Wedelolactone is a lipid of Polyketides (PK) class. Wedelolactone is associated with abnormalities such as CLEFT LIP, CONGENITAL HEALED and Hepatitis. The involved functions are known as Signal Transduction, Cell Cycle Arrest, Apoptosis, luciferase activity and Metabolic Inhibition. Wedelolactone often locates in Protoplasm and Smooth muscle (tissue). The associated genes with Wedelolactone are CFB gene, Candidate Disease Gene, JAK2 gene, STAT2 gene and STAT3 gene.
To understand associated biological information of Wedelolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wedelolactone is suspected in CLEFT LIP, CONGENITAL HEALED, Hepatitis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Wedelolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alopecia | D000505 | 14 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Benes P et al. | Inhibition of topoisomerase IIα: novel function of wedelolactone. | 2011 | Cancer Lett. | pmid:21315506 |
| Meley D et al. | p53-mediated delayed NF-κB activity enhances etoposide-induced cell death in medulloblastoma. | 2010 | Cell Death Dis | pmid:21364648 |
| Patel MB et al. | Simultaneous estimation of andrographolide and wedelolactone in herbal formulations. | 2008 | Indian J Pharm Sci | pmid:21394279 |
| Huston WM et al. | Apoptosis is induced in Chlamydia trachomatis-infected HEp-2 cells by the addition of a combination innate immune activation compounds and the inhibitor wedelolactone. | 2011 | Am. J. Reprod. Immunol. | pmid:21463376 |
| Bharadwaj U et al. | Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. | 2011 | Carcinogenesis | pmid:21515913 |
| Rostelato-Ferreira S et al. | Heparin at low concentration acts as antivenom against Bothrops jararacussu venom and bothropstoxin-I neurotoxic and myotoxic actions. | 2010 | J Venom Res | pmid:21544183 |
| Patrikidou A et al. | Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells. | 2011 | Cancer Cell Int. | pmid:21569620 |
| Tanabe K et al. | Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells. | 2011 | J Neuroinflammation | pmid:21682888 |
| Sukumari-Ramesh S et al. | Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells. | 2011 | Int. J. Dev. Neurosci. | pmid:21704149 |
| Tseng CK et al. | An in vitro coupled transcription/translation reporter system for hepatitis C virus RNA-dependent RNA polymerase. | 2011 | Anal. Biochem. | pmid:21782784 |