| MeSH term | MeSH ID | Detail |
|---|---|---|
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Rabies | D011818 | 4 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
COUMESTROL
COUMESTROL is a lipid of Polyketides (PK) class. Coumestrol is associated with abnormalities such as Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule and Central precocious puberty. The involved functions are known as Process, antagonists, Accident due to exposure to weather conditions, physiological aspects and Cell Proliferation. Coumestrol often locates in Blood, Body tissue, Reproductive system, Membrane and Myometrial. The associated genes with COUMESTROL are GAPDH gene, PPID gene, pyridinoline, NODAL gene and Nitrogen fixation gene. The related lipids are enterodiol. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of COUMESTROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with COUMESTROL?
COUMESTROL is suspected in Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule, Central precocious puberty and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with COUMESTROL
PubChem Associated disorders and diseases
What pathways are associated with COUMESTROL
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with COUMESTROL?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with COUMESTROL?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with COUMESTROL?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with COUMESTROL?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with COUMESTROL?
Mouse Model
Mouse Model are used in the study 'Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer.' (Javid SH et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with COUMESTROL
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mueller SO et al. | Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. | 2004 | Toxicol. Sci. | pmid:15084758 |
| Magee PJ et al. | Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro. | 2004 | Cancer Lett. | pmid:15105043 |
| Wang Y et al. | Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes. | 2004 | Biol. Reprod. | pmid:15229138 |
| Walf AA et al. | Antidepressant effects of ERbeta-selective estrogen receptor modulators in the forced swim test. | 2004 | Pharmacol. Biochem. Behav. | pmid:15251261 |
| Bovee TF et al. | Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15276617 |
| Ikeda K et al. | Estrogen and phytoestrogen regulate the mRNA expression of adrenomedullin and adrenomedullin receptor components in the rat uterus. | 2004 | Mol. Cell. Endocrinol. | pmid:15279908 |
| Cotter AA and Cashman KD | The effect of two dietary and a synthetic phytoestrogen on transepithelial calcium transport in human intestinal-like Caco-2 cells. | 2005 | Eur J Nutr | pmid:15309423 |
| Lozovaya VV et al. | Isoflavonoid accumulation in soybean hairy roots upon treatment with Fusarium solani. | 2004 Jul-Aug | Plant Physiol. Biochem. | pmid:15331097 |
| Owen AJ et al. | Regulation of low-density lipoprotein receptor activity by estrogens and phytoestrogens in a HepG2 cell model. | 2004 | Ann. Nutr. Metab. | pmid:15331887 |
| Kanno S et al. | Effects of the phytoestrogen coumestrol on RANK-ligand-induced differentiation of osteoclasts. | 2004 | Toxicology | pmid:15363596 |
| Odum J et al. | Cumulative dietary energy intake determines the onset of puberty in female rats. | 2004 | Environ. Health Perspect. | pmid:15531430 |
| Bulayeva NN and Watson CS | Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways. | 2004 | Environ. Health Perspect. | pmid:15531431 |
| Naciff JM et al. | Impact of the phytoestrogen content of laboratory animal feed on the gene expression profile of the reproductive system in the immature female rat. | 2004 | Environ. Health Perspect. | pmid:15531437 |
| Matsumoto T et al. | Survey of estrogenic activity in fish feed by yeast estrogen-screen assay. | 2004 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:15556077 |
| Schoenroth LJ et al. | The effect of the phytoestrogen coumestrol on the NZB/W F1 murine model of systemic lupus. | 2004 | J. Autoimmun. | pmid:15571926 |
| Javid SH et al. | Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer. | 2005 | Carcinogenesis | pmid:15579483 |
| Kouki T et al. | Suppressive effect of neonatal treatment with a phytoestrogen, coumestrol, on lordosis and estrous cycle in female rats. | 2005 | Brain Res. Bull. | pmid:15607833 |
| Adlercreutz H et al. | An isotope dilution gas chromatographic-mass spectrometric method for the simultaneous assay of estrogens and phytoestrogens in urine. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15698545 |
| Pillon A et al. | Binding of estrogenic compounds to recombinant estrogen receptor-alpha: application to environmental analysis. | 2005 | Environ. Health Perspect. | pmid:15743715 |
| Cottiglia F et al. | New cytotoxic prenylated isoflavonoids from Bituminaria morisiana. | 2005 | Planta Med. | pmid:15770547 |