Wedelolactone is a lipid of Polyketides (PK) class. Wedelolactone is associated with abnormalities such as CLEFT LIP, CONGENITAL HEALED and Hepatitis. The involved functions are known as Signal Transduction, Cell Cycle Arrest, Apoptosis, luciferase activity and Metabolic Inhibition. Wedelolactone often locates in Protoplasm and Smooth muscle (tissue). The associated genes with Wedelolactone are CFB gene, Candidate Disease Gene, JAK2 gene, STAT2 gene and STAT3 gene.
To understand associated biological information of Wedelolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wedelolactone is suspected in CLEFT LIP, CONGENITAL HEALED, Hepatitis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Wedelolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alopecia | D000505 | 14 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Syed SD et al. | Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. | 2003 | Phytother Res | pmid:12722155 |
| Kobori M et al. | Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. | 2004 | Cell Death Differ. | pmid:14526390 |
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| Pôças ES et al. | Structure-activity relationship of wedelolactone analogues: structural requirements for inhibition of Na+, K+ -ATPase and binding to the central benzodiazepine receptor. | 2006 | Bioorg. Med. Chem. | pmid:16945543 |
| Markovic D et al. | The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium: putative role of interleukin-1beta. | 2007 | Endocrinology | pmid:17431005 |
| Tewtrakul S et al. | HIV-1 protease and HIV-1 integrase inhibitory substances from Eclipta prostrata. | 2007 | Phytother Res | pmid:17696192 |
| Lin FM et al. | Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells. | 2007 | Carcinogenesis | pmid:17942463 |
| Fedorov O et al. | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077363 |
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| Zimmermann TJ et al. | Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. | 2009 | Bioorg. Med. Chem. | pmid:19097799 |
| Diogo LC et al. | Inhibition of snake venoms and phospholipases A(2) by extracts from native and genetically modified Eclipta alba: isolation of active coumestans. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19320636 |
| Tanabe K et al. | Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells. | 2009 | Brain Res. | pmid:19362079 |
| Lefas G and Chaconas G | High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete. | 2009 | Antimicrob. Agents Chemother. | pmid:19596868 |
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| Tsai CH et al. | Herbal extract of Wedelia chinensis attenuates androgen receptor activity and orthotopic growth of prostate cancer in nude mice. | 2009 | Clin. Cancer Res. | pmid:19690196 |
| Rowe DL et al. | Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin. | 2009 | Breast Cancer (Auckl) | pmid:19809577 |
| Melo PA et al. | Ability of a synthetic coumestan to antagonize Bothrops snake venom activities. | 2010 Feb-Mar | Toxicon | pmid:19883675 |
| Tanabe K et al. | Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells. | 2010 | J Neuroinflammation | pmid:20205746 |
| Huang LH et al. | Lipid soluble smoke particles upregulate endothelin receptors in rat basilar artery. | 2010 | Toxicol. Lett. | pmid:20561571 |
| Yang JH et al. | [Regulation of NF-κB signal transduction pathway on cytokines in cultured nasal epithelium]. | 2010 | Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:21055061 |
| Chen QW et al. | Cigarette smoke extract promotes human vascular smooth muscle cell proliferation and survival through ERK1/2- and NF-κB-dependent pathways. | 2010 | ScientificWorldJournal | pmid:21057728 |
| Maalouf SW et al. | Inflammatory responses in epithelia: endotoxin-induced IL-6 secretion and iNOS/NO production are differentially regulated in mouse mammary epithelial cells. | 2010 | J Inflamm (Lond) | pmid:21118556 |
| Benes P et al. | Inhibition of topoisomerase IIα: novel function of wedelolactone. | 2011 | Cancer Lett. | pmid:21315506 |
| Meley D et al. | p53-mediated delayed NF-κB activity enhances etoposide-induced cell death in medulloblastoma. | 2010 | Cell Death Dis | pmid:21364648 |
| Patel MB et al. | Simultaneous estimation of andrographolide and wedelolactone in herbal formulations. | 2008 | Indian J Pharm Sci | pmid:21394279 |
| Huston WM et al. | Apoptosis is induced in Chlamydia trachomatis-infected HEp-2 cells by the addition of a combination innate immune activation compounds and the inhibitor wedelolactone. | 2011 | Am. J. Reprod. Immunol. | pmid:21463376 |
| Bharadwaj U et al. | Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. | 2011 | Carcinogenesis | pmid:21515913 |
| Rostelato-Ferreira S et al. | Heparin at low concentration acts as antivenom against Bothrops jararacussu venom and bothropstoxin-I neurotoxic and myotoxic actions. | 2010 | J Venom Res | pmid:21544183 |
| Patrikidou A et al. | Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells. | 2011 | Cancer Cell Int. | pmid:21569620 |
| Tanabe K et al. | Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells. | 2011 | J Neuroinflammation | pmid:21682888 |
| Sukumari-Ramesh S et al. | Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells. | 2011 | Int. J. Dev. Neurosci. | pmid:21704149 |
| Tseng CK et al. | An in vitro coupled transcription/translation reporter system for hepatitis C virus RNA-dependent RNA polymerase. | 2011 | Anal. Biochem. | pmid:21782784 |
| Khameneh HJ et al. | GM-CSF signalling boosts dramatically IL-1 production. | 2011 | PLoS ONE | pmid:21829580 |
| Bharadwaj U et al. | Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression. | 2011 | Mol. Cancer | pmid:21880146 |
| Zerbini LF et al. | Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy. | 2011 | PLoS ONE | pmid:21931671 |
| Prakash T et al. | Neuroprotective activity of Wedelia calendulacea on cerebral ischemia/reperfusion induced oxidative stress in rats. | 2011 | Indian J Pharmacol | pmid:22144773 |
| Li J et al. | Minimally modified LDL upregulates endothelin type B receptors in rat basilar artery. | 2012 | Microvasc. Res. | pmid:22198335 |
| Jie L et al. | Minimally modified LDL upregulates endothelin type B receptors in rat coronary artery via ERK1/2 MAPK and NF-κB pathways. | 2012 | Biochim. Biophys. Acta | pmid:22198514 |
| Upadhyay K et al. | Development and characterization of phyto-vesicles of wedelolactone for hepatoprotective activity. | 2012 | Drug Dev Ind Pharm | pmid:22204306 |
| Dos Santos JI et al. | Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLAâ‚‚ inhibition. | 2011 | PLoS ONE | pmid:22205953 |
| Zhang W et al. | Activation of nuclear factor-κB pathway is responsible for tumor necrosis factor-α-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro. | 2012 | Toxicol. Lett. | pmid:22207076 |
| Rance E et al. | Inhibition of IκB kinase by thalidomide increases hepatitis C virus RNA replication. | 2012 | J. Viral Hepat. | pmid:22239529 |
| Gao W et al. | Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus. | 2012 | PLoS ONE | pmid:22279582 |
| Nichols DB et al. | Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives. | 2012 | Eur J Med Chem | pmid:22280819 |
| Nanbara H et al. | Modulation of Wnt5a expression by periodontopathic bacteria. | 2012 | PLoS ONE | pmid:22485170 |
| Deng H and Fang Y | Anti-inflammatory gallic Acid and wedelolactone are G protein-coupled receptor-35 agonists. | 2012 | Pharmacology | pmid:22488351 |
| Kato K et al. | AMPK limits IL-1-stimulated IL-6 synthesis in osteoblasts: involvement of IκB/NF-κB pathway. | 2012 | Cell. Signal. | pmid:22560875 |
| Lim S et al. | Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells. | 2012 | J. Cell. Biochem. | pmid:22678810 |
| He M et al. | [Simultaneous determination of four compounds in Erzhiwan by HPLC]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22693900 |
| Benes P et al. | Redox state alters anti-cancer effects of wedelolactone. | 2012 | Environ. Mol. Mutagen. | pmid:22733624 |
| Liu QM et al. | Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity. | 2012 | Food Chem. Toxicol. | pmid:22902823 |
| Lee YJ et al. | Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. | 2012 | Eur J Med Chem | pmid:22926226 |
| Sarveswaran S et al. | Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. | 2012 | Int. J. Oncol. | pmid:23076676 |
| Benedetti G et al. | TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells. | 2013 | Biochem. Pharmacol. | pmid:23103562 |
| Golub AG et al. | Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors. | 2012 | Eur J Med Chem | pmid:23127989 |
| Lim WS et al. | Tumour necrosis factor alpha down-regulates the expression of peroxisome proliferator activated receptor alpha (PPARα) in human hepatocarcinoma HepG2 cells by activation of NF-κB pathway. | 2013 | Cytokine | pmid:23141142 |
| Chen Z et al. | Wedelolactone, a naturally occurring coumestan, enhances interferon-γ signaling through inhibiting STAT1 protein dephosphorylation. | 2013 | J. Biol. Chem. | pmid:23580655 |
| Xia Y et al. | Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2. | 2013 | Eur. J. Pharmacol. | pmid:23791612 |
| Patil AA et al. | Optimization of sample preparation variables for wedelolactone from Eclipta alba using Box-Behnken experimental design followed by HPLC identification. | 2013 | Ann Pharm Fr | pmid:23835023 |
| Buldak RJ et al. | Exogenous administration of visfatin affects cytokine secretion and increases oxidative stress in human malignant melanoma Me45 cells. | 2013 | J. Physiol. Pharmacol. | pmid:23959735 |
| Yuan F et al. | Wedelolactone inhibits LPS-induced pro-inflammation via NF-kappaB pathway in RAW 264.7 cells. | 2013 | J. Biomed. Sci. | pmid:24176090 |
| Wong SM et al. | Wedelolactone and coumestan derivatives as new antihepatotoxic and antiphlogistic principles. | 1988 | Arzneimittelforschung | pmid:2458108 |
| Xu D et al. | The wedelolactone derivative inhibits estrogen receptor-mediated breast, endometrial, and ovarian cancer cells growth. | 2014 | Biomed Res Int | pmid:25221777 |
| Liu YQ et al. | Inhibitory effect of Ecliptae herba extract and its component wedelolactone on pre-osteoclastic proliferation and differentiation. | 2014 | J Ethnopharmacol | pmid:25267578 |
| Hsieh CJ et al. | Wedelolactone inhibits breast cancer-induced osteoclastogenesis by decreasing Akt/mTOR signaling. | 2015 | Int. J. Oncol. | pmid:25421824 |
| Jayadeepa RM et al. | Review and research analysis of computational target methods using BioRuby and in silico screening of herbal lead compounds against pancreatic cancer using R programming. | 2014 | Curr. Drug Metab. | pmid:25431153 |
| Snyder NW et al. | 15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways. | 2015 | Chem. Biol. Interact. | pmid:25450232 |
| Lin WL et al. | Ethyl acetate extract of Wedelia chinensis inhibits tert-butyl hydroperoxide-induced damage in PC12 cells and D-galactose-induced neuronal cell loss in mice. | 2014 | BMC Complement Altern Med | pmid:25510435 |
| Huang W et al. | Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis. | 2015 | Toxicol. Sci. | pmid:25631491 |
| Nehybova T et al. | Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signalling. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25934092 |
| Chen H et al. | Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer. | 2015 | Oncotarget | pmid:25944687 |
| Zhao Y et al. | Wedelolactone Regulates Lipid Metabolism and Improves Hepatic Steatosis Partly by AMPK Activation and Up-Regulation of Expression of PPARα/LPL and LDLR. | 2015 | PLoS ONE | pmid:26168156 |
| Ding S et al. | Wedelolactone protects human bronchial epithelial cell injury against cigarette smoke extract-induced oxidant stress and inflammation responses through Nrf2 pathway. | 2015 | Int. Immunopharmacol. | pmid:26411738 |
| Fratantonio D et al. | Palmitate-induced endothelial dysfunction is attenuated by cyanidin-3-O-glucoside through modulation of Nrf2/Bach1 and NF-κB pathways. | 2015 | Toxicol. Lett. | pmid:26422990 |
| Alquézar C et al. | Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers. | 2016 | J Psychiatry Neurosci | pmid:26624524 |
| Berrak Ö et al. | The inhibition of PI3K and NFκB promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells. | 2016 | Biomed. Pharmacother. | pmid:26796279 |
| Lu Y et al. | Protective effect of wedelolactone against CCl4-induced acute liver injury in mice. | 2016 | Int. Immunopharmacol. | pmid:26921731 |
| Li L et al. | Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As). | 2016 | Phytomedicine | pmid:27002404 |
| Ali F et al. | Wedelolactone mitigates UVB induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of NFkB pathway. | 2016 | Eur. J. Pharmacol. | pmid:27164422 |
| Sarveswaran S et al. | Wedelolactone, an Anti-inflammatory Botanical, Interrupts c-Myc Oncogenic Signaling and Synergizes with Enzalutamide to Induce Apoptosis in Prostate Cancer Cells. | 2016 | Mol. Cancer Ther. | pmid:27474149 |
| Liu YQ et al. | Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway. | 2016 | Sci Rep | pmid:27558652 |
| Ferrari D et al. | Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation. | 2016 | Toxicol. Lett. | pmid:27793764 |