Wedelolactone is a lipid of Polyketides (PK) class. Wedelolactone is associated with abnormalities such as CLEFT LIP, CONGENITAL HEALED and Hepatitis. The involved functions are known as Signal Transduction, Cell Cycle Arrest, Apoptosis, luciferase activity and Metabolic Inhibition. Wedelolactone often locates in Protoplasm and Smooth muscle (tissue). The associated genes with Wedelolactone are CFB gene, Candidate Disease Gene, JAK2 gene, STAT2 gene and STAT3 gene.
To understand associated biological information of Wedelolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wedelolactone is suspected in CLEFT LIP, CONGENITAL HEALED, Hepatitis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Wedelolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alopecia | D000505 | 14 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| da Silva AJM PA et al. | Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11212092 |
| Lans C et al. | Medicinal and ethnoveterinary remedies of hunters in Trinidad. | 2001 | BMC Complement Altern Med | pmid:11737880 |
| Syed SD et al. | Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. | 2003 | Phytother Res | pmid:12722155 |
| Kobori M et al. | Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. | 2004 | Cell Death Differ. | pmid:14526390 |
| Li CC et al. | Total synthesis of wedelolactone. | 2003 | J. Org. Chem. | pmid:14575477 |
| Jayathirtha MG and Mishra SH | Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. | 2004 | Phytomedicine | pmid:15185851 |
| Jayathirtha MG and Mishra SH | Optimization of wedelolactone accumulation in shoot cultures of Eclipta alba. | 2003 | Indian J. Exp. Biol. | pmid:15320508 |
| Annie S et al. | Activity of Wedelia calendulacea Less. in post-menopausal osteoporosis. | 2006 | Phytomedicine | pmid:16360932 |
| Ruhland A et al. | Leishmania promastigotes activate PI3K/Akt signalling to confer host cell resistance to apoptosis. | 2007 | Cell. Microbiol. | pmid:16889626 |
| Pôças ES et al. | Structure-activity relationship of wedelolactone analogues: structural requirements for inhibition of Na+, K+ -ATPase and binding to the central benzodiazepine receptor. | 2006 | Bioorg. Med. Chem. | pmid:16945543 |
| Markovic D et al. | The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium: putative role of interleukin-1beta. | 2007 | Endocrinology | pmid:17431005 |
| Tewtrakul S et al. | HIV-1 protease and HIV-1 integrase inhibitory substances from Eclipta prostrata. | 2007 | Phytother Res | pmid:17696192 |
| Lin FM et al. | Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells. | 2007 | Carcinogenesis | pmid:17942463 |
| Fedorov O et al. | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077363 |
| Radhakrishnan P et al. | Cell type-specific activation of the cytomegalovirus promoter by dimethylsulfoxide and 5-aza-2'-deoxycytidine. | 2008 | Int. J. Biochem. Cell Biol. | pmid:18373939 |
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| Hammadi A et al. | Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activation. | 2008 | Nitric Oxide | pmid:18474259 |
| Roy RK et al. | Hair growth promoting activity of Eclipta alba in male albino rats. | 2008 | Arch. Dermatol. Res. | pmid:18478241 |
| Bremer E et al. | Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells. | 2008 | J. Mol. Med. | pmid:18504532 |
| Agbottah E et al. | Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. | 2008 | AIDS Res Ther | pmid:18544167 |
| Vender JR et al. | Inhibition of NFkappaB reduces cellular viability in GH3 pituitary adenoma cells. | 2008 | Neurosurgery | pmid:18580810 |
| Lim JH et al. | CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia. | 2008 | Cell. Microbiol. | pmid:18643924 |
| Xu CB et al. | Lipid-soluble smoke particles upregulate vascular smooth muscle ETB receptors via activation of mitogen-activating protein kinases and NF-kappaB pathways. | 2008 | Toxicol. Sci. | pmid:18718921 |
| Malara N et al. | Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. | 2008 | Cell Cycle | pmid:18931595 |
| Mohan S et al. | High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:18945937 |
| Rawal RK et al. | Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18947995 |
| Zimmermann TJ et al. | Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. | 2009 | Bioorg. Med. Chem. | pmid:19097799 |
| Diogo LC et al. | Inhibition of snake venoms and phospholipases A(2) by extracts from native and genetically modified Eclipta alba: isolation of active coumestans. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19320636 |
| Tanabe K et al. | Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells. | 2009 | Brain Res. | pmid:19362079 |
| Lefas G and Chaconas G | High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete. | 2009 | Antimicrob. Agents Chemother. | pmid:19596868 |
| Idris AI et al. | Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo. | 2009 | Mol. Cancer Ther. | pmid:19671767 |
| Tsai CH et al. | Herbal extract of Wedelia chinensis attenuates androgen receptor activity and orthotopic growth of prostate cancer in nude mice. | 2009 | Clin. Cancer Res. | pmid:19690196 |
| Rowe DL et al. | Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin. | 2009 | Breast Cancer (Auckl) | pmid:19809577 |
| Melo PA et al. | Ability of a synthetic coumestan to antagonize Bothrops snake venom activities. | 2010 Feb-Mar | Toxicon | pmid:19883675 |
| Tanabe K et al. | Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells. | 2010 | J Neuroinflammation | pmid:20205746 |
| Huang LH et al. | Lipid soluble smoke particles upregulate endothelin receptors in rat basilar artery. | 2010 | Toxicol. Lett. | pmid:20561571 |
| Yang JH et al. | [Regulation of NF-κB signal transduction pathway on cytokines in cultured nasal epithelium]. | 2010 | Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:21055061 |
| Chen QW et al. | Cigarette smoke extract promotes human vascular smooth muscle cell proliferation and survival through ERK1/2- and NF-κB-dependent pathways. | 2010 | ScientificWorldJournal | pmid:21057728 |
| Maalouf SW et al. | Inflammatory responses in epithelia: endotoxin-induced IL-6 secretion and iNOS/NO production are differentially regulated in mouse mammary epithelial cells. | 2010 | J Inflamm (Lond) | pmid:21118556 |
| Benes P et al. | Inhibition of topoisomerase IIα: novel function of wedelolactone. | 2011 | Cancer Lett. | pmid:21315506 |
| Meley D et al. | p53-mediated delayed NF-κB activity enhances etoposide-induced cell death in medulloblastoma. | 2010 | Cell Death Dis | pmid:21364648 |
| Patel MB et al. | Simultaneous estimation of andrographolide and wedelolactone in herbal formulations. | 2008 | Indian J Pharm Sci | pmid:21394279 |
| Huston WM et al. | Apoptosis is induced in Chlamydia trachomatis-infected HEp-2 cells by the addition of a combination innate immune activation compounds and the inhibitor wedelolactone. | 2011 | Am. J. Reprod. Immunol. | pmid:21463376 |
| Bharadwaj U et al. | Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. | 2011 | Carcinogenesis | pmid:21515913 |
| Rostelato-Ferreira S et al. | Heparin at low concentration acts as antivenom against Bothrops jararacussu venom and bothropstoxin-I neurotoxic and myotoxic actions. | 2010 | J Venom Res | pmid:21544183 |
| Patrikidou A et al. | Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells. | 2011 | Cancer Cell Int. | pmid:21569620 |
| Tanabe K et al. | Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells. | 2011 | J Neuroinflammation | pmid:21682888 |
| Sukumari-Ramesh S et al. | Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells. | 2011 | Int. J. Dev. Neurosci. | pmid:21704149 |
| Tseng CK et al. | An in vitro coupled transcription/translation reporter system for hepatitis C virus RNA-dependent RNA polymerase. | 2011 | Anal. Biochem. | pmid:21782784 |