| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Rabies | D011818 | 4 associated lipids |
COUMESTROL
COUMESTROL is a lipid of Polyketides (PK) class. Coumestrol is associated with abnormalities such as Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule and Central precocious puberty. The involved functions are known as Process, antagonists, Accident due to exposure to weather conditions, physiological aspects and Cell Proliferation. Coumestrol often locates in Blood, Body tissue, Reproductive system, Membrane and Myometrial. The associated genes with COUMESTROL are GAPDH gene, PPID gene, pyridinoline, NODAL gene and Nitrogen fixation gene. The related lipids are enterodiol. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of COUMESTROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with COUMESTROL?
COUMESTROL is suspected in Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule, Central precocious puberty and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with COUMESTROL
PubChem Associated disorders and diseases
What pathways are associated with COUMESTROL
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with COUMESTROL?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with COUMESTROL?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with COUMESTROL?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with COUMESTROL?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with COUMESTROL?
Mouse Model
Mouse Model are used in the study 'Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer.' (Javid SH et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with COUMESTROL
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tubbs C et al. | Activation of southern white rhinoceros (Ceratotherium simum simum) estrogen receptors by phytoestrogens: potential role in the reproductive failure of captive-born females? | 2012 | Endocrinology | pmid:22253418 |
| Walker VR et al. | Estrogen receptor-α mediates diethylstilbestrol-induced feminization of the seminal vesicle in male mice. | 2012 | Environ. Health Perspect. | pmid:22275727 |
| Zhang DW et al. | Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. | 2012 | J Nat Med | pmid:21898133 |
| Opalka M et al. | Mechanism of phytoestrogen action in Leydig cells of ganders (Anser anser domesticus): Interaction with estrogen receptors and steroidogenic enzymes. | 2012 | J Environ Sci Health A Tox Hazard Subst Environ Eng | pmid:22540659 |
| Jeon HY et al. | Effect of Aspergillus oryzae-challenged germination on soybean isoflavone content and antioxidant activity. | 2012 | J. Agric. Food Chem. | pmid:22409158 |
| Zhao E and Mu Q | Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. | 2011 Jan-Mar | Sci Pharm | pmid:21617769 |
| Carmichael SL et al. | Estimated dietary phytoestrogen intake and major food sources among women during the year before pregnancy. | 2011 | Nutr J | pmid:21978267 |
| Argenta DF et al. | LC analysis of coumestrol incorporated into topical lipid nanoemulsions. | 2011 | Pharmazie | pmid:22312696 |
| Kool J et al. | Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures. | 2011 | Anal Bioanal Chem | pmid:21107824 |
| Hoerger CC et al. | Quantification of five isoflavones and coumestrol in various solid agroenvironmental matrices using ¹³c₃-labeled internal standards. | 2011 | J. Agric. Food Chem. | pmid:21204535 |
| Kang HJ et al. | Antiproliferation and redifferentiation in thyroid cancer cell lines by polyphenol phytochemicals. | 2011 | J. Korean Med. Sci. | pmid:21738342 |
| Karieb S and Fox SW | Phytoestrogens directly inhibit TNF-α-induced bone resorption in RAW264.7 cells by suppressing c-fos-induced NFATc1 expression. | 2011 | J. Cell. Biochem. | pmid:21268069 |
| Kirihata Y et al. | Effects of coumestrol administration to pregnant and lactating mice on intestinal alkaline phosphatase activity. | 2011 | Phytother Res | pmid:21031635 |
| Liu MH et al. | The protective effects of coumestrol against amyloid-β peptide- and lipopolysaccharide-induced toxicity on mice astrocytes. | 2011 | Neurol. Res. | pmid:21708076 |
| Kim JE et al. | Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial. | 2011 | Nutr J | pmid:21936892 |
| Guan XY et al. | HPLC-DAD-MS(n) analysis and HPLC quantitation of chemical constituents in Xian-ling-gu-bao capsules. | 2011 | J Pharm Biomed Anal | pmid:21477963 |
| Khan SI et al. | Potential utility of natural products as regulators of breast cancer-associated aromatase promoters. | 2011 | Reprod. Biol. Endocrinol. | pmid:21693041 |
| Hedelin M et al. | Dietary phytoestrogens and the risk of ovarian cancer in the women's lifestyle and health cohort study. | 2011 | Cancer Epidemiol. Biomarkers Prev. | pmid:21098648 |
| Mlynarczuk J et al. | The adverse effect of phytoestrogens on the synthesis and secretion of ovarian oxytocin in cattle. | 2011 | Reprod. Domest. Anim. | pmid:19799752 |
| Bandera EV et al. | Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study. | 2011 | BMC Womens Health | pmid:21943063 |