9,10-DiHOME

9,10-dihome is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2500 references associated with 9,10-DiHOME in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 9,10-DiHOME

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 9,10-DiHOME

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Maxillary Diseases D008439 3 associated lipids
Goat Diseases D015511 6 associated lipids
Sheep Diseases D012757 10 associated lipids
Cattle Diseases D002418 24 associated lipids
Pulmonary Edema D011654 23 associated lipids
Leukemia D007938 74 associated lipids
Prosthesis-Related Infections D016459 7 associated lipids
Fusobacterium Infections D005674 3 associated lipids
Per page 10 20 50 | Total 29

PubChem Biomolecular Interactions and Pathways

All references with 9,10-DiHOME

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Per page 10 20 50 100 | Total 543
Authors Title Published Journal PubMed Link
Fagerberg SK et al. Inhibition of P2X Receptors Protects Human Monocytes against Damage by Leukotoxin from Aggregatibacter actinomycetemcomitans and α-Hemolysin from Escherichia coli. 2016 Infect. Immun. pmid:27528275
Webb JN et al. Inhibition of Bacterial Toxin Activity by the Nuclear Stain, DRAQ5â„¢. 2016 J. Membr. Biol. pmid:27039399
Velusamy SK et al. Profound Effects of Aggregatibacter actinomycetemcomitans Leukotoxin Mutation on Adherence Properties Are Clarified in in vitro Experiments. 2016 PLoS ONE pmid:26977924
Nocadello S et al. Crystal structures of the components of the Staphylococcus aureus leukotoxin ED. 2016 Acta Crystallogr D Struct Biol pmid:26894539
Balashova N et al. Aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in LFA-1 expressing immune cells. 2016 Mol Oral Microbiol pmid:26361372
Brown AC et al. Inhibition of LtxA toxicity by blocking cholesterol binding with peptides. 2016 Mol Oral Microbiol pmid:26352738
Smith KP et al. The conserved carboxyl domain of MorC, an inner membrane protein of Aggregatibacter actinomycetemcomitans, is essential for membrane function. 2016 Mol Oral Microbiol pmid:26205976
Kachlany SC Mechanisms of LtxA (Leukotoxin), a Potent New Anti-Inflammatory Agent for the Treatment of Alopecia Areata. 2015 J. Investig. Dermatol. Symp. Proc. pmid:26551939
Batra SA et al. Acylation Enhances, but Is Not Required for, the Cytotoxic Activity of Mannheimia haemolytica Leukotoxin in Bighorn Sheep. 2015 Infect. Immun. pmid:26216418
Turner CE and Sriskandan S Panton-Valentine leucocidin expression by Staphylococcus aureus exposed to common antibiotics. 2015 J. Infect. pmid:26028260
DiFranco KM et al. LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes. 2015 Leuk. Res. pmid:25850729
Ã…berg CH et al. Aggregatibacter actinomycetemcomitans: virulence of its leukotoxin and association with aggressive periodontitis. 2015 Virulence pmid:25494963
DuMont AL et al. Identification of a crucial residue required for Staphylococcus aureus LukAB cytotoxicity and receptor recognition. 2014 Infect. Immun. pmid:24379286
Subramaniam R et al. Bighorn sheep × domestic sheep hybrids survive Mannheimia haemolytica challenge in the absence of vaccination. 2014 Vet. Microbiol. pmid:24629771
Munksgaard PS et al. Sialic acid residues are essential for cell lysis mediated by leukotoxin from Aggregatibacter actinomycetemcomitans. 2014 Infect. Immun. pmid:24643533
Padmaja RJ and Halami PM Immunogenicity of Staphylococcus aureus LukM/F'-PV recombinant subunits: validation of diagnostic potential and evaluation of protective efficacy in vitro. 2014 Vet. Microbiol. pmid:24674742
Nieman DC et al. Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, immune dysfunction, and metabolite shifts in cyclists: a randomized, crossover trial. 2014 PLoS ONE pmid:25409020
Kaur M and Kachlany SC Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera) induces cofilin dephosphorylation and actin depolymerization during killing of malignant monocytes. 2014 Microbiology (Reading, Engl.) pmid:25169107
Höglund Åberg C et al. Leukotoxic activity of Aggregatibacter actinomycetemcomitans and periodontal attachment loss. 2014 PLoS ONE pmid:25093857
Silveira VR et al. Leukotoxicity of Aggregatibacter actinomycetemcomitans in generalized aggressive periodontitis in Brazilians and their family members. 2013 Sep-Oct J Appl Oral Sci pmid:24212989
Podolin PL et al. In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:23434473
Dietmann A et al. Effects of Aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells. 2013 Aug-Sep Microb. Pathog. pmid:23665198
Yoong P and Torres VJ The effects of Staphylococcus aureus leukotoxins on the host: cell lysis and beyond. 2013 Curr. Opin. Microbiol. pmid:23466211
Alonzo F and Torres VJ Bacterial survival amidst an immune onslaught: the contribution of the Staphylococcus aureus leukotoxins. 2013 PLoS Pathog. pmid:23436994
Childress C et al. Mlc is a transcriptional activator with a key role in integrating cyclic AMP receptor protein and integration host factor regulation of leukotoxin RNA synthesis in Aggregatibacter actinomycetemcomitans. 2013 J. Bacteriol. pmid:23475968
Brown AC et al. Aggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition/amino acid consensus site for membrane association. 2013 J. Biol. Chem. pmid:23792963
Aslam R et al. Activation of neutrophils by the two-component leukotoxin LukE/D from Staphylococcus aureus: proteomic analysis of the secretions. 2013 J. Proteome Res. pmid:23834436
Martinez-Martinez RE et al. Characterization of periodontal biofilm in Down syndrome patients: a comparative study. 2013 J Clin Pediatr Dent pmid:23855174
Laventie BJ et al. p-Sulfonato-calix[n]arenes inhibit staphylococcal bicomponent leukotoxins by supramolecular interactions. 2013 Biochem. J. pmid:23282185
Reinholdt J et al. Monodisperse and LPS-free Aggregatibacter actinomycetemcomitans leukotoxin: interactions with human β2 integrins and erythrocytes. 2013 Biochim. Biophys. Acta pmid:23234758
Alonzo F et al. CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. 2013 Nature pmid:23235831
Huang Y et al. Comparative genomic hybridization and transcriptome analysis with a pan-genome microarray reveal distinctions between JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans. 2013 Mol Oral Microbiol pmid:23194436
Simpson VR et al. Association of a lukM-positive clone of Staphylococcus aureus with fatal exudative dermatitis in red squirrels (Sciurus vulgaris). 2013 Vet. Microbiol. pmid:23182436
Stevens RH et al. Prophage induction in lysogenic Aggregatibacter actinomycetemcomitans cells co-cultured with human gingival fibroblasts, and its effect on leukotoxin release. 2013 Microb. Pathog. pmid:23022667
Dassanayake RP et al. Role of Bibersteinia trehalosi, respiratory syncytial virus, and parainfluenza-3 virus in bighorn sheep pneumonia. 2013 Vet. Microbiol. pmid:23025980
Pei Z et al. Phenotypic changes in nonfimbriated smooth strains of Aggregatibacter actinomycetemcomitans grown in low-humidity solid medium. 2013 Ultrastruct Pathol pmid:23573892
Miller MW et al. Phylogenetic and epidemiologic relationships among Pasteurellaceae from Colorado bighorn sheep herds. 2013 J. Wildl. Dis. pmid:23778616
Kumar A et al. Characterization of Fusobacterium necrophorum isolated from llama and alpaca. 2013 J. Vet. Diagn. Invest. pmid:23780933
Schreiner H et al. A comparison of Aggregatibacter actinomycetemcomitans (Aa) virulence traits in a rat model for periodontal disease. 2013 PLoS ONE pmid:23936002
DiFranco KM et al. Leukotoxin kills rodent WBC by targeting leukocyte function associated antigen 1. 2013 Comp. Med. pmid:24209968
Walters MJ et al. Membrane association and destabilization by Aggregatibacter actinomycetemcomitans leukotoxin requires changes in secondary structures. 2013 Mol Oral Microbiol pmid:23678967
Kwamin F et al. Interactions of extracts from selected chewing stick sources with Aggregatibacter actinomycetemcomitans. 2012 BMC Res Notes pmid:22537711
Jentsch H et al. Characterization of Aggregatibacter actinomycetemcomitans strains in periodontitis patients in Germany. 2012 Clin Oral Investig pmid:22246112
Ennibi OK et al. The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans in localized and generalized forms of aggressive periodontitis. 2012 Acta Odontol. Scand. pmid:22251014
Crouch CF et al. Cross protection of a Mannheimia haemolytica A1 Lkt-/Pasteurella multocida ΔhyaE bovine respiratory disease vaccine against experimental challenge with Mannheimia haemolytica A6 in calves. 2012 Vaccine pmid:22306859
Brown AC et al. Aggregatibacter actinomycetemcomitans leukotoxin cytotoxicity occurs through bilayer destabilization. 2012 Cell. Microbiol. pmid:22309134
Munksgaard PS et al. Leukotoxin from Aggregatibacter actinomycetemcomitans causes shrinkage and P2X receptor-dependent lysis of human erythrocytes. 2012 Cell. Microbiol. pmid:22906303
Conceição T et al. Staphylococcus aureus reservoirs and transmission routes in a Portuguese Neonatal Intensive Care Unit: a 30-month surveillance study. 2012 Microb. Drug Resist. pmid:22191392
DiFranco KM et al. Leukotoxin (Leukothera®) targets active leukocyte function antigen-1 (LFA-1) protein and triggers a lysosomal mediated cell death pathway. 2012 J. Biol. Chem. pmid:22467872
Bandhaya P et al. Aggregatibacter actinomycetemcomitans serotypes, the JP2 clone and cytolethal distending toxin genes in a Thai population. 2012 J. Clin. Periodontol. pmid:22471788
Ã…berg CH et al. Presence of JP2 and Non-JP2 Genotypes of Aggregatibacter actinomycetemcomitans and attachment loss in adolescents in Ghana. 2012 J. Periodontol. pmid:22376208
Tang G et al. Lipopolysaccharides mediate leukotoxin secretion in Aggregatibacter actinomycetemcomitans. 2012 Mol Oral Microbiol pmid:22394466
Aulik NA et al. Mannheimia haemolytica and its leukotoxin cause macrophage extracellular trap formation by bovine macrophages. 2012 Infect. Immun. pmid:22354029
Malachowa N et al. Staphylococcus aureus leukotoxin GH promotes inflammation. 2012 J. Infect. Dis. pmid:22872735
Singh K et al. Cytokine expression by pulmonary leukocytes from calves challenged with wild-type and leukotoxin-deficient Mannheimia haemolytica. 2012 Vet. J. pmid:21696986
Aulik NA et al. Mannheimia haemolytica leukotoxin binds cyclophilin D on bovine neutrophil mitochondria. 2011 Mar-Apr Microb. Pathog. pmid:21220005
Cortese VS et al. Serologic response to Mannheimia haemolytica in calves concurrently inoculated with inactivated or modified-live preparations of M. haemolytica and viral combination vaccines containing modified-live bovine herpesvirus type 1. 2011 Am. J. Vet. Res. pmid:22023134
Fong KP et al. Aggregatibacter actinomycetemcomitans leukotoxin is post-translationally modified by addition of either saturated or hydroxylated fatty acyl chains. 2011 Mol Oral Microbiol pmid:21729247
Claesson R et al. Detection of the highly leucotoxic JP2 clone of Aggregatibacter actinomycetemcomitans in members of a Caucasian family living in Sweden. 2011 J. Clin. Periodontol. pmid:21073494
Riegel P et al. Coagulase-positive Staphylococcus pseudintermedius from animals causing human endocarditis. 2011 Int. J. Med. Microbiol. pmid:21075051
Brage M et al. Humoral immune response to Aggregatibacter actinomycetemcomitans leukotoxin. 2011 J. Periodont. Res. pmid:21118415
Zhou H et al. Identification of a Fusobacterium necrophorum isolate that contains a new variant of the leukotoxin gene (lktA) from the hoof of a sheep with ovine footrot. 2011 Vet. Microbiol. pmid:21145671
Gupta A et al. In vitro synergism between LFA-1 targeting leukotoxin (Leukotheraâ„¢) and standard chemotherapeutic agents in leukemia cells. 2011 Leuk. Res. pmid:21664691
Stenderup K et al. Resolution of psoriasis by a leukocyte-targeting bacterial protein in a humanized mouse model. 2011 J. Invest. Dermatol. pmid:21654835
Furugen R et al. Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans. 2011 FEMS Microbiol. Lett. pmid:21658109
Pinheiro ET et al. Analysis of genotypic variation in genes associated with virulence in Aggregatibacter actinomycetemcomitans clinical isolates. 2011 J. Periodont. Res. pmid:21338357
Kelk P et al. Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin. 2011 Cell Death Dis pmid:21390060
Dassanayake RP et al. Co-expression of ovine LPS receptor CD14 with Mannheimia haemolytica leukotoxin receptor LFA-1 or Mac-1 does not enhance leukotoxin-induced cytotoxicity. 2011 Vet. Immunol. Immunopathol. pmid:21420740
Malachowa N et al. Global changes in Staphylococcus aureus gene expression in human blood. 2011 PLoS ONE pmid:21525981
Rylev M et al. Microbiological and immunological characteristics of young Moroccan patients with aggressive periodontitis with and without detectable Aggregatibacter actinomycetemcomitans JP2 infection. 2011 Mol Oral Microbiol pmid:21214871
Herndon CN et al. Comparison of passively transferred antibodies in bighorn and domestic lambs reveals one factor in differential susceptibility of these species to Mannheimia haemolytica-induced pneumonia. 2011 Clin. Vaccine Immunol. pmid:21613459
Feuerbacher LA et al. The cyclic-AMP receptor protein (CRP) regulon in Aggregatibacter actinomycetemcomitans includes leukotoxin. 2011 Microb. Pathog. pmid:21575705
Singh K et al. Cytotoxicity and cytokine production by bovine alveolar macrophages challenged with wild type and leukotoxin-deficient Mannheimia haemolytica. 2011 Vet. J. pmid:20542456
Singh K et al. Mannheimia haemolytica: bacterial-host interactions in bovine pneumonia. 2011 Vet. Pathol. pmid:20685916
Huber H et al. Genotypes, antibiotic resistance profiles and microarray-based characterization of methicillin-resistant Staphylococcus aureus strains isolated from livestock and veterinarians in Switzerland. 2011 Zoonoses Public Health pmid:20849461
Johansson A et al. Prevalence of systemic immunoreactivity to Aggregatibacter actinomycetemcomitans leukotoxin in relation to the incidence of myocardial infarction. 2011 BMC Infect. Dis. pmid:21362180
Elamin A et al. Prevalence of Aggregatibacter actinomycetemcomitans in Sudanese patients with aggressive periodontitis: a case-control study. 2011 J. Periodont. Res. pmid:21332472
Johansson A Aggregatibacter actinomycetemcomitans leukotoxin: a powerful tool with capacity to cause imbalance in the host inflammatory response. 2011 Toxins (Basel) pmid:22069708
Subramaniam R et al. Defective bacterial clearance is responsible for the enhanced lung pathology characteristic of Mannheimia haemolytica pneumonia in bighorn sheep. 2011 Vet. Microbiol. pmid:21742446
Kreitman RJ Synergistic targeting of leukemia with leukotoxin and chemotherapy. 2011 Leuk. Res. pmid:21764132
Hioe CE et al. HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA). 2011 PLoS ONE pmid:21850260
Laventie BJ et al. Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21930905
Aulik NA et al. Mannheimia haemolytica and its leukotoxin cause neutrophil extracellular trap formation by bovine neutrophils. 2010 Infect. Immun. pmid:20823211
Lawrence PK et al. A three-way comparative genomic analysis of Mannheimia haemolytica isolates. 2010 BMC Genomics pmid:20920355
Haubek D The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: evolutionary aspects, epidemiology and etiological role in aggressive periodontitis. 2010 APMIS Suppl. pmid:21214629
Takashima E et al. A quinol peroxidase inhibitor prevents secretion of a leukotoxin from Aggregatibacter actinomycetemcomitans. 2010 J. Periodont. Res. pmid:19602106
Kachlany SC Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapy. 2010 J. Dent. Res. pmid:20200418
Hedlin PD et al. Design and delivery of a cryptic PrP(C) epitope for induction of PrP(Sc)-specific antibody responses. 2010 Vaccine pmid:19925901
Zhou H et al. Fusobacterium necrophorum variants present on the hooves of lame pigs. 2010 Vet. Microbiol. pmid:19781870
Guo DH et al. An indirect ELISA for serodiagnosis of cattle footrot caused by Fusobacterium necrophorum. 2010 Anaerobe pmid:20304080
Ventura CL et al. Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics. 2010 PLoS ONE pmid:20661294
Shanthalingam S et al. Molecular cloning of CD18 of bison, deer and elk, and comparison with that of other ruminants and non-ruminants. 2010 Vet. Immunol. Immunopathol. pmid:20176404
Lawrence PK and Dassanayake RP Ovis aries CR4 is involved in Mannheimia haemolytica leukotoxin-induced cytotoxicity. 2010 Vet. Immunol. Immunopathol. pmid:20060597
Forman MS et al. Gangliosides block Aggregatibacter Actinomycetemcomitans leukotoxin (LtxA)-mediated hemolysis. 2010 Toxins (Basel) pmid:22069577
Vieira EM et al. Occurrence of Aggregatibacter actinomycetemcomitans in Brazilian Indians from Umutina Reservation, Mato Grosso, Brazil. 2009 Sep-Oct J Appl Oral Sci pmid:19936523
Zhou H et al. Identification of a leukotoxin sequence from Fusobacterium equinum. 2009 Vet. Microbiol. pmid:18783899
Müller HP Multilevel modeling of gingival bleeding on probing in young adult carriers of non-JP2-like strains of Aggregatibacter actinomycetemcomitans. 2009 Clin Oral Investig pmid:18704524
Fine DH et al. An improved cost-effective, reproducible method for evaluation of bone loss in a rodent model. 2009 J. Clin. Periodontol. pmid:19207885
Atapattu DN et al. Brief heat treatment increases cytotoxicity of Mannheimia haemolytica leukotoxin in an LFA-1 independent manner. 2009 Microb. Pathog. pmid:19185607
Shanthalingam S and Srikumaran S Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19706410

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