| MeSH term | MeSH ID | Detail |
|---|---|---|
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Rabies | D011818 | 4 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
COUMESTROL
COUMESTROL is a lipid of Polyketides (PK) class. Coumestrol is associated with abnormalities such as Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule and Central precocious puberty. The involved functions are known as Process, antagonists, Accident due to exposure to weather conditions, physiological aspects and Cell Proliferation. Coumestrol often locates in Blood, Body tissue, Reproductive system, Membrane and Myometrial. The associated genes with COUMESTROL are GAPDH gene, PPID gene, pyridinoline, NODAL gene and Nitrogen fixation gene. The related lipids are enterodiol. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of COUMESTROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with COUMESTROL?
COUMESTROL is suspected in Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule, Central precocious puberty and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with COUMESTROL
PubChem Associated disorders and diseases
What pathways are associated with COUMESTROL
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with COUMESTROL?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with COUMESTROL?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with COUMESTROL?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with COUMESTROL?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with COUMESTROL?
Mouse Model
Mouse Model are used in the study 'Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer.' (Javid SH et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with COUMESTROL
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu H et al. | Coumestrol inhibits carotid sinus baroreceptor activity by cAMP/PKA dependent nitric oxide release in anesthetized male rats. | 2015 | Biochem. Pharmacol. | pmid:25449602 |
| Castro CC et al. | Coumestrol treatment prevents Na+, K+ -ATPase inhibition and affords histological neuroprotection to male rats receiving cerebral global ischemia. | 2014 | Neurol. Res. | pmid:24512013 |
| Wang C et al. | High-throughput screening assays for estrogen receptor by using coumestrol, a natural fluorescence compound. | 2014 | J Biomol Screen | pmid:24019253 |
| de Lima PF et al. | Occurrence of isoflavonoids in Brazilian common bean germplasm (Phaseolus vulgaris L.). | 2014 | J. Agric. Food Chem. | pmid:25268033 |
| Robb EL and Stuart JA | Multiple phytoestrogens inhibit cell growth and confer cytoprotection by inducing manganese superoxide dismutase expression. | 2014 | Phytother Res | pmid:23526725 |
| Cho SY et al. | Coumestrol suppresses hypoxia inducible factor 1α by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells. | 2014 | Bioorg. Med. Chem. Lett. | pmid:24768446 |
| Seo DB et al. | Coumestrol induces mitochondrial biogenesis by activating Sirt1 in cultured skeletal muscle cells. | 2014 | J. Agric. Food Chem. | pmid:24712520 |
| Chandsawangbhuwana C and Baker ME | 3D models of human ERα and ERβ complexed with coumestrol. | 2014 | Steroids | pmid:24315835 |
| Mulligan AA et al. | Intakes and sources of isoflavones, lignans, enterolignans, coumestrol and soya-containing foods in the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk), from 7 d food diaries, using a newly updated database. | 2013 | Public Health Nutr | pmid:22939391 |
| Leuner O et al. | Distribution of isoflavones and coumestrol in neglected tropical and subtropical legumes. | 2013 | J. Sci. Food Agric. | pmid:22926873 |
| Gold EB et al. | Phytoestrogen and fiber intakes in relation to incident vasomotor symptoms: results from the Study of Women's Health Across the Nation. | 2013 | Menopause | pmid:23435028 |
| Liu S et al. | Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2. | 2013 | BMC Pharmacol Toxicol | pmid:23845105 |
| Ferreira-Dias G et al. | Coumestrol and its metabolite in mares' plasma after ingestion of phytoestrogen-rich plants: potent endocrine disruptors inducing infertility. | 2013 | Theriogenology | pmid:23845774 |
| Waetjen LE et al. | Relationship between dietary phytoestrogens and development of urinary incontinence in midlife women. | 2013 | Menopause | pmid:23096248 |
| Wang M et al. | Effects of coumestrol administration to maternal mice during pregnancy and lactation on immunoblogulin A-secreting cells in mammary glands. | 2013 | Anim. Sci. J. | pmid:23590506 |
| Lee YH et al. | Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells. | 2013 | Food Chem | pmid:23768371 |
| Kshirsagar UA et al. | Aerobic iron-based cross-dehydrogenative coupling enables efficient diversity-oriented synthesis of coumestrol-based selective estrogen receptor modulators. | 2013 | Chemistry | pmid:23946113 |
| Li Y et al. | Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. | 2013 | Environ. Health Perspect. | pmid:23384675 |
| MÅ‚ynarczuk J et al. | Adverse influence of coumestrol on secretory function of bovine luteal cells in the first trimester of pregnancy. | 2013 | Environ. Toxicol. | pmid:21656645 |
| Arispe SA et al. | Effect of phytoestrogens on basal and GnRH-induced gonadotropin secretion. | 2013 | J. Endocrinol. | pmid:24050980 |