Wedelolactone is a lipid of Polyketides (PK) class. Wedelolactone is associated with abnormalities such as CLEFT LIP, CONGENITAL HEALED and Hepatitis. The involved functions are known as Signal Transduction, Cell Cycle Arrest, Apoptosis, luciferase activity and Metabolic Inhibition. Wedelolactone often locates in Protoplasm and Smooth muscle (tissue). The associated genes with Wedelolactone are CFB gene, Candidate Disease Gene, JAK2 gene, STAT2 gene and STAT3 gene.
To understand associated biological information of Wedelolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wedelolactone is suspected in CLEFT LIP, CONGENITAL HEALED, Hepatitis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Wedelolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alopecia | D000505 | 14 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Agbottah E et al. | Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. | 2008 | AIDS Res Ther | pmid:18544167 |
| Luo Q et al. | Hepatoprotective Effect of Wedelolactone against Concanavalin A-Induced Liver Injury in Mice. | 2018 | Am. J. Chin. Med. | pmid:29737211 |
| Mohan S et al. | High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:18945937 |
| Huston WM et al. | Apoptosis is induced in Chlamydia trachomatis-infected HEp-2 cells by the addition of a combination innate immune activation compounds and the inhibitor wedelolactone. | 2011 | Am. J. Reprod. Immunol. | pmid:21463376 |
| Tseng CK et al. | An in vitro coupled transcription/translation reporter system for hepatitis C virus RNA-dependent RNA polymerase. | 2011 | Anal. Biochem. | pmid:21782784 |
| Patil AA et al. | Optimization of sample preparation variables for wedelolactone from Eclipta alba using Box-Behnken experimental design followed by HPLC identification. | 2013 | Ann Pharm Fr | pmid:23835023 |
| Lefas G and Chaconas G | High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete. | 2009 | Antimicrob. Agents Chemother. | pmid:19596868 |
| Roy RK et al. | Hair growth promoting activity of Eclipta alba in male albino rats. | 2008 | Arch. Dermatol. Res. | pmid:18478241 |
| Li X et al. | Action of fibroblast growth factor-2 on the intervertebral disc. | 2008 | Arthritis Res. Ther. | pmid:18435858 |