| MeSH term | MeSH ID | Detail |
|---|---|---|
| Rabies | D011818 | 4 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
COUMESTROL
COUMESTROL is a lipid of Polyketides (PK) class. Coumestrol is associated with abnormalities such as Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule and Central precocious puberty. The involved functions are known as Process, antagonists, Accident due to exposure to weather conditions, physiological aspects and Cell Proliferation. Coumestrol often locates in Blood, Body tissue, Reproductive system, Membrane and Myometrial. The associated genes with COUMESTROL are GAPDH gene, PPID gene, pyridinoline, NODAL gene and Nitrogen fixation gene. The related lipids are enterodiol. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of COUMESTROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with COUMESTROL?
COUMESTROL is suspected in Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule, Central precocious puberty and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with COUMESTROL
PubChem Associated disorders and diseases
What pathways are associated with COUMESTROL
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with COUMESTROL?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with COUMESTROL?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with COUMESTROL?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with COUMESTROL?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with COUMESTROL?
Mouse Model
Mouse Model are used in the study 'Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer.' (Javid SH et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with COUMESTROL
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Takeuchi S et al. | Comparative study on the nuclear hormone receptor activity of various phytochemicals and their metabolites by reporter gene assays using Chinese hamster ovary cells. | 2009 | Biol. Pharm. Bull. | pmid:19182375 |
| Lapensee EW et al. | Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells. | 2009 | Environ. Health Perspect. | pmid:19270784 |
| Lammersfeld CA et al. | Prevalence, sources, and predictors of soy consumption in breast cancer. | 2009 | Nutr J | pmid:19159489 |
| Thorsteinson N et al. | In silico identification of anthropogenic chemicals as ligands of zebrafish sex hormone binding globulin. | 2009 | Toxicol. Appl. Pharmacol. | pmid:18725242 |
| Perez-Rivero JJ et al. | Phytoestrogen treatment induces testis alterations in dogs. Potential use in population control. | 2009 | Vet. Res. Commun. | pmid:18712487 |
| Guerrero-Bosagna CM et al. | Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice. | 2008 | BMC Physiol. | pmid:18793434 |
| Messina MJ and Wood CE | Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary. | 2008 | Nutr J | pmid:18522734 |
| Heindel JJ and vom Saal FS | Meeting report: batch-to-batch variability in estrogenic activity in commercial animal diets--importance and approaches for laboratory animal research. | 2008 | Environ. Health Perspect. | pmid:18335108 |
| Dip R et al. | Global gene expression profiles induced by phytoestrogens in human breast cancer cells. | 2008 | Endocr. Relat. Cancer | pmid:18310284 |
| Hong Y et al. | Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase. | 2008 | Biochem. Pharmacol. | pmid:18184606 |
| Kirihata Y et al. | Coumestrol decreases intestinal alkaline phosphatase activity in post-delivery mice but does not affect vitamin D receptor and calcium channels in post-delivery and neonatal mice. | 2008 | J. Reprod. Dev. | pmid:18160770 |
| Hedelin M et al. | Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women. | 2008 | J. Nutr. | pmid:18424605 |
| Yin T et al. | [Chemical constituents from Spatholobus sinensis]. | 2008 | Yao Xue Xue Bao | pmid:18357735 |
| Ekins S et al. | Computational discovery of novel low micromolar human pregnane X receptor antagonists. | 2008 | Mol. Pharmacol. | pmid:18579710 |
| Veiga DF et al. | Predicting transcriptional regulatory interactions with artificial neural networks applied to E. coli multidrug resistance efflux pumps. | 2008 | BMC Microbiol. | pmid:18565227 |
| Lightfoot JT | Sex hormones' regulation of rodent physical activity: a review. | 2008 | Int. J. Biol. Sci. | pmid:18449357 |
| Brown GR and Nemes C | The exploratory behaviour of rats in the hole-board apparatus: is head-dipping a valid measure of neophilia? | 2008 | Behav. Processes | pmid:18406075 |
| Kamphuis LG et al. | Two alternative recessive quantitative trait loci influence resistance to spring black stem and leaf spot in Medicago truncatula. | 2008 | BMC Plant Biol. | pmid:18366746 |
| Wang H et al. | The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. | 2008 | Mol. Endocrinol. | pmid:18096694 |
| Milnes MR et al. | Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species. | 2008 | Environ. Health Perspect. | pmid:18629309 |