MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
Ovarian Diseases | D010049 | 5 associated lipids |
Rabies | D011818 | 4 associated lipids |
Endometrial Neoplasms | D016889 | 30 associated lipids |
COUMESTROL is a lipid of Polyketides (PK) class. Coumestrol is associated with abnormalities such as Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule and Central precocious puberty. The involved functions are known as Process, antagonists, Accident due to exposure to weather conditions, physiological aspects and Cell Proliferation. Coumestrol often locates in Blood, Body tissue, Reproductive system, Membrane and Myometrial. The associated genes with COUMESTROL are GAPDH gene, PPID gene, pyridinoline, NODAL gene and Nitrogen fixation gene. The related lipids are enterodiol. The related experimental models are Mouse Model.
To understand associated biological information of COUMESTROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
COUMESTROL is suspected in Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule, Central precocious puberty and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with COUMESTROL
MeSH term | MeSH ID | Detail |
---|---|---|
Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
Ovarian Diseases | D010049 | 5 associated lipids |
Rabies | D011818 | 4 associated lipids |
Endometrial Neoplasms | D016889 | 30 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer.' (Javid SH et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Baker VA et al. | Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays. | 1999 | Food Chem. Toxicol. | pmid:10069478 |
Patisaul HB et al. | Regulation of estrogen receptor beta mRNA in the brain: opposite effects of 17beta-estradiol and the phytoestrogen, coumestrol. | 1999 | Brain Res. Mol. Brain Res. | pmid:10101243 |
Dopp E et al. | Modulation of the intracellular calcium level in mammalian cells caused by 17beta-estradiol, different phytoestrogens and the anti-estrogen ICI 182780. | 1999 | J. Steroid Biochem. Mol. Biol. | pmid:10215038 |
Hunter DS et al. | Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogens in normal and neoplastic cells of the uterine myometrium. | 1999 | Cancer Res. | pmid:10397250 |
Ashby J et al. | Induction of hyperplasia and increased DNA content in the uterus of immature rats exposed to coumestrol. | 1999 | Environ. Health Perspect. | pmid:10504149 |
Yamada T et al. | Effect of grinding with hydroxypropyl cellulose on the dissolution and particle size of a poorly water-soluble drug. | 1999 | Chem. Pharm. Bull. | pmid:10517010 |
Yamada T et al. | Characterization of urinary metabolites of a new benzofuroquinoline derivative, 3,9-bis(N,N-dimethylcarbamoyloxy)-5 H-benzofuro[3,2-c]-quinoline-6-one (KCA-098), in dogs. | 1999 | Pharmazie | pmid:10522271 |
Dixon-Shanies D and Shaikh N | Growth inhibition of human breast cancer cells by herbs and phytoestrogens. | 1999 Nov-Dec | Oncol. Rep. | pmid:10523716 |
Sakabe K et al. | Inhibitory effect of natural and environmental estrogens on thymic hormone production in thymus epithelial cell culture. | 1999 | Int. J. Immunopharmacol. | pmid:10606005 |