9,10-DiHOME

9,10-dihome is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2500 references associated with 9,10-DiHOME in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 9,10-DiHOME

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 9,10-DiHOME

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Maxillary Diseases D008439 3 associated lipids
Goat Diseases D015511 6 associated lipids
Sheep Diseases D012757 10 associated lipids
Cattle Diseases D002418 24 associated lipids
Pulmonary Edema D011654 23 associated lipids
Leukemia D007938 74 associated lipids
Prosthesis-Related Infections D016459 7 associated lipids
Fusobacterium Infections D005674 3 associated lipids
Per page 10 20 50 | Total 29

PubChem Biomolecular Interactions and Pathways

All references with 9,10-DiHOME

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Per page 10 20 50 100 | Total 543
Authors Title Published Journal PubMed Link
Wernicki A et al. Comparison of immunogenic properties of native and inactivated Mannheimia haemolytica Lkt in calves. 2008 Pol J Vet Sci pmid:18683535
Dassanayake RP et al. Bighorn sheep beta2-integrin LFA-1 serves as a receptor for Mannheimia haemolytica leukotoxin. 2008 J. Wildl. Dis. pmid:18689665
Müller HP Multilevel modeling of gingival bleeding on probing in young adult carriers of non-JP2-like strains of Aggregatibacter actinomycetemcomitans. 2009 Clin Oral Investig pmid:18704524
Atapattu DN et al. Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells. 2008 Infect. Immun. pmid:18765728
Fett T et al. Mannheimia haemolytica leukotoxin-induced cytolysis of caprine (Capra hircus) leukocytes is mediated by the CD18 subunit of beta2-integrins. 2008 Nov-Dec Microb. Pathog. pmid:18775487
Zhou H et al. Identification of a leukotoxin sequence from Fusobacterium equinum. 2009 Vet. Microbiol. pmid:18783899
Wang D et al. Molecular mimicry of Aggregatibacter actinomycetemcomitans with beta2 glycoprotein I. 2008 Oral Microbiol. Immunol. pmid:18793363
Czuprynski CJ et al. Activation of bovine neutrophils by partially purified Pasteurella haemolytica leukotoxin. 1991 Infect. Immun. pmid:1879935
Mangan DF et al. Lethal effects of Actinobacillus actinomycetemcomitans leukotoxin on human T lymphocytes. 1991 Infect. Immun. pmid:1879940
Akabane H [Synthesized leukotoxin: its biological activity and establishment of radioimmunoassay]. 1991 Hokkaido Igaku Zasshi pmid:1916629
Atapattu DN et al. Brief heat treatment increases cytotoxicity of Mannheimia haemolytica leukotoxin in an LFA-1 independent manner. 2009 Microb. Pathog. pmid:19185607
Fine DH et al. An improved cost-effective, reproducible method for evaluation of bone loss in a rodent model. 2009 J. Clin. Periodontol. pmid:19207885
Forestier C and Welch RA Identification of RTX toxin target cell specificity domains by use of hybrid genes. 1991 Infect. Immun. pmid:1937778
Ohta H et al. Nuclease-sensitive binding of an Actinobacillus actinomycetemcomitans leukotoxin to the bacterial cell surface. 1991 Infect. Immun. pmid:1937819
Taichman NS et al. Early changes in cytosolic calcium and membrane potential induced by Actinobacillus actinomycetemcomitans leukotoxin in susceptible and resistant target cells. 1991 J. Immunol. pmid:1940358
Sun DB et al. Identification of three immunodominant regions on leukotoxin protein of Fusobacterium necrophorum. 2009 Vet. Res. Commun. pmid:19449113
Balashova NV et al. Aggregatibacter actinomycetemcomitans LtxC is required for leukotoxin activity and initial interaction between toxin and host cells. 2009 Gene pmid:19450669
Larsen J et al. Evolution of the leukotoxin promoter in genus Mannheimia. 2009 BMC Evol. Biol. pmid:19480674
Majury AL and Shewen PE Preliminary investigation of the mechanism of inhibition of bovine lymphocyte proliferation by Pasteurella haemolytica A1 leukotoxin. 1991 Vet. Immunol. Immunopathol. pmid:1949583
Ayalew S et al. Intranasal vaccination of calves with Mannheimia haemolytica chimeric protein containing the major surface epitope of outer membrane lipoprotein PlpE, the neutralizing epitope of leukotoxin, and cholera toxin subunit B. 2009 Vet. Immunol. Immunopathol. pmid:19581005
Takashima E et al. A quinol peroxidase inhibitor prevents secretion of a leukotoxin from Aggregatibacter actinomycetemcomitans. 2010 J. Periodont. Res. pmid:19602106
Lally ET et al. Structure and function of the B and D genes of the Actinobacillus actinomycetemcomitans leukotoxin complex. 1991 Microb. Pathog. pmid:1961107
Lawson DA et al. Molecular analysis of periodontal pathogens. 1990 Arch. Oral Biol. pmid:1965114
Aberg CH et al. Presence of Aggregatibacter actinomycetemcomitans in young individuals: a 16-year clinical and microbiological follow-up study. 2009 J. Clin. Periodontol. pmid:19678862
Shanthalingam S and Srikumaran S Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19706410
Confer AW et al. Molecular aspects of virulence of Pasteurella haemolytica. 1990 Can. J. Vet. Res. pmid:1972901
Zhou H et al. Fusobacterium necrophorum variants present on the hooves of lame pigs. 2010 Vet. Microbiol. pmid:19781870
Kawamoto D et al. Genetic diversity and toxic activity of Aggregatibacter actinomycetemcomitans isolates. 2009 Oral Microbiol. Immunol. pmid:19832802
Conlon JA et al. Efficacy of recombinant leukotoxin in protection against pneumonic challenge with live Pasteurella haemolytica A1. 1991 Infect. Immun. pmid:1987075
Hedlin PD et al. Design and delivery of a cryptic PrP(C) epitope for induction of PrP(Sc)-specific antibody responses. 2010 Vaccine pmid:19925901
Vieira EM et al. Occurrence of Aggregatibacter actinomycetemcomitans in Brazilian Indians from Umutina Reservation, Mato Grosso, Brazil. 2009 Sep-Oct J Appl Oral Sci pmid:19936523
Kim TS et al. Serotypes of Aggregatibacter actinomycetemcomitans in patients with different ethnic backgrounds. 2009 J. Periodontol. pmid:19961385
Spitznagel J et al. Regulation of leukotoxin in leukotoxic and nonleukotoxic strains of Actinobacillus actinomycetemcomitans. 1991 Infect. Immun. pmid:2004819
Lawrence PK and Dassanayake RP Ovis aries CR4 is involved in Mannheimia haemolytica leukotoxin-induced cytotoxicity. 2010 Vet. Immunol. Immunopathol. pmid:20060597
Shanthalingam S et al. Molecular cloning of CD18 of bison, deer and elk, and comparison with that of other ruminants and non-ruminants. 2010 Vet. Immunol. Immunopathol. pmid:20176404
Whiteley LO et al. Morphological and morphometrical analysis of the acute response of the bovine alveolar wall to Pasteurella haemolytica A1-derived endotoxin and leucotoxin. 1991 J. Comp. Pathol. pmid:2019673
Kachlany SC Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapy. 2010 J. Dent. Res. pmid:20200418
Sutherland AD and Burrells C Interaction of red deer leucocytes with Pasteurella haemolytica leucotoxin. 1991 Vet. Rec. pmid:2024415
Guo DH et al. An indirect ELISA for serodiagnosis of cattle footrot caused by Fusobacterium necrophorum. 2010 Anaerobe pmid:20304080
Clinkenbeard KD and Upton ML Lysis of bovine platelets by Pasteurella haemolytica leukotoxin. 1991 Am. J. Vet. Res. pmid:2035922
Breider MA et al. Interaction of bovine neutrophils in Pasteurella haemolytica mediated damage to pulmonary endothelial cells. 1991 Vet. Immunol. Immunopathol. pmid:2038823
Singh K et al. Cytotoxicity and cytokine production by bovine alveolar macrophages challenged with wild type and leukotoxin-deficient Mannheimia haemolytica. 2011 Vet. J. pmid:20542456
Ventura CL et al. Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics. 2010 PLoS ONE pmid:20661294
Singh K et al. Mannheimia haemolytica: bacterial-host interactions in bovine pneumonia. 2011 Vet. Pathol. pmid:20685916
Styrt B et al. Time and temperature dependence of granulocyte damage by leucotoxic supernatants from Pasteurella haemolytica A1. 1990 J. Gen. Microbiol. pmid:2079620
Cruz WT et al. Deletion analysis resolves cell-binding and lytic domains of the Pasteurella leukotoxin. 1990 Mol. Microbiol. pmid:2082150
Aulik NA et al. Mannheimia haemolytica and its leukotoxin cause neutrophil extracellular trap formation by bovine neutrophils. 2010 Infect. Immun. pmid:20823211
Huber H et al. Genotypes, antibiotic resistance profiles and microarray-based characterization of methicillin-resistant Staphylococcus aureus strains isolated from livestock and veterinarians in Switzerland. 2011 Zoonoses Public Health pmid:20849461
Lawrence PK et al. A three-way comparative genomic analysis of Mannheimia haemolytica isolates. 2010 BMC Genomics pmid:20920355
Claesson R et al. Detection of the highly leucotoxic JP2 clone of Aggregatibacter actinomycetemcomitans in members of a Caucasian family living in Sweden. 2011 J. Clin. Periodontol. pmid:21073494
Riegel P et al. Coagulase-positive Staphylococcus pseudintermedius from animals causing human endocarditis. 2011 Int. J. Med. Microbiol. pmid:21075051
Brage M et al. Humoral immune response to Aggregatibacter actinomycetemcomitans leukotoxin. 2011 J. Periodont. Res. pmid:21118415
Zhou H et al. Identification of a Fusobacterium necrophorum isolate that contains a new variant of the leukotoxin gene (lktA) from the hoof of a sheep with ovine footrot. 2011 Vet. Microbiol. pmid:21145671
Haubek D The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: evolutionary aspects, epidemiology and etiological role in aggressive periodontitis. 2010 APMIS Suppl. pmid:21214629
Rylev M et al. Microbiological and immunological characteristics of young Moroccan patients with aggressive periodontitis with and without detectable Aggregatibacter actinomycetemcomitans JP2 infection. 2011 Mol Oral Microbiol pmid:21214871
Aulik NA et al. Mannheimia haemolytica leukotoxin binds cyclophilin D on bovine neutrophil mitochondria. 2011 Mar-Apr Microb. Pathog. pmid:21220005
Elamin A et al. Prevalence of Aggregatibacter actinomycetemcomitans in Sudanese patients with aggressive periodontitis: a case-control study. 2011 J. Periodont. Res. pmid:21332472
Pinheiro ET et al. Analysis of genotypic variation in genes associated with virulence in Aggregatibacter actinomycetemcomitans clinical isolates. 2011 J. Periodont. Res. pmid:21338357
Johansson A et al. Prevalence of systemic immunoreactivity to Aggregatibacter actinomycetemcomitans leukotoxin in relation to the incidence of myocardial infarction. 2011 BMC Infect. Dis. pmid:21362180
Kelk P et al. Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin. 2011 Cell Death Dis pmid:21390060
Dassanayake RP et al. Co-expression of ovine LPS receptor CD14 with Mannheimia haemolytica leukotoxin receptor LFA-1 or Mac-1 does not enhance leukotoxin-induced cytotoxicity. 2011 Vet. Immunol. Immunopathol. pmid:21420740
Malachowa N et al. Global changes in Staphylococcus aureus gene expression in human blood. 2011 PLoS ONE pmid:21525981
Feuerbacher LA et al. The cyclic-AMP receptor protein (CRP) regulon in Aggregatibacter actinomycetemcomitans includes leukotoxin. 2011 Microb. Pathog. pmid:21575705
Herndon CN et al. Comparison of passively transferred antibodies in bighorn and domestic lambs reveals one factor in differential susceptibility of these species to Mannheimia haemolytica-induced pneumonia. 2011 Clin. Vaccine Immunol. pmid:21613459
Stenderup K et al. Resolution of psoriasis by a leukocyte-targeting bacterial protein in a humanized mouse model. 2011 J. Invest. Dermatol. pmid:21654835
Furugen R et al. Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans. 2011 FEMS Microbiol. Lett. pmid:21658109
Gupta A et al. In vitro synergism between LFA-1 targeting leukotoxin (Leukotheraâ„¢) and standard chemotherapeutic agents in leukemia cells. 2011 Leuk. Res. pmid:21664691
Singh K et al. Cytokine expression by pulmonary leukocytes from calves challenged with wild-type and leukotoxin-deficient Mannheimia haemolytica. 2012 Vet. J. pmid:21696986
Fong KP et al. Aggregatibacter actinomycetemcomitans leukotoxin is post-translationally modified by addition of either saturated or hydroxylated fatty acyl chains. 2011 Mol Oral Microbiol pmid:21729247
Subramaniam R et al. Defective bacterial clearance is responsible for the enhanced lung pathology characteristic of Mannheimia haemolytica pneumonia in bighorn sheep. 2011 Vet. Microbiol. pmid:21742446
Kreitman RJ Synergistic targeting of leukemia with leukotoxin and chemotherapy. 2011 Leuk. Res. pmid:21764132
Hioe CE et al. HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA). 2011 PLoS ONE pmid:21850260
Highlander SK et al. Secretion and expression of the Pasteurella haemolytica Leukotoxin. 1990 J. Bacteriol. pmid:2185213
Whiteley LO et al. Immunohistochemical localization of Pasteurella haemolytica A1-derived endotoxin, leukotoxin, and capsular polysaccharide in experimental bovine Pasteurella pneumonia. 1990 Vet. Pathol. pmid:2191489
Laventie BJ et al. Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21930905
Lo RY Molecular characterization of cytotoxins produced by Haemophilus, Actinobacillus, Pasteurella. 1990 Can. J. Vet. Res. pmid:2193701
Cortese VS et al. Serologic response to Mannheimia haemolytica in calves concurrently inoculated with inactivated or modified-live preparations of M. haemolytica and viral combination vaccines containing modified-live bovine herpesvirus type 1. 2011 Am. J. Vet. Res. pmid:22023134
Forman MS et al. Gangliosides block Aggregatibacter Actinomycetemcomitans leukotoxin (LtxA)-mediated hemolysis. 2010 Toxins (Basel) pmid:22069577
Johansson A Aggregatibacter actinomycetemcomitans leukotoxin: a powerful tool with capacity to cause imbalance in the host inflammatory response. 2011 Toxins (Basel) pmid:22069708
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Jentsch H et al. Characterization of Aggregatibacter actinomycetemcomitans strains in periodontitis patients in Germany. 2012 Clin Oral Investig pmid:22246112
Ennibi OK et al. The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans in localized and generalized forms of aggressive periodontitis. 2012 Acta Odontol. Scand. pmid:22251014
Crouch CF et al. Cross protection of a Mannheimia haemolytica A1 Lkt-/Pasteurella multocida ΔhyaE bovine respiratory disease vaccine against experimental challenge with Mannheimia haemolytica A6 in calves. 2012 Vaccine pmid:22306859
Brown AC et al. Aggregatibacter actinomycetemcomitans leukotoxin cytotoxicity occurs through bilayer destabilization. 2012 Cell. Microbiol. pmid:22309134
Aulik NA et al. Mannheimia haemolytica and its leukotoxin cause macrophage extracellular trap formation by bovine macrophages. 2012 Infect. Immun. pmid:22354029
Ã…berg CH et al. Presence of JP2 and Non-JP2 Genotypes of Aggregatibacter actinomycetemcomitans and attachment loss in adolescents in Ghana. 2012 J. Periodontol. pmid:22376208
Tang G et al. Lipopolysaccharides mediate leukotoxin secretion in Aggregatibacter actinomycetemcomitans. 2012 Mol Oral Microbiol pmid:22394466
DiFranco KM et al. Leukotoxin (Leukothera®) targets active leukocyte function antigen-1 (LFA-1) protein and triggers a lysosomal mediated cell death pathway. 2012 J. Biol. Chem. pmid:22467872
Bandhaya P et al. Aggregatibacter actinomycetemcomitans serotypes, the JP2 clone and cytolethal distending toxin genes in a Thai population. 2012 J. Clin. Periodontol. pmid:22471788
Bowersock TL et al. Hematological changes in calves exposed to a mixture of lipopolysaccharide and crude leukotoxin of Pasteurella haemolytica. 1990 Can. J. Vet. Res. pmid:2249175
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Munksgaard PS et al. Leukotoxin from Aggregatibacter actinomycetemcomitans causes shrinkage and P2X receptor-dependent lysis of human erythrocytes. 2012 Cell. Microbiol. pmid:22906303
Stevens RH et al. Prophage induction in lysogenic Aggregatibacter actinomycetemcomitans cells co-cultured with human gingival fibroblasts, and its effect on leukotoxin release. 2013 Microb. Pathog. pmid:23022667
Dassanayake RP et al. Role of Bibersteinia trehalosi, respiratory syncytial virus, and parainfluenza-3 virus in bighorn sheep pneumonia. 2013 Vet. Microbiol. pmid:23025980
Styrt B et al. Granulocyte plasma membrane damage by leukotoxic supernatant from Pasteurella haemolytica A1 and protection by immune serum. 1990 Can. J. Vet. Res. pmid:2306664
Wilkie IW et al. The effect of Pasteurella haemolytica and the leukotoxin of Pasteurella haemolytica on bovine lung explants. 1990 Can. J. Vet. Res. pmid:2306666
Forestier C and Welch RA Nonreciprocal complementation of the hlyC and lktC genes of the Escherichia coli hemolysin and Pasteurella haemolytica leukotoxin determinants. 1990 Infect. Immun. pmid:2307519
Simpson VR et al. Association of a lukM-positive clone of Staphylococcus aureus with fatal exudative dermatitis in red squirrels (Sciurus vulgaris). 2013 Vet. Microbiol. pmid:23182436
Kraig E et al. Nucleotide sequence of the leukotoxin gene from Actinobacillus actinomycetemcomitans: homology to the alpha-hemolysin/leukotoxin gene family. 1990 Infect. Immun. pmid:2318535

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