| MeSH term | MeSH ID | Detail |
|---|---|---|
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Rabies | D011818 | 4 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
COUMESTROL
COUMESTROL is a lipid of Polyketides (PK) class. Coumestrol is associated with abnormalities such as Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule and Central precocious puberty. The involved functions are known as Process, antagonists, Accident due to exposure to weather conditions, physiological aspects and Cell Proliferation. Coumestrol often locates in Blood, Body tissue, Reproductive system, Membrane and Myometrial. The associated genes with COUMESTROL are GAPDH gene, PPID gene, pyridinoline, NODAL gene and Nitrogen fixation gene. The related lipids are enterodiol. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of COUMESTROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with COUMESTROL?
COUMESTROL is suspected in Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule, Central precocious puberty and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with COUMESTROL
PubChem Associated disorders and diseases
What pathways are associated with COUMESTROL
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with COUMESTROL?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with COUMESTROL?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with COUMESTROL?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with COUMESTROL?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with COUMESTROL?
Mouse Model
Mouse Model are used in the study 'Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer.' (Javid SH et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with COUMESTROL
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:6470421 | ||||
| pmid: | ||||
| Argenta DF et al. | Topical Delivery of Coumestrol from Lipid Nanoemulsions Thickened with Hydroxyethylcellulose for Antiherpes Treatment. | 2018 | AAPS PharmSciTech | pmid:28681331 |
| Nogowski L et al. | Effect of a mycooestrogen, zearalenone, and a phytooestrogen, coumestrol on the liver membrane insulin receptor of ovariectomized female rats. | 1993 | Acta Biochim. Pol. | pmid:8372543 |
| Kaminska B et al. | The effects of ACTH, phytoestrogens and estrogens on corticosterone secretion by gander adrenocortical cells in breeding and nonbreeding seasons. | 2008 | Acta. Biol. Hung. | pmid:18637557 |
| Reinen J et al. | Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization. | 2008 | Anal Bioanal Chem | pmid:18236033 |
| Kool J et al. | Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures. | 2011 | Anal Bioanal Chem | pmid:21107824 |
| Bovee TF et al. | Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities. | 2008 | Anal Bioanal Chem | pmid:18188547 |
| Mazur W et al. | Isotope dilution gas chromatographic-mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples. | 1996 | Anal. Biochem. | pmid:8789715 |
| Oosterkamp AJ et al. | Reversed-phase liquid chromatography coupled on-line to receptor affinity detection based on the human estrogen receptor. | 1996 | Anal. Chem. | pmid:8651492 |
| Zhang J et al. | Estrogen receptor-based fluorescence polarization assay for bisphenol analogues and molecular modeling study of their complexation mechanism. | 2018 | Anal. Chim. Acta | pmid:30143207 |
| Ueda M et al. | Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice. | 2012 | Anim. Sci. J. | pmid:22694330 |
| Wang M et al. | Effects of coumestrol administration to maternal mice during pregnancy and lactation on immunoblogulin A-secreting cells in mammary glands. | 2013 | Anim. Sci. J. | pmid:23590506 |
| Andersen C et al. | Effect of forage on the content of phyto-oestrogens in bovine milk. | 2009 | Animal | pmid:22444386 |
| Owen AJ et al. | Regulation of low-density lipoprotein receptor activity by estrogens and phytoestrogens in a HepG2 cell model. | 2004 | Ann. Nutr. Metab. | pmid:15331887 |
| Lee HI et al. | Effect of soybean coumestrol on Bradyrhizobium japonicum nodulation ability, biofilm formation, and transcriptional profile. | 2012 | Appl. Environ. Microbiol. | pmid:22307307 |
| Nogowski L et al. | Effect of phytooestrogen--coumestrol and oestrone on some aspects of carbohydrate metabolism in ovariectomized female rats. | 1992 | Arch Vet Pol | pmid:1339577 |
| Nogowski L | Effect of coumestrol on the insulin receptor in erythrocytes and liver membranes of female rabbits. | 1994 | Arch Vet Pol | pmid:8891181 |
| BICKOFF EM et al. | Estrogenic activity of coumestrol and related compounds. | 1960 | Arch. Biochem. Biophys. | pmid:13800504 |
| Jin SE et al. | Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots. | 2012 | Arch. Pharm. Res. | pmid:22644850 |