| MeSH term | MeSH ID | Detail |
|---|---|---|
| Birth Weight | D001724 | 23 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
COUMESTROL
COUMESTROL is a lipid of Polyketides (PK) class. Coumestrol is associated with abnormalities such as Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule and Central precocious puberty. The involved functions are known as Process, antagonists, Accident due to exposure to weather conditions, physiological aspects and Cell Proliferation. Coumestrol often locates in Blood, Body tissue, Reproductive system, Membrane and Myometrial. The associated genes with COUMESTROL are GAPDH gene, PPID gene, pyridinoline, NODAL gene and Nitrogen fixation gene. The related lipids are enterodiol. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of COUMESTROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with COUMESTROL?
COUMESTROL is suspected in Infertility, Renal tubular disorder, Osteoporosis, Postmenopausal, Nodule, Central precocious puberty and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with COUMESTROL
PubChem Associated disorders and diseases
What pathways are associated with COUMESTROL
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with COUMESTROL?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with COUMESTROL?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with COUMESTROL?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with COUMESTROL?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with COUMESTROL?
Mouse Model
Mouse Model are used in the study 'Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer.' (Javid SH et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with COUMESTROL
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:6470421 | ||||
| pmid: | ||||
| McMurry CS and Dickerson RL | Effects of binary mixtures of six xenobiotics on hormone concentrations and morphometric endpoints of northern bobwhite quail (Colinus virginianus). | Chemosphere | pmid:11372873 | |
| BICKOFF EM et al. | Coumestrol, a new estrogen isolated from forage crops. | 1957 | Science | pmid:13486041 |
| BICKOFF EM et al. | Estrogenic activity of coumestrol and related compounds. | 1960 | Arch. Biochem. Biophys. | pmid:13800504 |
| NOTEBOOM WD and GORSKI J | ESTROGENIC EFFECTS OF GENISTEIN AND COUMESTROL DIACETATE. | 1963 | Endocrinology | pmid:14089631 |
| BICKOFF EM et al. | ISOLATION OF COUMESTROL AND OTHER PHENOLICS FROM ALFALFA BY COUNTERCURRENT DISTRIBUTION. | 1964 | J Pharm Sci | pmid:14255129 |
| CAYEN MN and COMMON RH | AN INVESTIGATION OF URINARY CONVERSION PRODUCTS OF COUMESTROL IN THE FOWL. | 1965 | Biochim. Biophys. Acta | pmid:14347952 |
| Knuckles BE et al. | Quantitative determination of coumestrol in dried alfalfa and alfalfa leaf protein concentrates containing chlorophyll. | 1975 | J Assoc Off Anal Chem | pmid:1158842 |
| Lindner HR | Occurrence of anabolic agents in plants and their importance. | 1976 | Environ Qual Saf Suppl | pmid:1066275 |
| Shutt DA | The effects of plant oestrogens on animal reproduction. | 1976 | Endeavour | pmid:62660 |
| Knuckles BE et al. | Coumestrol content of fractions obtained during wet processing of alfalfa. | 1976 Nov-Dec | J. Agric. Food Chem. | pmid:12201 |
| Shtereva R et al. | [Estrogenic activity of some lucerne varieties]. | 1977 | Vet Med Nauki | pmid:607555 |
| Mohsin M and Pal AK | Phyto-estrogen in relation to physiology of birds. Effect on the development of reproductive and endocrine organs of chicken. | 1977 | Indian Vet. J. | pmid:873599 |
| Lee YJ et al. | Coumestrol, NBD-norhexestrol, and dansyl-norhexestrol, fluorescent probes of estrogen-binding protiens. | 1977 | Biochemistry | pmid:880286 |
| Martin PM et al. | Phytoestrogen interaction with estrogen receptors in human breast cancer cells. | 1978 | Endocrinology | pmid:570914 |
| Verdeal K et al. | Affinity of phytoestrogens for estradiol-binding proteins and effect of coumestrol on growth of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. | 1980 | J. Natl. Cancer Inst. | pmid:6766510 |
| Mathieson RA and Kitts WD | Binding of phyto-oestrogen and oestradiol-17 beta by cytoplasmic receptors in the pituitary gland and hypothalamus of the ewe. | 1980 | J. Endocrinol. | pmid:7400718 |
| Pertschuk LP et al. | Histochemical analyses of steroid hormone receptors in breast and prostatic carcinoma. | 1980 | J. Histochem. Cytochem. | pmid:7440959 |
| Bartholomew RM and Ryan DS | Lack of mutagenicity of some phytoestrogens in the salmonella/mammalian microsome assay. | 1980 | Mutat. Res. | pmid:6449666 |