Wedelolactone is a lipid of Polyketides (PK) class. Wedelolactone is associated with abnormalities such as CLEFT LIP, CONGENITAL HEALED and Hepatitis. The involved functions are known as Signal Transduction, Cell Cycle Arrest, Apoptosis, luciferase activity and Metabolic Inhibition. Wedelolactone often locates in Protoplasm and Smooth muscle (tissue). The associated genes with Wedelolactone are CFB gene, Candidate Disease Gene, JAK2 gene, STAT2 gene and STAT3 gene.
To understand associated biological information of Wedelolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wedelolactone is suspected in CLEFT LIP, CONGENITAL HEALED, Hepatitis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Wedelolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alopecia | D000505 | 14 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Wagner H and Fessler B | [In vitro 5-lipoxygenase inhibition by Elipta alba extracts and the coumestan derivative wedelolactone]. | 1986 | Planta Med. | pmid:3797501 |
| Wong SM et al. | Wedelolactone and coumestan derivatives as new antihepatotoxic and antiphlogistic principles. | 1988 | Arzneimittelforschung | pmid:2458108 |
| Melo PA et al. | Inhibition of the myotoxic and hemorrhagic activities of crotalid venoms by Eclipta prostrata (Asteraceae) extracts and constituents. | 1994 | Toxicon | pmid:8079371 |
| Melo PA and Ownby CL | Ability of wedelolactone, heparin, and para-bromophenacyl bromide to antagonize the myotoxic effects of two crotaline venoms and their PLA2 myotoxins. | 1999 | Toxicon | pmid:9920492 |
| da Silva AJM PA et al. | Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11212092 |
| Lans C et al. | Medicinal and ethnoveterinary remedies of hunters in Trinidad. | 2001 | BMC Complement Altern Med | pmid:11737880 |
| Syed SD et al. | Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. | 2003 | Phytother Res | pmid:12722155 |
| Li CC et al. | Total synthesis of wedelolactone. | 2003 | J. Org. Chem. | pmid:14575477 |
| Jayathirtha MG and Mishra SH | Optimization of wedelolactone accumulation in shoot cultures of Eclipta alba. | 2003 | Indian J. Exp. Biol. | pmid:15320508 |