2014 | Chemosphere | pmid:25065785 |
| Bueno Pérez L et al. | Caeruleanone A, a rotenoid with a new arrangement of the D-ring from the fruits of Millettia caerulea. | 2014 | Org. Lett. | pmid:24552419 |
| Imbeault E et al. | Nlrx1 regulates neuronal cell death. | 2014 | Mol Brain | pmid:25540124 |
| Corona JC et al. | PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. | 2014 | Exp. Neurol. | pmid:24374061 |
| Shi YL et al. | Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-X(L)/p53-mediated amplification mechanisms. | 2014 | Cell Death Dis | pmid:25522273 |
| Pal R et al. | Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells. | 2014 | FEBS Lett. | pmid:24374334 |
| Tang G et al. | Comparison of several supervised pattern recognition techniques for detecting additive methamidophos in rotenone preparation by near-infrared spectroscopy. | 2014 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:24368288 |
| Parmigiani A et al. | Sestrins inhibit mTORC1 kinase activation through the GATOR complex. | 2014 | Cell Rep | pmid:25457612 |
| Gruber J et al. | Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production. | 2014 | Bioorg. Med. Chem. | pmid:24393721 |
| Upegui Y et al. | Preparation of rotenone derivatives and in vitro analysis of their antimalarial, antileishmanial and selective cytotoxic activities. | 2014 | Molecules | pmid:25412039 |
| Deng Y and Lu J | [Role of rotenone in mitochondrial oxidative damage and the underlying mechanisms]. | 2014 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:25355263 |
| Agarwal B et al. | Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes. | 2014 | Biochim. Biophys. Acta | pmid:24355434 |
| Shang HS et al. | Deguelin inhibits the migration and invasion of U-2 OS human osteosarcoma cells via the inhibition of matrix metalloproteinase-2/-9 in vitro. | 2014 | Molecules | pmid:25322282 |
| Knaryan VH et al. | SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP(+) and rotenone. | 2014 | J. Neurochem. | pmid:24341912 |
| Gong LL et al. | Protective effects of Akebia saponin D against rotenone-induced hepatic mitochondria dysfunction. | 2014 | J. Pharmacol. Sci. | pmid:25319614 |
| Wu MM et al. | Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway. | 2014 | J Asian Nat Prod Res | pmid:24382325 |
| Bird MJ et al. | Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse. | 2014 | Biosci. Rep. | pmid:25312000 |
| Zhou Y et al. | Effect of two formulations on the decline curves and residue levels of rotenone in cabbage and soil under field conditions. | 2014 | Ecotoxicol. Environ. Saf. | pmid:24632119 |
| Wang H et al. | Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models. | 2014 | PLoS ONE | pmid:25303312 |
| Lin TK et al. | Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy. | 2014 | Int J Mol Sci | pmid:24451142 |
| Wang HS et al. | In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila. | 2014 | Mol Brain | pmid:25288323 |
| Rao DK et al. | A combination of curcumin with either gramicidin or ouabain selectively kills cells that express the multidrug resistance-linked ABCG2 transporter. | 2014 | J. Biol. Chem. | pmid:25253691 |
| Sanders LH et al. | Mitochondrial DNA damage as a peripheral biomarker for mitochondrial toxin exposure in rats. | 2014 | Toxicol. Sci. | pmid:25237061 |
| Basukriadi A and Wilkins RM | Oviposition deterrent activities of Pachyrhizus erosus seed extract and other natural products on Plutella xylostella (Lepidoptera: Plutellidae). | 2014 | J. Insect Sci. | pmid:25525107 |
| Murakami S et al. | Neuroprotective effects of metallothionein against rotenone-induced myenteric neurodegeneration in parkinsonian mice. | 2014 | Neurotox Res | pmid:24923464 |
| Xiao F et al. | Role of mitochondrial electron transport chain dysfunction in Cr(VI)-induced cytotoxicity in L-02 hepatocytes. | 2014 | Cell. Physiol. Biochem. | pmid:24732427 |
| Xu Y et al. | Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease. | 2014 | Cell. Signal. | pmid:24726895 |
| Jing X et al. | Rifampicin protects PC12 cells from rotenone-induced cytotoxicity by activating GRP78 via PERK-eIF2α-ATF4 pathway. | 2014 | PLoS ONE | pmid:24638036 |
| Jia F et al. | Unexpected improvements of spatial learning and memory abilities in chronic rotenone intoxicated mice. | 2014 | PLoS ONE | pmid:24618574 |
| Mor A et al. | Singlet oxygen signatures are detected independent of light or chloroplasts in response to multiple stresses. | 2014 | Plant Physiol. | pmid:24599491 |
| Li DL et al. | Glibenclamide decreases ATP-induced intracellular calcium transient elevation via inhibiting reactive oxygen species and mitochondrial activity in macrophages. | 2014 | PLoS ONE | pmid:24558474 |
| Prior S et al. | Mitochondrial respiratory function induces endogenous hypoxia. | 2014 | PLoS ONE | pmid:24586439 |
| Han G et al. | The mitochondrial complex I inhibitor rotenone induces endoplasmic reticulum stress and activation of GSK-3β in cultured rat retinal cells. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25082888 |
| Wallström SV et al. | Suppression of NDA-type alternative mitochondrial NAD(P)H dehydrogenases in arabidopsis thaliana modifies growth and metabolism, but not high light stimulation of mitochondrial electron transport. | 2014 | Plant Cell Physiol. | pmid:24486764 |
| Willis GL et al. | Parkinson's disease, lights and melanocytes: looking beyond the retina. | 2014 | Sci Rep | pmid:24473093 |
| Ju E et al. | Near-infrared light-triggered drug-delivery vehicle for mitochondria-targeted chemo-photothermal therapy. | 2014 | ACS Appl Mater Interfaces | pmid:24559457 |
| Gupta SP et al. | Does restraining nitric oxide biosynthesis rescue from toxins-induced parkinsonism and sporadic Parkinson's disease? | 2014 | Mol. Neurobiol. | pmid:23900742 |
| Fernando P et al. | Toxicological evaluation of a rotenone derivative in rodents for clinical myocardial perfusion imaging. | 2014 | Cardiovasc. Toxicol. | pmid:24395712 |
| Bienholz A et al. | Substrate modulation of fatty acid effects on energization and respiration of kidney proximal tubules during hypoxia/reoxygenation. | 2014 | PLoS ONE | pmid:24728405 |
| Currie HN et al. | An approach to investigate intracellular protein network responses. | 2014 | Chem. Res. Toxicol. | pmid:24359296 |
| Gao L et al. | Discovery of the neuroprotective effects of alvespimycin by computational prioritization of potential anti-Parkinson agents. | 2014 | FEBS J. | pmid:24304935 |
| Li B et al. | Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism. | 2014 | Neurosci. Lett. | pmid:24440618 |
| Dokleja L et al. | Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers. | 2014 | Neurosci. Lett. | pmid:25240592 |
| Balsera B et al. | Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: a new target for a privileged structure. | 2014 | Eur J Med Chem | pmid:25232969 |
| Noseda AC et al. | Putative role of monoamines in the antidepressant-like mechanism induced by striatal MT2 blockade. | 2014 | Behav. Brain Res. | pmid:25218873 |
| Varga SJ et al. | A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson's disease. | 2014 | Brain Res. | pmid:25130663 |
| Milowska K et al. | In vitro PAMAM, phosphorus and viologen-phosphorus dendrimers prevent rotenone-induced cell damage. | 2014 | Int J Pharm | pmid:25108046 |
| Jang W et al. | 1,25-Dyhydroxyvitamin D₃ attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25078626 |
| Hemion C et al. | Quality control of oxidatively damaged mitochondrial proteins is mediated by p97 and the proteasome. | 2014 | Free Radic. Biol. Med. | pmid:25062828 |
| Estrella-Parra EA et al. | Rotenone isolated from Pachyrhizus erosus displays cytotoxicity and genotoxicity in K562 cells. | 2014 | Nat. Prod. Res. | pmid:25055205 |
| Ye H et al. | Millettia pachycarpa exhibits anti-inflammatory activity through the suppression of LPS-induced NO/iNOS expression. | 2014 | Am. J. Chin. Med. | pmid:25004885 |
| Linghu L et al. | Mirabijalone E: a novel rotenoid from Mirabilis himalaica inhibited A549 cell growth in vitro and in vivo. | 2014 | J Ethnopharmacol | pmid:24882730 |
| Zhang XY et al. | Regulation of rotenone-induced microglial activation by 5-lipoxygenase and cysteinyl leukotriene receptor 1. | 2014 | Brain Res. | pmid:24858057 |
| Thakur P and Nehru B | Modulatory effects of sodium salicylate on the factors affecting protein aggregation during rotenone induced Parkinson's disease pathology. | 2014 | Neurochem. Int. | pmid:24852355 |
| Yan JQ et al. | Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway. | 2014 | Mol. Neurobiol. | pmid:24833599 |