Deguelin is a lipid of Polyketides (PK) class. Deguelin is associated with abnormalities such as Hypertensive disease, Parkinson Disease and athymia. The involved functions are known as inhibitors, Drug Interactions, ATP binding, Down-Regulation and Angiogenesis. Deguelin often locates in Endothelium, Vascular and Body tissue. The associated genes with Deguelin are MAP2K1 gene.
To understand associated biological information of Deguelin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Deguelin is suspected in Hypertensive disease, Parkinson Disease, athymia and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Deguelin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Retinopathy of Prematurity | D012178 | 9 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Retinal Neovascularization | D015861 | 4 associated lipids |
| Triple Negative Breast Neoplasms | D064726 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kang W et al. | Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. | 2018 | Int. J. Mol. Med. | pmid:29512685 |
| Hsiao YT et al. | Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-[Formula: see text]B Signaling Pathways. | 2018 | Am. J. Chin. Med. | pmid:29402127 |
| Wang A et al. | Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox). | 2018 | Mol. Cell. Biochem. | pmid:29030732 |
| Nukui M et al. | The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts. | 2018 | Viruses | pmid:30405048 |
| Chen J et al. | The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway. | 2018 | Cell. Physiol. Biochem. | pmid:30045011 |
| Yu X et al. | Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma. | 2017 | EBioMedicine | pmid:29129699 |
| Xu XD et al. | Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin. | 2017 | Int J Mol Sci | pmid:28208617 |
| Li W et al. | Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis. | 2017 | Oncotarget | pmid:28427230 |
| Russell DA et al. | Stereocontrolled semi-syntheses of deguelin and tephrosin. | 2017 | Org. Biomol. Chem. | pmid:28134391 |
| Lee TM et al. | Effect of lithium on ventricular remodelling in infarcted rats via the Akt/mTOR signalling pathways. | 2017 | Biosci. Rep. | pmid:28115595 |