Wedelolactone is a lipid of Polyketides (PK) class. Wedelolactone is associated with abnormalities such as CLEFT LIP, CONGENITAL HEALED and Hepatitis. The involved functions are known as Signal Transduction, Cell Cycle Arrest, Apoptosis, luciferase activity and Metabolic Inhibition. Wedelolactone often locates in Protoplasm and Smooth muscle (tissue). The associated genes with Wedelolactone are CFB gene, Candidate Disease Gene, JAK2 gene, STAT2 gene and STAT3 gene.
To understand associated biological information of Wedelolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wedelolactone is suspected in CLEFT LIP, CONGENITAL HEALED, Hepatitis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Wedelolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alopecia | D000505 | 14 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Agbottah E et al. | Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. | 2008 | AIDS Res Ther | pmid:18544167 |
| Vender JR et al. | Inhibition of NFkappaB reduces cellular viability in GH3 pituitary adenoma cells. | 2008 | Neurosurgery | pmid:18580810 |
| Lim JH et al. | CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia. | 2008 | Cell. Microbiol. | pmid:18643924 |
| Xu CB et al. | Lipid-soluble smoke particles upregulate vascular smooth muscle ETB receptors via activation of mitogen-activating protein kinases and NF-kappaB pathways. | 2008 | Toxicol. Sci. | pmid:18718921 |
| Malara N et al. | Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. | 2008 | Cell Cycle | pmid:18931595 |
| Mohan S et al. | High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:18945937 |
| Rawal RK et al. | Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18947995 |
| Zimmermann TJ et al. | Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. | 2009 | Bioorg. Med. Chem. | pmid:19097799 |
| Diogo LC et al. | Inhibition of snake venoms and phospholipases A(2) by extracts from native and genetically modified Eclipta alba: isolation of active coumestans. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19320636 |
| Tanabe K et al. | Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells. | 2009 | Brain Res. | pmid:19362079 |