Wedelolactone is a lipid of Polyketides (PK) class. Wedelolactone is associated with abnormalities such as CLEFT LIP, CONGENITAL HEALED and Hepatitis. The involved functions are known as Signal Transduction, Cell Cycle Arrest, Apoptosis, luciferase activity and Metabolic Inhibition. Wedelolactone often locates in Protoplasm and Smooth muscle (tissue). The associated genes with Wedelolactone are CFB gene, Candidate Disease Gene, JAK2 gene, STAT2 gene and STAT3 gene.
To understand associated biological information of Wedelolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wedelolactone is suspected in CLEFT LIP, CONGENITAL HEALED, Hepatitis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Wedelolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sarveswaran S et al. | Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. | 2012 | Int. J. Oncol. | pmid:23076676 |
| Lee YJ et al. | Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. | 2012 | Eur J Med Chem | pmid:22926226 |
| Liu QM et al. | Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity. | 2012 | Food Chem. Toxicol. | pmid:22902823 |
| Benes P et al. | Redox state alters anti-cancer effects of wedelolactone. | 2012 | Environ. Mol. Mutagen. | pmid:22733624 |
| He M et al. | [Simultaneous determination of four compounds in Erzhiwan by HPLC]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22693900 |
| Lim S et al. | Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells. | 2012 | J. Cell. Biochem. | pmid:22678810 |
| Kato K et al. | AMPK limits IL-1-stimulated IL-6 synthesis in osteoblasts: involvement of IκB/NF-κB pathway. | 2012 | Cell. Signal. | pmid:22560875 |
| Deng H and Fang Y | Anti-inflammatory gallic Acid and wedelolactone are G protein-coupled receptor-35 agonists. | 2012 | Pharmacology | pmid:22488351 |
| Nanbara H et al. | Modulation of Wnt5a expression by periodontopathic bacteria. | 2012 | PLoS ONE | pmid:22485170 |
| Nichols DB et al. | Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives. | 2012 | Eur J Med Chem | pmid:22280819 |